New York Giants wide receiver Sterling Shepard tore the ACL in his left knee in Monday's 23-16 loss to the Dallas Cowboys and will miss the remainder of the season.

Giants coach Brian Daboll confirmed the severity of the injury on Tuesday a day after New York's first loss of the season.

Shepard was hurt in a non-contact injury on the Giants' final play of the night, falling to the ground while running a route away from the play. He was then carted off the field.

This marks the fourth straight season Shepard has missed time due to an injury and the second year in a row his season has ended with a major one after he tore his Achilles in 2021.

He took a pay cut to stay with the Giants after appearing in just seven games last season but is not under contract for 2023, so Monday's game may have been his last with New York.

A second-round pick by the Giants in 2016, Shepard’s 362 career receptions rank eighth in franchise history.

The 29-year-old veteran leads New York with 154 receiving yards this year and has scored one touchdown while his 13 receptions are one fewer than Richie James Jr. for the most by a Giants receiver.

Kadarius Toney and Kenny Golladay, both of whom have been non-factors thus far with a combined four receptions for 22 yards, will likely be pressed into more duty with Shepard sidelined.

Myles Garrett was taken to hospital after the Cleveland Browns star was involved in a single-car accident.

The defensive end sustained injuries that were not life-threatening in the incident, which occurred around 3pm local time after Garrett had departed team training at the Browns' practice facility in Berea, Ohio in his Porsche.

It was reported by NFL.com that Garrett was responsive when officers arrived at the scene of the accident, while impairment is not suspected. The 26-year-old was travelling with one other passenger.

A statement released by Garrett's agent, Nicole Lynn, read: "Myles Garrett was involved in a one-car accident this afternoon and was transported to a local hospital to be evaluated. 

"While we are waiting to learn the extent of his injuries, he has been alert and responsive. 

"The Garrett family would like to thank the medical personnel that got Myles and his passenger out of the vehicle and safely transported to the hospital."

Garrett was the first overall pick in the 2017 draft and is a two-time first-team All-Pro.

He has three sacks through the opening three games of the 2022 NFL season, with the Browns (2-1) top of the AFC North having rebounded from a Week 2 loss to the New York Jets with a 29-17 beating of the Pittsburgh Steelers on Thursday.

CeeDee Lamb was motivated to "step up" for his game-winning catch in the Dallas Cowboys' victory over the New York Giants having been annoyed by a second-quarter drop.

The Cowboys' star receiver made a couple of first-half errors, one of which he looked certain to claim in his stride for a touchdown from an excellent deep ball from Cooper Rush, only for it to slip through his grasp.

But Lamb more than atoned by making a sensational one-handed grab for a touchdown with 8:30 to play.

It was the icing on the cake of an 89-yard drive, in which Rush – standing in again for the injured Dak Prescott – found Lamb on four occasions.

"It [the dropped pass] was a situation I had to deal with on my own. Obviously I’m the one that dropped the ball for the guys," Lamb said after the game. 

"So knowing that I had to make this up in the back end of the game, I just wanted to step up.

"I was willing to do anything to make up for a touchdown potentially that I left in the first quarter. It was tough. It was a tough one, but I'm happy we came out victorious."

Lamb finished the game with eight catches for 87 yards but conceded there were frustrations from his earlier mistakes.

"It was very frustrating. Honestly, just because I practice all week, all offseason just on focusing in on the ball, and I let that one slip away," he added.

"It was tough. Partially because, like I said, all the hard work I put in just for one play away, I let it slip."

Ezekiel Elliot's one-yard touchdown had earlier levelled the game, and Lamb – now the undisputed number one receiver in the team after Amari Cooper was traded to the Cleveland Browns – felt like his winning contribution was a breakthrough moment.

"Most definitely [it was a breakthrough moment]," Lamb said.

"I appreciate Kel [offensive coordinator Kellen Moore] for trusting in me, all the guys believing in my ability. 

"You know, it was a tough third quarter. I kept thinking about it. All the guys kept preaching to me, 'Let it go. Let it go. We still got more game left.' 

"And fourth quarter when I kept hearing my number being called I knew it was my opportunity again, so I had to step up.

"It's gonna have its ebbs and flows. It's all about being consistent. Staying positive. Everything's not going to go my way. And when it does, it's going to go big."

Stand-in quarterback Rush played in back-to-back NFL games for the first time in his career with Prescott still sidelined by a hand injury sustained in week one against the Tampa Bay Buccaneers.

For Rush, the focus is on the team and not any potential battle for a starting berth.

"I want to keep winning, as long as I'm in there let's keep winning," he said post-game.

"Trust each other both sides of the ball [and] we'll be alright."

Myles Garrett was taken to hospital after the Cleveland Browns star was involved in a single-car accident.

The defensive end sustained injuries that were not life-threatening in the incident, which occurred around 3pm local time after Garrett had departed team training at the Browns' practice facility in Berea, Ohio in his Porsche.

It was reported by NFL.com that Garrett was responsive when officers arrived at the scene of the accident, while impairment is not suspected. The 26-year-old was travelling with one other passenger.

A statement released by Garrett's agent, Nicole Lynn, read: "Myles Garrett was involved in a one-car accident this afternoon and was transported to a local hospital to be evaluated. 

"While we are waiting to learn the extent of his injuries, he has been alert and responsive. 

"The Garrett family would like to thank the medical personnel that got Myles and his passenger out of the vehicle and safely transported to the hospital."

Garrett was the first overall pick in the 2017 draft and is a two-time first-team All-Pro.

He has three sacks through the opening three games of the 2022 NFL season, with the Browns (2-1) top of the AFC North having rebounded from a Week 2 loss to the New York Jets with a 29-17 beating of the Pittsburgh Steelers on Thursday.

Dallas Cowboys backup quarterback Cooper Rush now boasts a 3-0 record as a starter after doing enough to help his side defeat the New York Giants 23-16 on Monday night.

Rush, who is starting in the place of injured franchise star Dak Prescott, upset the Cincinnati Bengals last week in the second start of his NFL career after also defeating the Minnesota Vikings in his 2021 debut.

Against the Giants, he had another clean game, completing 21 of 31 passes for 215 yards and a touchdown, finishing with no turnovers and no sacks allowed.

With the game tied at 13-13 in the fourth quarter – after earlier touchdowns from Giants running back Saquon Barkley and Cowboys running back Ezekiel Elliott – Rush completed a two-yard goal-line fade to top receiver CeeDee Lamb, which he pulled down with one hand in the back corner of the endzone.

In doing so, Rush became the first quarterback since the 1970 merger to lead game-winning drives in the fourth quarter or overtime in each of his first three starts, per ESPN.

While it was Elliott who got the rushing touchdown for the Cowboys, it was teammate Tony Pollard who was the more impressive runner on the day, finishing with 13 carries for 105 yards, while Elliott posted 15 carries for 73 yards.

Lamb was the best receiver from either team, catching eight of 12 targets for 87 yards and a touchdown, and it could have been an even bigger day if he did not drop a wide-open 50-yard pass in the first half.

Defensively, Cowboys edge rusher DeMarcus Lawrence was the star of the show with three sacks, while Pro Bowl cornerback Trevon Diggs snagged the game-sealing interception on the final drive.

Already hit hard by injuries during the early part of the season, the Los Angeles Chargers are now bracing to be without two more key players for an extended period.

NFL.com reports left tackle Rashawn Slater is expected to miss the remainder of the season after rupturing his biceps tendon during the Chargers' 38-10 loss to Jacksonville on Sunday.

Additionally, head coach Brandon Staley said standout edge rusher Joey Bosa is week-to-week with a "significant" groin injury the four-time Pro Bowler sustained in Sunday’s defeat.

The Chargers entered the game already without top wide receiver Keenan Allen (hamstring), center Corey Linsley (knee) and cornerback J.C. Jackson (ankle), while quarterback Justin Herbert played through a rib injury he incurred during Los Angeles' Week 2 loss to AFC West rivals the Kansas City Chiefs.

Slater, the 13th overall pick of the 2021 draft, is coming off an excellent rookie season in which he started 16 games and allowed just two sacks as Herbert’s blindside protector to earn a spot in the Pro Bowl.

"Rashawn is an All-Pro player, he is one of the best tackles in the game," Staley said. "It’s going to be a tough loss for us, but we’re trying to make sure, over the next couple of days, that we put good contingencies in place, that we put a group out there that can really play together, give us a chance to be the offence that we’re capable of being."

Either Storm Norton or Trey Pipkins is expected to take over for Slater. Norton started 15 games at right tackle last season but was beaten out by Pipkins for that spot in training camp.

Bosa has been an impact pass rusher since entering the NFL as the third overall selection of the 2016 draft. The seventh-year veteran led the Chargers with 10.5 sacks in 2021, the fourth time he’s reached double digits in that category for his career.

"It’s part of the NFL. It’s an attrition league and you have to be ready for it," said Staley, whose team fell to 1-2 with Sunday’s loss. "For it to happen to high-profile players like we have, it’s not uncommon in the NFL. What you have to do is weather that storm and stay together."

Staley added that Allen is expected to practice this week and has a chance to return for Sunday’s game at Houston. The five-time Pro Bowl receiver has missed the Chargers’ last two games but was listed as questionable for the Jacksonville contest.

Tua Tagovailoa is not in the league's concussion protocol ahead of the Miami Dolphins' game against the Cincinnati Bengals on Thursday.

It's still not a sure thing he will play, however.

Dolphins coach Mike McDaniel reiterated on Monday it was Tagovailoa's injured back that caused him to stumble to the ground in Sunday's 21-19 win over the Buffalo Bills and not a hit that caused his head to slam into the turf.

In addition to the injured back, McDaniel told reporters that Tagovailoa is also dealing with a sore ankle and his availability for Thursday is uncertain with the quick turnaround.

''It's my first time on a Thursday night game with Tua, so I don't assume anything,'' the first-year coach said in his press conference. ''But it wasn't out of the extreme norm of bumps and bruises after a game.''

Tagovailoa took an especially hard hit Sunday, as Bills linebacker Matt Milano pushed him to the ground, drawing a rougher the passer flag.

Tagovailoa's helmet slammed into the turf but he managed to get back to his feet quickly. However, he then shook his head and seemed to look woozy as he appeared to lose his balance as he stumbled back to the ground.

The 24-year-old went to the locker room to be assessed by the team's medical staff, with the team announcing a head injury that made him questionable to return.

He only missed three snaps, however, returning for the start of the third quarter – a decision that prompted the NFL and National Football League Players Association to conduct a joint review of how the decision was made to allow Tagovailoa to return.

McDaniel maintained, however, the proper protocols were followed and that Tagovailoa was cleared by the team and the independent neurologist.

"We wouldn't have moved forward in the direction we did had there been any sort of red flags, because you can't keep quarterbacks out of harm's way," McDaniel said. "So if he had a head issue, he wouldn't have been back out there."

Tagovailoa supported those claims, telling reporters after the game that it felt like he hyper-extended his back earlier in the contest and that his back locked up on him after the hit from Milano and that's why he stumbled.

The Dolphins did not practice on Monday but estimated Tagovailoa wouldn't have participated, listing him out with a back and ankle injury on their injury report.

"These Thursday night games, you get used to just doing the best you can. And we're trying to get information as fast as possible," McDaniel said. "We'll be working fluidly from that.

"But right now, especially in a hard-fought game like that, not just Tua, but there's a lot of players that we'll be adjusting to on the fly, seeing if they can turn it around and give a healthy outing on Thursday."

All the talk prior to the Week 3 contest between the Jacksonville Jaguars and the Los Angeles Chargers surrounded the health of Justin Herbert, the quarterback viewed as having ascended to the superstar level of Patrick Mahomes and Josh Allen.

By the end of an eye-opening afternoon at SoFi Stadium, the performance Herbert produced while battling fractured rib cartilage was completely overshadowed by that of a man crowned as a future great as early as high school as Trevor Lawrence's blistering start to his second season in the NFL reached new heights.

Freed from the shackles of working with the overmatched and underprepared Urban Meyer, Lawrence has quickly flourished in year two under the tutelage of former Philadelphia Eagles Super Bowl-winning head coach Doug Pederson.

And his evisceration of a seemingly improved Chargers defense in a 38-10 rout served as a compelling reminder that – for all the talk of Zach Wilson, Trey Lance, Justin Fields and Mac Jones – he is, and always was, the best quarterback from the much heralded 2021 draft class at the position.

Furthermore, even on a day when the Indianapolis Colts shocked the Kansas City Chiefs, it rubber-stamped the Jaguars' status as the most exciting and dangerous team in an AFC South division ripe for the taking.

It is the long-term picture that is more important for the Jaguars, though, and that is suddenly very bright after the clearest demonstration yet of the potential Lawrence has to take his place alongside the NFL's elite quarterbacks.

The raw numbers – a 71.8 per cent completion percentage, 262 passing yards, three touchdowns, zero interceptions and a passer rating of 115.5 – are impressive enough on their own.

Yet they do a poor job of illustrating how accurate, how composed and how devastatingly brilliant Lawrence was in helping deliver a result nobody outside of the Jacksonville facility would have thought possible three weeks ago.

There was little in a slightly underwhelming first quarter and a pair of red zone failures from the Jaguars to suggest Lawrence would outplay Herbert, and certainly not to the extent that he did.

But Lawrence finished the game delivering an accurate, well-thrown ball on 89.5 per cent of his 38 pass attempts, from which he threw just one pickable pass. Only four quarterbacks had a better well-thrown rate in Week 3 as of Sunday.

After twice coming up short from inside the 20, Lawrence then produced some of his best throws from inside the tight confines of the red zone, showing his incredible ability on the move for the Jaguars' first touchdown when he rolled to his right to evade the interior push of Otito Ogbonnia and produced a laser to find Zay Jones in the back of the endzone.

Zay Jones was the recipient of another superb deep throw over the middle on third down on the next drive, aided by Travis Etienne's blitz pickup of Derwin James, before Lawrence then hit Christian Kirk down the right sideline.

Lawrence showed his effectiveness rolling to both sides – a skill beyond many quarterbacks – when he looked to have finished that drive with a pinpoint throw to Evan Engram while moving to his left. Though that touchdown was overturned when a replay deemed Engram to have stepped out of bounds, the second half saw Lawrence punctuate the Jags' dominance in equally spectacular fashion.

James Robinson's 50-yard run put the Jaguars firmly in command and the running back duo of Robinson and Etienne allowed Jacksonville to play ball control before Lawrence hit Kirk on a high-velocity throw on a designed rollout for his second touchdown pass.

The final flourish was the defining moment of Lawrence's display. Having converted a third down by climbing the pocket under duress to deliver a dart to Marvin Jones Jr, Lawrence added the finishing touch on the Jags' final scoring drive by lofting a perfect throw over the head of Michael Davis and into the arms of the same receiver running a corner route to back of the endzone.

Marvin Jones deserves praise for a spectacular catch, but the stunning throw was yet another example of the ease with which Lawrence can dissect defenses with the physical gifts he has at his disposal.

Those attributes were wasted during Meyer's short stint in the NFL but Pederson has swiftly negated any damage done by the false start to Lawrence's career and seemingly put the man seen as the best quarterback prospect since Andrew Luck back on the path to stardom.

Through three weeks, Lawrence has a well-thrown rate of 85.8 per cent that is eighth in the NFL and he has a supporting cast that is quickly silencing critics of the Jags' team-building strategy.

All of Robinson's three touchdown runs have come on carries of 10 yards or more, giving him the most such scores in the NFL. Etienne, meanwhile, is eighth in yards after contact per attempt (min. 10 carries) among running backs with 2.73.

Kirk, after receiving a much-maligned $72million contract from the Jags, is justifying that deal by producing a big play on 45.8 per cent of his targets, the sixth-highest ratio among wide receivers with at least 10 targets, he and fellow free-agent acquisition Zay Jones combining for 37 catches, 22 of which have gone for a first down.

On defense, the Jaguars have registered 21 quarterback hits, a tally topped by just five teams, with the athleticism and versatility of their defensive front causing Herbert and other quarterbacks consistent problems. Edge rusher Josh Allen, a first-round pick in 2019, has registered a third of those hits and recorded two sacks and three tackles for loss while the Jaguars have also succeeded in quickly harnessing rookie first overall selection Travon Walker's freakish athleticism.

At the second level, another first-round rookie, Devin Lloyd, helped make Herbert's life miserable on Sunday with his skills in coverage. Lloyd had three pass breakups and an interception, providing help to a secondary that does not lack depth of talent. 

The Jags' strides on defense are reflected by them allowing opponents to score just six times in 33 drives, increasing Lawrence's room for error on the other side of the ball.

Yet such errors have been few from the former Clemson star and, while ups and downs are to be expected from a quarterback of his still limited experience at the highest level, Lawrence is playing with the confidence and assuredness of a man who may have already been through the worst of his pro career and survived unscathed.

Now with a head coach who understands how to make the most of his outstanding skill set and backed up by a talented if expensive supporting cast, Lawrence looks poised to grow into an even more dynamic and explosive playmaker at the game's most important position. For a franchise desperate to finally climb out of the doldrums, that development is priceless.

An MRI on Monday confirmed what the New England Patriots feared regarding Mac Jones' ankle.

Jones suffered a "pretty severe" high ankle sprain in Sunday’s 37-26 loss to the Baltimore Ravens, according to NFL Network Insider Tom Pelissero.

The team is hopeful the 24-year-old quarterback will be able to recover without needing surgery, and though they haven't given a timetable for a return or confirmed if a stint on injured reserve is necessary, it seems unlikely he'll be able to play on Sunday against the Green Bay Packers.

That means veteran Brian Hoyer would be in line to make his first start since Week 4 of the 2020 season, when he threw for just 130 yards with no touchdown passes and one interception in New England's 26-10 loss to the Kansas City Chiefs.

Jones was hurt on the Patriots' final offensive play on Sunday, an interception with 1:55 remaining. The 2021 first-round pick landed hard on the turf from a hit by Baltimore defensive lineman Calais Campbell, then hobbled to the sidelines while grabbing his ankle before being taken straight to the locker room.

Jones threw for 321 yards in Sunday's loss, but was intercepted three times, giving him five through the 1-2 Patriots' first three games.

The NFL's end-of-season All-Star game, the Pro Bowl, has been scrapped and replaced by The Pro Bowl Games, the league announced on Monday.

Set to take place the week before Super Bowl LVII, the Pro Bowl Games will pit the AFC and NFC against each other in a multi-day skills competition culminating in a flag football game on February 5 at Allegiant Stadium in Las Vegas.

"We've received invaluable feedback from players, teams and fans about reimagining the Pro Bowl, and as a result, we're thrilled to use The Pro Bowl Games as a platform to spotlight Flag football as an integral part of the sport's future while also introducing fun, new forms of competition and entertainment that will bring our players, their families and fans closer than ever before," said Peter O'Reilly, NFL Executive Vice President, Club Business and League Events.

"Building on the success of the 2022 Pro Bowl and 2022 Draft, as well as our strong partnership with the Las Vegas Convention and Visitors Authority (LVCVA) and Las Vegas Raiders, we look forward to bringing The 2023 Pro Bowl Games to the capital of world-class sports and entertainment."

The Pro Bowl has been a consistent feature of the NFL calendar since 1951.

Following the NFL-AFL merger in 1970, it has seen star players from the AFC and NFC face off, save for a three-year period between 2013 and 2015 when teams were drafted by legendary former players.

Yet the on-field product has received frequent criticism.

Since the 2009 season, the Pro Bowl has been held the week before the Super Bowl, firmly removing players from teams participating in the title game from the field, while many of the league's stars voted to feature in the Pro Bowl have regularly pulled out citing injury concerns.

The additional risk of injury in the exhibition led the game to become a disappointing spectacle, with players eschewing tackling and any significant contact to protect their bodies. With the changes, the league will now hope it has found a solution to a persistent problem.

The AFC won last year's game, prevailing 41-35.

Nathaniel Hackett hopes Russell Wilson's game-winning drive against the San Francisco 49ers will be the start of his success with the Denver Broncos.

Wilson piloted a struggling Denver offense through the first two games of the season, an underwhelming start to his Broncos career coming after they traded five draft picks, including two first-rounders, and three players to acquire him from the Seattle Seahawks.

Then handed a five-year, $245million extension by the Broncos, Wilson lost in Week 1 on an emotional return to Seattle, before the Denver offense was jeered and mocked by its own home fans in Week 2 in an unconvincing win over the Houston Texans.

Wilson and the Broncos struggled for most of their win over the 49ers against a ferocious San Francisco defense that held the quarterback to 184 yards passing and Denver to just 3.7 yards per play. 

But the 49ers' ineptitude on offense in Jimmy Garoppolo's first start since Trey Lance's season-ending injury saw San Francisco waste a host of opportunities to take command, the Niners going one for 10 on third down. 

And Wilson finally capitalised on their profligacy in the fourth quarter, showing some of his trademark elusiveness that some believed may be waning to lead a 12-play, 80-yard drive and give the Broncos a decisive 11-10 lead.

Garoppolo was intercepted on the subsequent drive, and a Jeff Wilson Jr. fumble then sealed the game for Denver.

"Russell has come to a new state, a new organisation, with 10 brand new guys in the huddle," Hackett told NBC Sports' Peter King for his Football Morning in America column.

"It's a completely new look, new team. He's jumped in here and tried to make it as familiar as he could. On that winning drive, he said, 'I'm comfortable, I'm gonna use my legs here, I've got to make this happen'. He did. Hopefully that's the start of it for him."

Hackett's game management came under severe scrutiny in the opening two weeks of his tenure as Denver head coach, his struggles in that regard encapsulated by the home crowd counting down the play clock in Week 2 after his offense had struggled to get the ball snapped in time on several plays.

Ahead of Week 3, Hackett brought in veteran assistant coach Jerry Rosburg to help with gameday decisions.

Asked if doing so felt embarrassing, Hackett said: "No. For me, I felt empowered that I was able to make a decision. Hey, let's fix it. I'm the leader of the team. Let’s do it.

"This was the first time, the past two games, that I felt I was hurting my team. Did I have enough info? I don't know. But I knew the setup wasn't right. I needed help to make the tough decision."

Lamar Jackson's sensational start to the 2022 season is "a natural next step", according to Baltimore Ravens coach John Harbaugh, who always believed the quarterback could be "everything he is".

The Ravens improved to 2-1 with a 37-26 win over the New England Patriots on Sunday, in which Jackson threw four touchdown passes and rushed for 107 yards and a further score.

The fifth-year QB became only the second player in NFL history with at least four TD passes, 100 rushing yards and a rushing TD in a game after the Philadelphia Eagles' Randall Cunningham – also against the Patriots – in Week 9 of the 1990 season.

But Jackson also had three TD passes and 100 rushing yards in Week 2 against the Miami Dolphins.

Only seven other QBs (including Cunningham) have previously enjoyed such a performance, and none of them have done so more than once. Jackson has achieved that feat in consecutive games and four times across his career.

Surely a contender again this year, Jackson was the MVP in 2019 when he led the league in passing TDs (36), as he does now (10).

The failure to agree a new Ravens contract in the offseason would likely have made Jackson more determined to bounce back from an injury-hit 2021, but Harbaugh has never doubted his star man.

"No one has to tell me about Lamar Jackson," the Baltimore coach said.

"I believe in him. I love him. I just believed him the first day we drafted him, the first day we talked about drafting him. I felt like he could be everything he is.

"I just think it's a natural next step in terms of like finding his rhythm during the week, what he's looking at, how he studies defenses, how he breaks defenses down.

"It's not a lightbulb thing; it's an evolution of studying the game that you see quarterbacks go through."

Jackson offered his own take on his development, adding: "I'd just say [it is down to] maturity, just because of my age, just knowing the game of football just basically inside out.

"You've just got to stay locked in. That's probably the thing, just being locked in no matter what's going on during the game."

Tom Brady acknowledges there have been problems with "execution" right throughout the Tampa Bay Buccaneers' offense this season.

The Bucs ranked second in both total touchdowns (63), yards (6,901) and points (511) in 2021, trailing only the Dallas Cowboys in each category.

But after losing 14-12 to the Green Bay Packers in Week 3 this year, Tampa Bay rank joint-27th in total TDs (four), 25th in yards (892) and joint-21st in points (51).

Never has Brady thrown fewer TD passes through his first three starts of a season (three), while only in four seasons has he had fewer passing yards at this stage (673).

"We've just got to do a better job," said Brady, who insisted a finger injury had "zero" impact on the Packers result.

"I wish it was one thing; we're not running as good as we're capable, the passing game hasn't been very good, our screen game. There are a lot of things."

He added: "Our job is to go out there and score points, so we're just not doing it. We're not going to score points if we don't execute well.

"They [the Packers] did a better job than us – good defense, good, physical defense, I give them a lot of credit.

"They forced us to make a lot of good plays, and we just didn't do a great job in execution."

Still, Brady is not panicking, saying: "We're 2-1. There's a lot of football left. We'll keep working at it.

"It doesn't get any easier next week, going up against the Chiefs, but no one feels sorry for us, nor should we. We've just got to go back to work."

The Jacksonville Jaguars believe they can be "something special" after Trevor Lawrence ended his wait for a first NFL road win in impressive fashion against the Los Angeles Chargers.

The Chargers are among the favourites in the AFC this season but were beaten 38-10 with Justin Herbert playing through injury at SoFi Stadium.

Lawrence outshone Herbert, throwing for 262 yards and three touchdowns on 28-of-39 passing.

After nine straight defeats on the road to start his career, Lawrence finally guided the Jaguars to victory; the last NFL quarterback to start his career with nine away road losses and then a win was Peyton Manning.

And this was a commanding win, too – the Jaguars' biggest on the road since the 2001 season (33-3 at the Minnesota Vikings in Week 15).

Jacksonville have not enjoyed a winning season since 2017 and had only four victories over the previous two campaigns combined.

But they are halfway to that number already in 2022 at 2-1, boosted by the ability to select consecutive first overall draft picks in Lawrence and Travon Walker.

Team-mate Dawuane Smoot said after the win: "It's been all worth it, going through a rebuild each year. Now, I feel like we're finally starting to get it.

"We just started. It's only three [games]. We still have a long season to go. But I feel like we're turning the corner to being something special."

Having crushed the Indianapolis Colts 24-0 at home in Week 2, Lawrence added: "It's awesome, two weeks in a row.

"I think the coolest thing is [after] a big win last week to see that same focus and intensity and preparation this week. That's a sign we're heading in the right direction. We've got to keep doing that week in, week out.

"Obviously, every week is going to present new challenges; you've just got to come ready to play. We did that, and it was awesome."

Patrick Mahomes has taken responsibility for the Kansas City Chiefs' inconsistent start to the season on offense despite a largely new cast of receivers.

The Chiefs fell to 2-1 with Sunday's 20-17 defeat to the previously winless Indianapolis Colts.

After dominating the Arizona Cardinals in a 44-21 Week 1 victory, Kansas City had just 20 points on offense in their 27-24 win over the Los Angeles Chargers and came up short against the Colts.

Only three times in Mahomes' career have the Chiefs scored fewer than 17 points in a regular season game.

The superstar quarterback completed only 20 of his 35 pass attempts for 262 yards and a single touchdown, also throwing an interception on the team's final drive as they sought to force overtime.

After scoring TDs on their first two visits to the red zone, the Chiefs returned only three points from their final two, with Matt Ammendola's fourth-quarter field-goal miss proving costly.

This inefficiency might be explained by the absence of Tyreek Hill – traded to the 3-0 Miami Dolphins – but Mahomes is not looking for excuses.

"I don't expect any growing pains," he said. "Obviously we have new players and you don't know everybody's going to respond to tough situations.

"We've got to gel all together. It starts with me. There were certain throws I was putting on guys' back hips instead of in front of him. There were certain situations where we were just barely off of it.

"Whenever you're playing a tough game like that, you have to execute at a higher level and we have to learn from it.

"Our schedule gets no easier. We have a hard game Sunday [against] Tampa next week with a great defense, so we have to get better quickly.

"And if we don't, we don't want these [losses] to start piling up. We want to make sure we get back on that winning train."

For the season, only the Detroit Lions (11) have scored more red zone TDs than the Chiefs (nine from 13 RZ drives), who rank eighth in red zone TD efficiency.

Last year, the Chiefs were 14th in efficiency, scoring 41 touchdowns from 68 red zone drives.