The decision to go for a touchdown on fourth down instead of kicking a go-ahead field goal "gave us the best chance to win", Baltimore Ravens head coach John Harbaugh insisted after the 23-20 defeat to the Buffalo Bills.

With the scores tied at 20-20 in the fourth quarter, the Ravens put together a 14-play, 93-yard drive from their own five-yard line to give themselves the opportunity to gain a precious late lead.

However, the drive stalled at the crucial moment and the Ravens faced a fourth-and-goal from the Bills' two-yard line with just over four minutes left in the game.

While a short field goal would have given the Ravens the lead, Harbaugh opted to go for the touchdown. The decision did not pay off as quarterback Lamar Jackson threw an interception, before Bills quarterback Josh Allen led a 77-yard drive to set up Tyler Bass for the game-winning field goal as time expired.

After the match, Harbaugh defended his late-game strategy, telling reporters: "[If] you kick a field goal there, now it's not a three-down game anymore, it's a four-down game.

"You're putting them out there, you're putting your defense at a disadvantage because they've got four downs to convert all the way down the field and a chance to again score seven, and then you lose the game on a touchdown.

"It didn't turn out that way, unfortunately, and we lost the game. So, hindsight, you could take the points, but if you look at it analytically, understand why we did it."

The decision sparked a furious touchline altercation between Harbaugh and cornerback Marcus Peters, with the former Kansas City Chief having to be pulled away from his coach.

But Harbaugh was not fazed by the interaction after the game, adding: "Emotions run high.

"We're on the same page, he and I. We have a great relationship, we have an honest relationship. I love him, I hope he still loves me. We'll see. I'm a Marcus Peters guy."

Tampa Bay Buccaneers' quarterback Tom Brady says he will "be all right" after appearing to injure his throwing arm in the 41-31 home loss to the Kansas City Chiefs.

Brady was strip-sacked by Chiefs safety L'Jarius Sneed in the second quarter, and the 45-year-old signal-caller immediately grabbed at his right arm before making his way to the sideline.

Despite the initial fears, Brady never missed a play and finished the match with season-highs of 385 yards and three touchdowns in defeat.

And Brady was not worried about his arm after the game, saying: "I'll be all right. It's football."

The Bucs' defeat to the Chiefs drops them to 2-2, though they remain atop the NFC South by virtue of their 1-0 record in divisional games.

They could surrender their position next Sunday though as the team second in the division, the 2-2 Atlanta Falcons, travel to face Brady's men at Raymond James Stadium.

There are fears of a serious knee injury for Denver Broncos running back Javonte Williams, who head coach Nathaniel Hackett confirmed will undergo an MRI.

Williams was forced out of Sunday's 32-23 loss to the Las Vegas Raiders with a right knee injury after being floored by defensive end Maxx Crosby in the first play of the third quarter.

The 22-year-old, who entered the game as the Broncos' leading rusher with 176 yards through three games, was unable to put full weight on his injured leg and taken to the locker room on a cart.

Williams was seen on crutches after the game and while Hackett would not elaborate on the extent of the injury amid fears of a lengthy stint on the sidelines, he confirmed he will need scans on Monday.

"We're still evaluating," Hackett said. "We want to be sure we get MRIs and get a feel there."

Broncos quarterback Russell Wilson added: "Obviously seeing Javonte go down, that hurt. Hopefully he'll be OK.''

Williams ran for 28 yards on 10 carries in Sunday's game. He has been the Broncos' second-leading receiver with 16 catches for 76 yards this season.

The Raiders' win marked Josh McDaniels' first as head coach of the franchise, coming against the team he led for almost two years before being sacked in December 2010 after losing 12 of his last 17 games with Denver.

"They gave me a great opportunity at a young age and, if anything, I look at it like it was a blessing because I learned so much from it," McDaniels told reporters.

"That made me better and I've been forever grateful to [owner] Mr [Pat] Bowlen for what he gave me an opportunity to do. Unfortunately, I didn't do well enough with it, but hopefully I've learned from it."

The Green Bay Packers got the victory but it was far from pretty as Aaron Rodgers had a poor night and the quarterback admitted that "way of winning is not sustainable".

The Packers won 27-24 in over-time against the New England Patriots, who were fielding a third-string rookie quarterback in Bailey Zappe for the majority of the game.

Green Bay trailed 10-7 at the long break after Rodgers had the lowest passer rating (11.2) of any half in any game he has started throughout his career, including a pick-six right on half-time. That was only the fourth pick-six of Rodgers' career and second at Lambeau Field.

Eventually, Rodgers got the Packers off the hook, driving them down the field in over-time to set up Mason Crosby's 31-yard game-winning field goal.

Rodgers finished the game with a completion rate of 60 per cent on 21-of-35 passing for 251 yards, two touchdowns and an interception.

"This way of winning, I don't think is sustainable because it puts too much pressure on our defense," Rodgers told reporters. "Obviously, I've got to play better and will play better.

"I think we're going to have to play a little bit better against starting quarterbacks and if our defense isn't playing as well as they can."

On his poor first-half, Rodgers added: "I settled in and usually don't have two terrible halves, so I kind of returned to the form I expect from myself, and we started moving the football."

The win means the Packers improve to a 3-1 record, with running back Aaron Jones playing a key role with 110 rushing yards on 16 carries.

Green Bay may have wrapped up the win in regulation time when Rodgers found Romeo Doubs with a 40-yard pass in the endzone with 2:02 remaining, but the rookie wide receiver clearly did not secure the catch.

Despite that, Packers head coach Matt LeFleur threw the red flag to challenge what he thought was a touchdown, costing his side a timeout that would have helped his side win in regulation time.

"I'm not too proud of that moment," LaFleur said. "That was an emotional decision, and I think it's a great learning lesson that you can never make those emotional decisions in the heat of battle.

"You know better. You've got to survive the ground. [Packers assistant quarterbacks coach] Connor Lewis was in my ear, he's up in the box and he's in my ear, and he said, 'I don't think so.' And he said that we shouldn't challenge it.

"Just made an emotional decision, and it was almost like throwing a Hail Mary. That could have came back and bit us in the butt."

The Packers next face the New York Giants (3-1) in London on Sunday.

Patrick Mahomes put on a masterclass with three touchdown passes as the Kansas City Chiefs improved to 3-1 with a 41-31 win over Tom Brady's Tampa Bay Buccaneers on Sunday.

Mahomes moved beyond 20,000 career passing yards, completing 23 of 37 attempts for 249 yards with three TDs, including an improvised flick for the second of Clyde Edwards-Helaire's TD.

The Chiefs blew away the Bucs early, scoring touchdowns from their opening two drives of the game including a Travis Kelce touchdown after 46 seconds following a Tampa Bay turnover.

Kansas City scored four touchdowns before half-time to lead 28-17 at the main break, representing the most combined points scored in the first half of a game this season.

Running back Edwards-Helaire had 19 carries for 92 yards with one touchdown, along with his one receiving TD, while Kelce made 92 yards from nine receptions with one TD. Kelce also moved past Rob Gronkowski into fifth overall for most career receiving yards for a tight end.

L'Jarius Sneed led the Chiefs' defensive display with eight tackles, including a sack on Brady leading to Noah Grey's one-yard rushing TD. Mahomes found Jody Fortson with 5:42 remaining in the third quarter for their fifth TD to make it 38-17.

Rachaad White and Leonard Fournette scored further TDs for the Bucs to limit the margin after wide receiver Mike Evans, who had eight receptions for 103 yards, scored their two first-half touchdowns.

Brady managed three touchdown passes, throwing for 385 yards on 39-of-52 passing, but the Bucs were always playing catchup after the Chiefs' early domination. The game marked only the fifth time in Brady's career he has scored 31 points and lost.

Cooper Rush became the first quarterback in the history of the Dallas Cowboys franchise to win his first four career starts on Sunday, earning praise from team owner Jerry Jones following a 25-10 victory over the Washington Commanders. 

Rush, however, could once again find himself backing up Dak Prescott next week with the two-time Pro Bowl selection getting closer to returning from a thumb injury. 

The Cowboys have won all three games with Rush under center after Prescott sustained a fractured right thumb in a season-opening 19-3 loss to the Tampa Bay Buccaneers on September 11. 

The undrafted Rush has completed 55 of 89 passes (61.8 percent) for 673 yards while throwing four touchdowns and no interceptions in those three consecutive victories. 

"I can't say enough about his play," Jones said. "What it has possibly done for this team this season to give us a chance to sit here after these last three ball games and maybe have the opportunity we've got for the rest of the year. 

"It's amazing. It's far more than what I would've expected." 

Jones has said that Prescott will return as the starter once healthy, but he isn’t sure when that will be despite recent reports that it could happen next week when Dallas visits the defending Super Bowl champion Los Angeles Rams. 

"I can't give you anything there medically," Jones said after Sunday's win. "I don't think anyone knows how he's going to grip the ball but certainly, we feel a lot better the way Cooper is playing, the way our team is playing." 

The Las Vegas Raiders rode a massive game from running back Josh Jacobs to a 32-23 home win against the Denver Broncos, marking their first win of the season.

Desperate for a result after an 0-3 start, the Raiders largely played a risk-averse style as they trusted Jacobs to carry the ball 28 times for 144 yards and two touchdowns, while quarterback Derek Carr posted 188 yards and no touchdowns.

The Raiders led 19-16 at halftime after Russell Wilson completed first-half touchdown passes to both Courtland Sutton and Jerry Jeudy, but when starting running back Javonte Williams was forced to leave the game with an injury, the offense began to stall.

A pair of field goals gave the Raiders a 25-16 lead, which was trimmed to 25-23 when Wilson was able to scamper in for a three-yard rushing touchdown.

But the Raiders would not be denied, marching down the field one more time and punctuating it with Jacobs' second touchdown

The Broncos were yet to concede 100 rushing yards to any player in a single game this season, which was broken by Jacobs, and also had not faced a 100-yard receiver, which was broken by Davante Adams as he collected nine catches for 101 yards.

K.J. Hamler led the Broncos in receiving yards, and all 55 of his yards came on one catch as Wilson completed 17 of 25 passes for 237 yards and two scores.

Dynamic duo deliver for the Packers in overtime

Arguably the best running back duo in the league, Aaron Jones and A.J. Dillon were both strong in the Green Bay Packers' 27-24 overtime win against the New England Patriots.

After backup Patriots quarterback Brian Hoyer suffered an injury in the first quarter, it was up to rookie fourth-round pick Bailey Zappe to lead New England the rest of the way, and he was more than respectable. He completed 10 of 15 passes for 99 yards and a touchdown, leading two touchdown drives in the second half to force overtime.

Rookie Packers receiver Romeo Doubs was the man to tie the game at 24-24 with his 13-yard touchdown catch, giving him touchdowns in back-to-back games as he tries to establish himself as Rodgers' top target.

In overtime, the Packers mounted a 13-play, 77-yard game-winning drive that featured seven runs, with Jones reaching 110 yards on 16 carries while Dillon had 73 yards on 17 carries.

Rodgers finished with a solid line of 21 completions from 35 attempts with 251 yards, two touchdowns and one interception.

The Buffalo Bills took advantage of a questionable fourth-quarter decision to defeat the Baltimore Ravens 23-20 on the road on Sunday.

In a game played in difficult, rainy conditions, both star quarterbacks completed one touchdown pass each.

Baltimore's Lamar Jackson dished off a shovel pass to J.K. Dobbins in the first quarter, and Dobbins' second touchdown, this time on the ground, helped build a 20-3 lead in the second period.

Buffalo's Josh Allen found Isaiah McKenzie in the seconds before half-time for what would end up being his only touchdown pass of the game, but he scored with his legs on an 11-yard rush late in the third to tie things at 20-20.

With scores even in the fourth quarter, the Ravens put together a 14-play, 93-yard drive starting from their own five-yard line, but after Dobbins' attempt at his third touchdown was stopped for a loss, the home side were forced into a tough decision.

While they could have kicked a chip-shot field goal and taken the lead, they instead opted to throw for it on fourth down, resulting in a turnover, handing the Bills the ball with four minutes remaining, needing just a field goal to win it.

A 20-yard completion to Dawson Knox and a roughing the passer call on the Ravens defense moved the ball up the field quickly, and with the ball on the one-yard line, the road team decided to play it smart and kneel to set up a game-winning field goal from Tyler Bass as time expired.

Both quarterbacks also ended up leading their teams in rushing, with Allen totalling 70 rushing yards from 11 carries, while Jackson finished with 11 carries for 73 yards.

Eagles force five turnovers to remain undefeated

The last undefeated team in the league stayed that way after the Philadelphia Eagles defeated the rising Jacksonville Jaguars 29-21.

Philadelphia's defense was the story of the game, recovering four fumbles and securing one interception, with Haason Reddick posting two sacks, two forced fumbles and two fumble recoveries.

On offense, Miles Sanders was a workhorse in the Eagles backfield, carrying the ball 27 times for 134 yards and two touchdowns, while A.J. Brown led both teams in receiving with five catches for 95 yards.

For the Jaguars, Jamal Agnew caught both of Trevor Lawrence's touchdown passes, although the impressive young quarterback completed just 11 of his 23 passes in the rain.

Pickett debuts as Steelers fall to the Jets

After a lacklustre first half where the Pittsburgh Steelers could only score a pair of field goals, first-round draft pick Kenny Pickett was brought in for his NFL debut as his side ended up losing to the New York Jets 24-20.

Pickett, who replaced Mitchell Trubisky, enjoyed a bright start as he ran in for two short-range rushing touchdowns to turn a 10-6 deficit into a 20-10 lead. While he completed 10 of his 13 passes, those three incompletions ended up as three interceptions to allow the Jets back into the game.

In his first game this season after returning from injury, Zach Wilson manufactured a touchdown pass to Corey Davis to cut the margin to 20-17, before going six-for-six through the air on the final drive to set up a one-yard, game-winning touchdown run from rookie Breece Hall.

Victory at Tottenham Hotspur Stadium could not have come in a more dramatic style for the Minnesota Vikings, who took the lead with 24 seconds remaining on Sunday and saw the New Orleans Saints endure a double doink with the last kick of the game.

The 28-25 result takes the Vikings to 3-1 for the season, with the last two wins coming by less than a single score, needing two fourth-quarter touchdowns against the Detroit Lions in Week 3.

In the opening weeks, Justin Jefferson's impact on the offense was limited. Two touchdowns and 184 receiving yards against the Green Bay Packers in Week 1 did not go unnoticed, with the Philadelphia Eagles and Detroit Lions often putting an extra man on him to quell his impact.

Those two games combined for just 62 receiving yards and only 50 per cent completion when Jefferson was the targeted receiver. Against the Saints, and Marshon Lattimore, the pendulum swung in the opposing direction again.

Lattimore, one of the league's premier cornerbacks, is not a player who needs an additional defender alongside him, but he lost the matchup in London against Jefferson despite numerous opportunities to stand out – Kirk Cousins targeting his receiver on 13 occasions, more than any other game this season.

Ten of those were successful, with Jefferson notching up 147 receiving yards, including a stunning 41-yard reception that teased the sort of partnership he can have with his quarterback, and punching in a touchdown run for three yards.

That was not just a targeted opportunity, though, with head coach Kevin O'Connell detailing after the game how the plan was to always get Jefferson involved as much as possible after a frustrating few weeks.

"No matter what we had to do today, within reason, within our normal offense, we were going to get him going," O'Connell said.

"We knew he was going to be matched up against a premier player at his position in Marshon Lattimore. I have a ton of respect for him, how he plays and competes. But we wanted to give Justin some more one-on-one opps when we saw them. Obviously, it allowed him to help the other guys as well on some of those early downs."

One on one, Jefferson is a player who can win his battles with the best, as shown with his matchup against Lattimore, but he needs to be brought into the game more by Cousins. While the receptions and the yards were there against the Saints, it could, and should, have been a more comfortable match.

Cousins knows as much, saying after the game: "Twice I think Justin was open for touchdowns and we didn't connect. The plays are there to make, and we didn't connect. That's disappointing."

Jefferson, for his part, needs to demand the ball and the big plays more. Now in his third year with the Vikings offense, he has taken leadership responsibilities this season and it has shown, not letting the frustrations in the past two weeks knock him out of his stride and responding in style against the Saints.

Lewis Cine will remain in London for surgery and his recovery after suffering a broken leg in the Minnesota Vikings' victory against the New Orleans Saints at Tottenham Hotspur Stadium.

The rookie safety suffered the injury during a special teams play in the first quarter, requiring oxygen on the field and leaving a significant hole for the team to fill in the locker room.

Speaking after the game, head coach Kevin O'Connell confirmed that Cine had suffered a lower leg fracture and the team have opted for him to stay behind in London for his treatment, along with members of the Vikings team.

"It's a very tough moment for our team. Obviously, he's a guy that from day one has been a personal favourite of mine," he said.

"He did everything we asked and was continuing to progress in his rookie year, really having a dynamic role for us on teams.

"He did have a lower leg fracture. We got him the immediate medical care at a local hospital. Everything I've been told, the care, obviously the local folks here, they have been phenomenal with him.

Arizona Cardinals defensive linesman J.J. Watt said he would play against the Carolina Panthers on Sunday after undergoing a heart procedure.

Watt spoke out ahead of his team's game to reveal he had to have his heart shocked back into rhythm after lapsing into atrial fibrillation on Wednesday.

The former Houston Texans man said he was disclosing the news because the information had been leaked.

"I was just told somebody leaked some personal information about me and it’s going to be reported on today," Watt wrote on Twitter.

"I went into A-Fib on Wednesday, had my heart shocked back into rhythm on Thursday and I'm playing today. That's it."

A three-time NFL Defensive Player of the Year during his time in Texas, Watt is in his second season with the Cardinals.

A double doink with the last kick of the game saw the New Orleans Saints fall to a 28-25 defeat against the Minnesota Vikings in London.

The Saints defence kept Vikings quarterback Kirk Cousins' impact on the game limited for the majority, before crucial plays in the fourth quarter saw the game turn on its head on numerous occasions.

Justin Jefferson punched the Vikings in front, but the extra point was missed, with the Saints then stopped by the Vikings defense, though Wil Lutz struck a field goal from 60 yards to tie the game.

The Vikings pulled ahead from the following drive with Joseph kicking a fifth field goal of the game, but there was still time for more drama, Lutz striking the left upright and the crossbar with a 61-yard attempt with the final kick of the game.

The contest was tied at the two-minute warning before half-time, Chris Olave's first career touchdown cancelling out Alexander Mattison's opener on the first drive, and the Vikings pushed ahead with three field goals, including two in the final 70 seconds of the half.

The Saints finally burst into action with a 78-yard drive down the field in the third quarter, the highlight being Andy Dalton's 33-yard throw to Marquez Callaway, and Latavius Murray punched in from a yard to bring the game to within a score.

That sparked new life into the Saints, despite another Vikings field goal, Taysom Hill putting the designated home side ahead before New Orleans moved three ahead with a successful two-point conversion, though Jefferson's three-yard reception put the Vikings ahead again.

A 60-yard field goal from Lutz tied the game at the start of the two-minute warning, but Joseph stepped up again to deliver with his kick.

The Saints then faced defeat in agonising fashion as the last-gasp effort from Lutz struck the upright and bounced off the crossbar to decide the game as the Saints fell to 1-3 for the season.

The unaffiliated neurologist who cleared Miami Dolphins quarterback Tua Tagovailoa of concussion during last week's game against the Buffalo Bills has been fired.

ESPN is reporting that the dismissal came about due to "several mistakes" being discovered in his evaluation of the Dolphins' QB, who underwent tests at half-time of the game before playing out a 21-19 win.

Tagovailoa, however, suffered a scary concussion in Miami's next game, Thursday's 27-15 loss to the Cincinnati Bengals, having been stretchered off and taken to hospital in the second quarter.

The NFL Players' Association (NFLPA) launched an investigation into a potential protocol violation after the Dolphins-Bills game, which remains ongoing.

The NFL and NFLPA put out a joint statement on Saturday stating a desire to improve the concussion protocol process.

"The NFL and the NFLPA agree that modifications to the concussion protocol are needed to enhance player safety," the statement said.

"The NFL and the NFLPA agree that The NFLPA's Mackey-White Health & Safety Committee and the NFL's Head Neck and Spine Committee have already begun conversations around the use of the term 'Gross Motor Instability' and we anticipate changes to the protocol being made in the coming days based on what has been learned thus far in the review process.

"The NFL and NFLPA share a strong appreciation for the unaffiliated neurotrauma consultants who contribute their time and expertise to our game solely to advance player safety. This program has made our game safer for the athletes who play it for the past 12 seasons."

Dolphins head coach Mike McDaniel had defended his and his side's decision to allow Tagovailoa to play on against the Bills, insisting he had been passed protocols and been cleared by the independent neurologist.

The New Orleans Saints have downgraded quarterback Jameis Winston from doubtful to out for Sunday's game against the Minnesota Vikings in London. 

Winston did not practice all week due to back and ankle injuries, leaving veteran Andy Dalton as the Saints' starter when they kick off at Tottenham Hotspur Stadium. 

New Orleans are dealing with several key injuries on offense, also ruling out starting left guard Andrus Peat due to a concussion and wide receiver Michael Thomas due to a foot injury. 

Running back Alvin Kamara is listed as questionable with ailing ribs but is expected to play. 

Winston rallied New Orleans to a 27-26 win over the Atlanta Falcons in Week 1 but has thrown five interceptions to just two touchdowns in the Saints' two losses since. 

Tight end and gadget quarterback Taysom Hill could see a larger share in the Saints' offense with Winston sitting.

The Saints' opponents received good injury news on Friday when Vikings running back Dalvin Cook was cleared to play despite a shoulder injury. 

Sunday's contest will be the first of three NFL games in London this year. The New York Giants and Green Bay Packers play at Tottenham Hotspur Stadium on October 9, and the Denver Broncos and Jacksonville Jaguars will play at Wembley on October 30.

The Cleveland Browns ruled defensive end Myles Garrett out for their Week 4 visit to the Atlanta Falcons after the star pass rusher sustained multiple injuries in a car accident on Monday.

Earlier in the week, the Browns had listed Garrett as questionable, but they announced on Saturday he would sit. 

Garrett suffered a sprained shoulder and strained biceps in the one-vehicle crash and was hospitalised for several hours after his car went off the road and flipped over.

Speaking to reporters for the first time since the crash, Garrett called it "a hell of an event" on Saturday. 

"I feel grateful to be here with what I saw right after and [in] the pictures," Garrett said.

"I'm just grateful not only that I'm alive but that I was able to have so much of my family and the support system that was around me to keep me locked in and keep me focused on taking things day by day."

Police issued Garrett a citation for driving 65 miles per hour in a 45mph zone. 

Garrett said he swerved to avoid hitting an animal and lost control of his Porsche when he "overcorrected" his steering on a wet road. 

All week, Garrett's team-mates have expressed more concern about his wellbeing than his ability to take the field on Sunday. 

"In the grand scheme of life, the best thing is that he's OK," Cleveland quarterback Jacoby Brissett said earlier this week. "When I texted him, I was like, 'man, I'm just glad you're alright'."

Garrett had a career season in 2021 with 16 sacks, 33 quarterback hits and 17 tackles for loss. He has made a solid start this year as he leads the Browns (2-1) with three sacks and five quarterback hits while being tied for the team lead with four tackles for loss and one forced fumble.

"I know he probably wants to [play]," Browns safety John Johnson III said. "But if you asked me, I think he just personally should just sit it out. I think he should just take it easy, man."