Hubert Hurkacz was the highest-profile casualty on day four of the Wimbledon men's singles, with the seventh seed forced to retire injured during his clash with Arthur Fils.
The Pole beat Roger Federer on the way to reaching the semi-finals in 2021, while he was runner-up to new world number one Jannik Sinner in Halle last month.
However, when trailing by two sets to one against his French opponent, Hurkacz sustained a knee injury during the tie-break in the fourth.
Despite valiantly attempting to battle on, he aggravated the problem further soon after when diving for a return, and was subsequently unable to continue with Fils advancing to round three.
There, he will play Alex de Minaur after the ninth seed enjoyed a straight-sets victory over Jaume Munar.
Fourth seed Alexander Zverev also prevailed in three sets as he continued his rich vein of form. The Italian Open champion, who was also runner-up to Carlos Alcaraz at Roland-Garros, was a commanding 6-1 6-2 6-4 winner over Marcos Giron.
Next up for him is Cameron Norrie after the 2022 semi-finalist ousted compatriot Jack Draper in a battle of the Brits on No.1 Court.
Eastbourne champion Taylor Fritz overcame Arthur Rinderknech in four sets, as did 15th seed Holger Rune against Thiago Seyboth Wild.
Meanwhile, Grigor Dimitrov recovered from two sets down to beat Juncheng Shang in a decider. The 2014 semi-finalist will now play Gael Monfils, who completed a straight-sets victory over fellow veteran Stan Wawrinka.
Although, there was no joy for 11th seed Stefanos Tsitsipas. The two-time major finalist was beaten in four sets by world number 87 Emil Ruusuvuori.
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