St Louis Cardinals ace pitcher Adam Wainwright was nearly flawless as he led his side to a 9-0 Opening Day shutout of the visiting Pittsburgh Pirates.
Wainwright pitched six scoreless innings, giving up five hits and no walks before being relieved to begin the seventh inning, finishing with 81 pitches.
It was far from a stressful game for the home side, scoring in the first inning through a Tyler O'Neill RBI single, before O'Neill smashed a three-run bomb over the wall an inning later to lead 4-0 through two frames.
The middle innings moved quickly as neither team was able to string baserunners together, but the Cardinals gave the home fans some more to cheer for in the eighth inning with home runs to Tommy Edman and Nolan Arenado.
J.T. Brubaker took the loss for the Pirates, finishing with four hits, three walks and four earned runs in three innings of work.
Super Suzuki wins debut
The Chicago Cubs' high-profile international signing, Seiya Suzuki, collected a hit and two walks from four at-bats in a 5-4 home win against the Milwaukee Brewers.
Kyle Hendricks pitched well for the home side, conceding one earned run to go with seven strikeouts before being withdrawn in the sixth inning.
The big moment for Suzuki came as he led-off the fifth inning, sending a base hit to shallow left field for his first career knock after signing a five-year, $85million deal out of the Japanese league this off-season.
The Bobby Witt Jr era begins in Kansas City
While Suzuki is favourite to take home the NL MVP, the Kansas City Royals' Bobby Witt Jr is the favourite in the AL, and delivered on debut in his side's 3-1 home win against the Cleveland Guardians.
After three outs from his first three at-bats, Witt delivered when it mattered, finding the gap with a RBI double in the eighth inning to give his side a 2-1 lead, and then came around and scored himself to finish it off.
Ohtani makes history in Angels loss
It was not a great Opening Day for the Los Angeles Angels, but reigning AL MVP Shohei Ohtani made history once again.
In the Angels' 3-1 loss to the Houston Astros, Ohtani became the first player to start on the pitchers' mound and lead-off the batting, throwing and facing Los Angeles' first pitch of the season.
He finished with nine strikeouts and one earned run before being withdrawn in the fifth inning after 80 pitches, while going zero-for-four from his plate appearances.
Thursday's results
Atlanta Braves 3-6 Cincinnati Reds
St Louis Cardinals 9-0 Pittsburgh Pirates
Kansas City Royals 3-1 Cleveland Guardians
Chicago Cubs 5-4 Milwaukee Brewers
New York Mets 5-1 Washington Nationals
Arizona Diamondbacks 4-2 San Diego Padres
Los Angeles Angels 1-3 Houston Astros
Red Sox at Yankees
The two historic rivals will kick off their seasons at Yankee Stadium on Friday in the first scheduled game of the day.