The Oakland Athletics scored three runs in the bottom of the 12th inning to beat the Red Sox 7-6, snapping Boston's eight-game winning streak.
Tony Kemp's sacrifice fly provided the winning margin after a Seth Brown single and Jed Lowrie double negated the two runs the Red Sox had scored to take the lead in the third extra frame.
Brown finished a home run shy of the cycle, driving in a run with all three of his hits.
Kike Hernandez hit his 10th home run of the season and drove home two runs for Boston.
Walker, Mets roll past Yankees
Taijuan Walker did not allow a hit until Aaron Judge's home run with one out in the sixth inning as the New York Mets opened their rain-delayed Subway Series against the Yankees with an 8-3 win.
Austin Slater's two-run homer in the eighth inning gave the San Francisco Giants a 6-5 victory over the Arizona Diamondbacks to maintain a half-game edge in the National League (NL) West.
The Los Angeles Dodgers' bullpen turned in five scoreless innings as the defending World Series champions weathered a rain delay to defeat the Washington Nationals 5-3 for their eighth win in a row.
Joey Votto and Tyler Naquin homered as the Cincinnati Reds sent the Chicago Cubs to an eighth straight defeat with a 3-2 triumph that moved the Reds up into second place in the division for the first time since April 22.
The division-leading Milwaukee Brewers won their 11th in a row with an 11-2 rout of the Pittsburgh Pirates as Omar Narvaez had five hits and Avisail Garcia drove in five runs.
Rays, Indians drop fifth in a row
The Tampa Bay Rays lost a chance to recover some ground on the Red Sox when they surrendered five runs in the sixth inning of a 6-3 loss to the Toronto Blue Jays for their fifth consecutive defeat.
The Cleveland Indians also have lost five in a row and are on the verge of a four-game sweep by the Houston Astros after a 3-2 defeat Saturday.
No-look Story
Colorado Rockies shortstop Trevor Story did not need to see Harrison Bader to get him out, completing a pick-off of the St Louis Cardinals outfielder with a no-look tag.
Saturday's results
Philadelphia Phillies 4-2 San Diego Padres
New York Mets 8-3 New York Yankees
Los Angeles Dodgers 5-3 Washington Nationals
Milwaukee Brewers 11-2 Pittsburgh Pirates
Toronto Blue Jays 6-3 Tampa Bay Rays
Detroit Tigers 11-5 Chicago White Sox
Cincinnati Reds 3-2 Chicago Cubs
Houston Astros 3-2 Cleveland Indians
Miami Marlins 3-2 Atlanta Braves
Kansas City Royals 6-3 Minnesota Twins
Colorado Rockies 3-2 St Louis Cardinals
Oakland Athletics 7-6 Boston Red Sox
Los Angeles Angels 4-1 Baltimore Orioles
San Francisco Giants 6-5 Arizona Diamondbacks
Texas Rangers 7-3 Seattle Mariners
Mets at Yankees
New York will have plenty of baseball to watch on Independence Day as the Yankees host the Mets in a doubleheader highlighted by a Gerrit Cole-Marcus Stroman pitching matchup in the first game.
Milan 3-1 Hellas Verona: Leao double condemns visitors to Serie A relegation play-off
Milan signed off the Serie A season with a 3-1 victory as Rafael Leao's double condemned Hellas Verona to a relegation play-off with Spezia.
The Rossoneri wrapped up a frustrating campaign on a winning note at San Siro, with a late Leao brace enough to seal three points.
Milan had already secured Champions League football for another term but struggled at times against the visitors, who cancelled out Olivier Giroud's first-half penalty through Marco Faraoni's 72nd-minute strike.
Yet Leao struck in the 85th minute and again seven minutes later, leaving Verona to face a relegation decider with Spezia, who succumbed to a late 2-1 loss at Roma.
Udinese 0-1 Juventus: Chiesa strikes but Bianconeri miss out on top-six Serie A finish
Juventus missed the chance to finish sixth in Serie A despite Federico Chiesa's strike sealing a 1-0 victory over Udinese at Dacia Arena.
After Paulo Dybala's late penalty helped Roma to a 2-1 victory over Spezia, Massimiliano Allegri's side were unable to leapfrog the Giallorossi and were forced to settle for a seventh-place finish in the league.
Chiesa's second-half strike was the difference for Juve, who were deducted 10 points for violating financial rules earlier in a rollercoaster campaign, but they suffered their lowest finish in Serie A for 12 years.
Meanwhile, Udinese finished 12th in Serie A following their 10th defeat in 12 meetings with the Old Lady.
Udinese had lost their last three but went close after just four minutes when Beto somehow headed Florian Thauvin's cross over from inside the six-yard box.
Federico Chiesa’s deflected effort hit the side-netting before Juve saw a headed opportunity go begging as Leonardo Bonucci nodded against the crossbar from seven yards out following Arkadiusz Milik's flick-on.
Chiesa continued to cause Udinese problems down the left flank, yet the sides headed into half-time goalless after a profligate showing from both teams.
Juve squandered a great chance to break the deadlock just after the hour mark, Adrien Rabiot firing wide despite being found by Milik in acres of space inside the box.
But the visitors eventually opened the scoring in the 68th minute, Chiesa receiving the ball from Manuel Locatelli before bending a brilliant shot into the bottom-right corner.
Locatelli and Angel Di Maria went close to extending the advantage and though the single goal was enough, former Juve forward Dybala was to snatch sixth place for Roma from under his old club's nose.
Celta Vigo 2-1 Barcelona: Veiga double secures safety as Celestes stun champions
Gabri Veiga scored twice as Celta Vigo clinched survival with a surprise 2-1 win over champions Barcelona on a dramatic final day of the season in LaLiga.
Starting the game in 17th, Celta knew a victory would preserve their top-flight status, and Carlos Carvalhal's men took charge as Veiga struck either side of the break.
The 21-year-old drilled into the bottom-left corner to spark wild scenes at the Balaidos shortly before half-time, then saw a fortuitous 65th-minute cross sail in off the far post.
Celta clung on after Barca substitute Ansu Fati nodded home, clinching a 13th-placed finish as Real Valladolid went down, while Barca ended the campaign 10 points clear of runners-up Real Madrid.
Barca thought they had an 11th-minute lead when Franck Kessie latched onto a rebound to beat Ivan Villar, only for a VAR review to show the midfielder was offside.
Oscar Rodriguez skewed a first-time shot just wide as Celta went close, while Robert Lewandowski saw a curling effort clip the outside of Villar's left post.
The offside flag thwarted Rodriguez as he capitalised on Marc-Andre ter Stegen's error to flick home, but Celta did go ahead on the stroke of half-time when Veiga raced onto Haris Seferovic's pass to finish across goal.
With Barca struggling for momentum, Veiga put Celta 2-0 up when his mishit cross from the right swerved over substitute goalkeeper Inaki Pena, clipping the woodwork before nestling in the back of the net.
Fati ensured a nervous finish by heading in Ousmane Dembele's cross 11 minutes from time, but Celta clung on to ensure another season of top-flight football.
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