Fernando Tatis Jr. did it again, hitting a two-out, three-run home run in the ninth inning to tie the game before the San Diego Padres got another long ball in the 12th to defeat the Houston Astros 11-8.
Houston led 6-1 after seven before the Padres scored two in the eighth, then three on the Tatis shot in the ninth to send the game to extra innings.
The teams traded runs in the 10th and 11th innings before Wil Myers homered with one out in the 12th -- two batters after Houston intentionally walked Tatis -- to provide the winning margin.
The victory kept San Diego (34-19) ahead of the Tampa Bay Rays (33-20) for the best record in MLB.
Giants pound rival Dodgers
The San Francisco Giants pounded out 16 hits as they defeated the rival Los Angeles Dodgers 11-6 for their second consecutive win after dropping four straight to the defending World Series champions. Logan Webb allowed only one hit and did not walk a batter while striking out seven for the Giants.
The New York Mets scored seven runs in the sixth inning to run away from the Atlanta Braves in a 13-2 rout. James McCann had four hits, including the first of five home runs the Mets hit in the game, while the entire Braves lineup managed only one extra-base hit.
For the second consecutive day, a young Detroit Tigers starter shut down New York Yankees batters, as Spencer Turnbull allowed only three singles in a 6-1 Detroit win.
Diamondbacks, Orioles skids continue
A late rally came up short as the Arizona Diamondbacks fell 7-4 to the St Louis Cardinals for their 13th consecutive defeat, while the Baltimore Orioles were swept in a double-header by the Chicago White Sox to run their losing skid to 12 straight.
The Pittsburgh Pirates held Colorado Rockies batters to just six hits in 49 at-bats in sweeping a double-header with 7-0 and 4-0 victories. Colorado hitters struck out 14 times after their best player, shortstop Trevor Story, landed on the injured list earlier in the day due to right elbow inflammation.
Rendon on the run
Los Angeles Angels third baseman Anthony Rendon had to cover a lot of ground to get to this foul pop off the bat of the Oakland Athletics' Matt Olson, then made a blind heave to double off Tony Kemp.
Saturday's results
Chicago Cubs 10-2 Cincinnati Reds
Boston Red Sox 3-1 Miami Marlins
Detroit Tigers 6-1 New York Yankees
Minnesota Twins 6-5 Kansas City Royals
Tampa Bay Rays 5-3 Philadelphia Phillies
Chicago White Sox 7-4 Baltimore Orioles
Chicago White Sox 3-1 Baltimore Orioles
San Diego Padres 11-8 Houston Astros
Los Angeles Angels 4-0 Oakland Athletics
St Louis Cardinals 7-4 Arizona Diamondbacks
Seattle Mariners 3-2 Texas Rangers
San Francisco Giants 11-6 Los Angeles Dodgers
Pittsburgh Pirates 7-0 Colorado Rockies
Pittsburgh Pirates 4-0 Colorado Rockies
Milwaukee Brewers 4-1 Washington Nationals
Milwaukee Brewers 6-2 Washington Nationals
New York Mets 13-2 Atlanta Braves
Toronto Blue Jays-Cleveland Indians (postponed)
Giants at Dodgers
Kevin Gausman (5-0, 1.53 ERA) looks to stay unbeaten for the San Francisco Giants as they visit Clayton Kershaw (7-3, 2.94) and the Los Angeles Dodgers.