A new day but the same result for struggling World Series champions the Los Angeles Dodgers, who suffered a 6-5 walk-off defeat to the Chicago Cubs on Wednesday.
The Dodgers were condemned to walk-off misery in game two of Tuesday's doubleheader and the slumping MLB holders experienced the same fate midweek.
Anthony Rizzo hit an RBI single in a two-run 11th inning to lift the Cubs, who completed a sweep of the Dodgers at Wrigley Field in Chicago.
The Cubs swept the Dodgers – who lost for the 13th time in 17 games following a 13-2 start to the season – at Wrigley Field for the first time since 2008.
Meanwhile, Baltimore Orioles ace John Means entered the MLB history books after throwing a no-hitter against the Seattle Mariners.
Means threw the Orioles' first solo no-hitter since Jim Palmer in 1969 as Baltimore blanked the Mariners 6-0.
It was an almost perfect performance for Means, who retired all 27 batters he faced in Seattle but did allow a baserunner when Sam Haggerty reached on a third-strike wild pitch in the third inning.
Means is the first pitcher to throw a non-perfect no-hitter in which the team did not record a walk, hit by pitch or error.
According to Stats Perform, Means is also the second pitcher in American League (AL) history to throw a no-hitter with 12-plus strikeouts and 0 walks, joining Felix Fernandez – who had a perfect game in 2012.
Fulmer follows in Ryan's footsteps
Detroit Tigers pitcher Michael Fulmer earned his first career save in a 6-5 win over the Boston Red Sox. Fulmer retied Bobby Dalbec and Kike Hernandez to snap Detroit's six-game skid. According to Stats Perform, Fulmer is the first pitcher to get a save the day after a start of less than an inning since Nolan Ryan in 1973.
Marcell Ozuna hit a grand slam to lead the Atlanta Braves past the Washington Nationals 5-3, while Didi Gregorius also managed a grand slam as the Philadelphia Phillies topped the Milwaukee Brewers 5-4.
Giancarlo Stanton stayed hot with a homer and four runs in the New York Yankees' 6-3 win against the Houston Astros. Stanton homered in back-to-back games for the first time since last July as the Yankees extended their winning streak to six games.
A's falter against Jays
The Oakland Athletics were leading the Toronto Blue Jays 3-2 before faltering. Toronto produced a five-run eighth inning to rally past the A's. Lou Trivino struggled in the eighth, allowing three hits, five runs – all earned – and two walks. Toronto won 9-4.
Ohtani the freak
Is there anything Shohei Ohtani cannot do? The two-way Los Angeles Angels star – returning to the mound – caught his own pitch in a fine example of his fielding and agility. Ohtani pitched five scoreless innings, giving up just one hit while striking out seven but the Angels still lost 3-1 to the Tampa Bay Rays.
Wednesday results
Cincinnati Reds 1-0 Chicago White Sox
Colorado Rockies 6-5 San Francisco Giants
Baltimore Orioles 6-0 Seattle Mariners
St Louis Cardinals 4-1 New York Mets
New York Mets 7-2 St Louis Cardinals
Miami Marlins 8-0 Arizona Diamondbacks
Atlanta Braves 5-3 Washington Nationals
New York Yankees 6-3 Houston Astros
Philadelphia Phillies 5-4 Milwaukee Brewers
Detroit Tigers 6-5 Boston Red Sox
Chicago Cubs 6-5 Los Angeles Dodgers
Texas Rangers 3-1 Minnesota Twins
Cleveland Indians 5-4 Kansas City Royals
San Diego Padres 4-2 Pittsburgh Pirates
Tampa Bay Rays 3-1 Los Angeles Angels
Toronto Blue Jays 9-4 Oakland Athletics
Blue Jays at Athletics
The Blue Jays will look to split their series away to the Athletics on Thursday. Blue Jays ace Ryu Hyun-jin starts, while the A's counter with Mike Fiers.