New York Mets ace Jacob deGrom matched an MLB record, but it was not enough to avoid a 1-0 loss to the Boston Red Sox.
DeGrom tied Nolan Ryan's record for most strikeouts through a pitcher's first five starts of a season, however, the Mets were beaten on Wednesday.
Mets star DeGrom tallied nine strikeouts over six innings to improve his five-game total to 59, matching Ryan's feat in 1978.
DeGrom, who has allowed two earned runs all season while boasting a National League (NL)-leading ERA (0.51), saw Christian Vazquez hit an early RBI double which produced the winning run in the second inning at Citi Field midweek.
World Series champions the Los Angeles Dodgers, meanwhile, snapped a three-game skid by shutting out the Cincinnati Reds 8-0.
Seeking to avoid a series sweep, the Dodgers benefited from a trademark Clayton Kershaw performance at home to the Reds.
Kershaw was dominant over seven innings, yielding just four hits while striking out eight batters with one walk as Justin Turner homered for the Dodgers.
Padres in 11-year first
The San Diego Padres humbled the Arizona Diamondbacks 12-3. During the rout, the Padres tallied seven successive hits without recording an out in the fifth inning – the first time they have managed to do so since April 2010 (also in the fifth).
A five-homer game from the Atlanta Braves inspired a 10-0 demolition of the Chicago Cubs. Marcell Ozuna homered in a four-run first inning, while Huascar Ynoa hit his first career home run in the fourth. Freddie Freeman posted his seventh home of the season, while Ozzie Albies and Austin Riley also went deep.
All good things must end as Matz struggles
Steven Matz had won his first four starts for the Toronto Blue Jays after being acquired from the Mets in January. However, Matz lasted less than four innings in an 8-2 defeat to the Washington Nationals. In George Springer's long-awaited Blue Jays debut, Matz gave up six runs and eight hits, including a three-run shot in the fourth inning.
Rizzo strikes out Freeman…
Anthony Rizzo versus Freeman. It is a showdown you do not often see but the Cubs star sensationally came out on top. In the bottom of the seventh inning, Rizzo took to the mound and struck out reigning NL MVP Freeman – his first career strikeout as a pitcher as both players smiled.
Wednesday's results
Minnesota Twins 10-2 Cleveland Indians
Miami Marlins 6-2 Milwaukee Brewers
Los Angeles Dodgers 8-0 Cincinnati Reds
Kansas City Royals 9-6 Pittsburgh Pirates
Boston Red Sox 1-0 New York Mets
New York Yankees 7-0 Baltimore Orioles
Washington Nationals 8-2 Toronto Blue Jays
Tampa Bay Rays 2-0 Oakland Athletics
Atlanta Braves 10-0 Chicago Cubs
Philadelphia Phillies 5-3 St Louis Cardinals
Los Angeles Angels 4-3 Texas Rangers
Houston Astros 7-5 Seattle Mariners
San Diego Padres 12-3 Arizona Diamondbacks
San Francisco Giants 7-3 Colorado Rockies
Detroit Tigers-Chicago White Sox (postponed)
Dodgers at Brewers
After returning to winning ways, the Dodgers (16-9) will open their series against the Brewers (14-10) on Thursday. Trevor Bauer gets the nod on the mound for the Dodgers, while Milwaukee's Eric Lauer starts.