Ciaran Frawley will make his first Test start in Ireland’s Guinness Six Nations clash with Wales after being selected in place of injured full-back Hugo Keenan.
The versatile 26-year-old won his two previous caps as a replacement, including playing the final four minutes of the championship curtain-raiser away to France.
Keenan has been virtually ever-present in his country’s number 15 jersey during the past three years but will miss Saturday’s match in Dublin due to a knee injury suffered in the round-two victory over Italy.
Head coach Andy Farrell, who has included uncapped Munster prop Oli Jager among the replacements, has made seven personnel changes to his starting XV from the 36-0 win over the Azzurri Italy on February 11.
Captain Peter O’Mahony, prop Tadhg Furlong and centre Bundee Aki return following injuries, while lock Tadhg Beirne, scrum-half Jamison Gibson-Park and flanker Josh Van Der Flier are also recalled.
Second-row James Ryan, flanker Ryan Baird, number eight Jack Conan and centre Stuart McCloskey drop to a bench containing a six-two split of forwards and backs.
Prop Finlay Bealham and scrum-half Craig Casey have been left out of the matchday 23 after starting against Italy.
Lock Iain Henderson, who suffered a foot injury playing for Ulster last weekend, is not involved, while centre Garry Ringrose remains absent after missing the opening two rounds with a shoulder issue.
Frawley has been battling Jack Crowley and Harry Byrne for action at fly-half but Farrell has limited back-up options at full-back due to Jimmy O’Brien and Mack Hansen being ruled out of the entire tournament.
The full debutant has played a total of just 44 minutes of international rugby, during cameos in last summer’s World Cup warm-up win over Italy and the 38-17 victory over Les Bleus at the start of the month.
Crowley continues in the number 10 role, partnering Gibson-Park, with Aki and Robbie Henshaw in midfield and Calvin Nash and James Lowe retained on the wings.
In the front row, returning tighthead Furlong will pack down alongside Leinster team-mates Andrew Porter and Dan Sheehan, ahead of the second row pairing of Joe McCarthy and Beirne.
Caelan Doris, who stood in as skipper last time out, reverts from openside flanker to number eight. Van der Flier returns to the number seven role, while O’Mahony is back in at blindside flanker.
Hooker Ronan Kelleher, prop Cian Healy and scrum-half Conor Murray complete the bench.
Ireland are seeking a third successive win in this year’s championship – and an 18th in a row at home – after launching their title defence with back-to-back bonus-point victories over France and Italy.
Opponents Wales began with narrow defeats to Scotland and England and have not won a Six Nations fixture in Dublin since 2012.
South Africa seal ODI series win against Ireland
South Africa claimed an emphatic 174-run victory to seal an ODI series triumph over Ireland ahead of the final game on Sunday in Abu Dhabi.
Having cruised to a 139-run victory in the opening encounter, the Proteas continued to avenge their shock T20I defeat against the same opponents last week with another commanding display.
South Africa made a strong start with the bat before Ryan Rickelton (40) fell in the 13th over, with Temba Bavuma (35) retiring hurt from the contest soon after.
Rassie van der Dussen (35) and Kyle Verreynne (67) also performed well, only for Tristan Stubbs to steal the show with 112 runs from 81 deliveries, handing the Proteas a strong grip on the encounter, with South Africa ending 343-4 from their 50 overs.
Ireland then made a dismal start to their run chase, losing five wickets in the opening 10 overs as Lizaad Williams and Lungi Ngidi ripped through their opening attack and had Ireland 50-5 early on.
Mark Adair (21) and Andy McBrine (10) momentarily halted the onslaught, but were soon sent on their way, with Gavin Hoey hitting 23 runs before he was bowled and caught by Ngidi (2-38).
Graham Hume and Craig Young's 52-run stand frustrated South Africa, only for the former to be bowled out by Bjorn Fortuin (2-36) with just under 20 overs remaining as Ireland ended all out for 169.
Data Debrief: Proteas on song
It was yet another strong display by South Africa, cruising to a comfortable victory in Abu Dhabi, with Stubbs and Williams starring with the bat and ball.
Stubbs' knock of 112 saw him record a maiden century in international cricket, ending with an impressive strike rate of 138.27.
Williams, meanwhile, continued where he left off from the first match, and now has seven wickets during the series so far.
South Africa beat Ireland in ODI opener to avenge T20I loss
South Africa cruised to a 139-run win over Ireland in the teams' first ODI in Abu Dhabi, with Lizaad Williams tearing through their opponents' batting order.
The Proteas approached Wednesday's contest reeling from a shock T20I defeat to Ireland on Sunday, with Ross Adair's maiden international century ensuring the two-match series ended 1-1.
There was not to be a repeat in the 50-over format, however, with Ireland's batting order collapsing after Ryan Rickelton (91) and Tristan Stubbs (79) guided an otherwise shaky South Africa to 271-9.
The Proteas started miserably by losing three wickets for 39 runs, Mark Adair taking two of them on his way to figures of 4-50.
But opener Rickelton stayed cool while the wickets tumbled around him, lasting 102 deliveries and allowing Stubbs to join in on the act with comfortably his best ODI score, dragging South Africa to a respectable total.
Ireland might have harboured hopes of a successful chase, but Paul Stirling's fourth-ball dismissal for just two runs set the tone, and a spate of four more wickets in the space of six overs dropped Ireland to 61-5.
Williams finished with figures of 4-32 from his 10 overs for the Proteas, who needed just 32 overs to finish off the tail and bring some much-needed positivity to their tour of the United Arab Emirates, which started with an ODI series loss to Afghanistan.
Data Debrief: Williams wins it
Rickelton and Stubbs carried South Africa to a score they were capable of defending despite no other batter scoring more than Bjorn Fortuin's 28 – seven scored 13 runs or fewer.
But it was Williams who made sure of the victory, taking three of the first four wickets to leave Ireland in a tailspin, then going on to record the best figures of his young ODI career.
In none of his previous five ODIs had Williams managed more than two wickets, while his 32 runs conceded were also his fewest in the format.
Stirling 'over the moon' after historic Ireland win over South Africa
Ireland captain Paul Stirling is "over the moon" after securing their first-ever T20I victory over South Africa, beating them by 10 runs.
Brilliant performances from brothers Ross and Mark Adair set them on course to the win, as they drew the two-match series 1-1.
Ross Adair scored his maiden international century, combining with Stirling for a superb opening partnership of 137, leading the team to 195-6, their highest T20I score against South Africa.
Mark Adair then followed up that performance with an impressive stand in the field, finishing with 4-31, before Graham Hume's 3-25 rounded off the triumph.
And Stirling was thrilled with how Ireland performed on both sides, particularly in the field.
"At halfway, we wanted an extra 15-20 runs," he said.
"They squeezed us, and we felt under-par. There was less dew [on Sunday] and we managed to get over the line.
"You need time at the crease to get the pace of the wicket. That is what won us the game.
"With new batters coming in, you always have a chance. We are absolutely delighted [with the win]. It could have gone either way. Over the moon [with the result] and hopefully we can bring it into the ODIs."
South Africa started brightly, with both Reeze Hendricks and Matthew Breetzke getting 51 after Ryan Rickelton's opening 36.
However, they soon collapsed after that, with none of the other eight batters able to reach double figures as they finished on 185-9.
Captain Aiden Markram admitted that fine margins cost them on Sunday, but he still found positives to take from the series.
"We thought it was chaseable for sure," he said. "Small moments in the game.
"It comes down to execution and if you can win those moments. When you lose wickets regularly…you want a 20-30-run partnership. They made it tough for us.
"Each guy will have a certain area to improve. We never really stop learning. Ultimately, making better decisions and winning games for South Africa."
The two sides now turn their attention to the three-match ODI series, which starts on Wednesday at the Zayed Cricket Stadium.
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