The reigning Super Bowl champions will kick off the NFL season in Thursday night's primetime slot on September 8, as the Los Angeles Rams host this season's Super Bowl favourites, the Buffalo Bills.
There will be plenty of the Rams in this season's marquee timeslots as the full 2022-23 schedule was released on Thursday, including a Monday night fixture against the Green Bay Packers in week 15, and a Christmas Day game against Russell Wilson's Denver Broncos six days later.
The Broncos will not have to wait long for their first eyebrow-raising matchup, travelling to take on Wilson's former team, the Seattle Seahawks, in the first Monday night fixture of the season.
Week one's third primetime game sees Tom Brady's Tampa Bay Buccaneers heading to 'Jerry World' to take on the Dallas Cowboys.
Patrick Mahomes – the man with the richest contract in the sport – will get his first primetime appearance of the season in week two's Thursday night showdown, as his Kansas City Chiefs host arguably Mahomes' only competition for best young quarterback, taking on Justin Herbert and the Los Angeles Chargers.
Four-time MVP Aaron Rodgers gets the Sunday night fixture in week two against the Packers' long-time rivals as the Chicago Bears come to town, and his week three matchup against Brady's Bucs will be must-see TV.
The Rams have the toughest strength-of-schedule based on their opponents' 2021-22 records (164-125, .567 winning percentage), while the Cowboys and the Washington Commanders are tied for the easiest schedule (133-155-1, .462 winning percentage).
Meanwhile, the Detroit Lions will be the only team in NFL this season to not have a primetime game.
The complete week one schedule features:
Buffalo Bills at Los Angeles Rams (Thursday night)
New Orleans Saints at Atlanta Falcons (Sunday afternoon)
New England Patriots at Miami Dolphins
Baltimore Ravens at New York Jets
Cleveland Browns at Carolina Panthers
Philadelphia Eagles at Detroit Lions
Pittsburgh Steelers at Cincinnati Bengals
Jacksonville Jaguars at Washington Commanders
San Francisco 49ers at Chicago Bears
Indianapolis Colts at Houston Texans
New York Giants at Tennessee Titans (Sunday late-afternoon)
Green Bay Packers at Minnesota Vikings
Las Vegas Raiders at Los Angeles Chargers
Kansas City Chiefs at Arizona Cardinals
Tampa Bay Buccaneers at Dallas Cowboys (Sunday night)
Denver Broncos at Seattle Seahawks (Monday night)