The Jacksonville Jaguars helped the Pittsburgh Steelers virtually secure a playoff place as they stunned the Indianapolis Colts in their regular-season finale.
Indianapolis needed only to beat a two-win Jaguars team to secure their place in the postseason.
History, however, was against Frank Reich's team, the Colts having not won in Jacksonville since the 2014 season.
And the Jags' home hoodoo over the Colts continued as Indianapolis quarterback Carson Wentz imploded in a 26-11 defeat.
Wentz was sacked six times in a game the Jaguars led the entire way, rookie first overall pick Trevor Lawrence throwing multiple touchdowns for the first time since Week 1.
The dagger effectively came when Lawrence capitalised on Wentz's lone interception, the former Philadelphia Eagle picked by Jags linebacker Damien Wilson in the third quarter.
Lawrence then successfully handled a high snap from center, rolled to his right and lofted a three-yard pass to Marvin Jones Jr, who made a leaping grab in the back of the endzone.
The Colts were eliminated from the playoffs after the Steelers beat the Baltimore Ravens in overtime. The Steelers will qualify unless the Los Angeles Chargers' game with the Las Vegas Raiders ends in a tie.
Despite the win, the Jaguars claim the number one pick in the 2022 draft by virtue of the Detroit Lions' win over the Green Bay Packers, who rested players for much of the game.
Titans take one seed
The Kansas City Chiefs kept the pressure on the Titans with their win in Denver on Saturday, but Tennessee did not waste the opportunity to clinch the one seed, though they received a scare from the lowly Houston Texans.
Tennessee surged to a 21-0 lead, only for the Texans to respond with 18 unanswered points of their own. Ryan Tannehill's fourth touchdown pass, on which he hit Julio Jones for the receiver's first touchdown as a Titan, gave them breathing room that proved enough as they hung on for a 28-25 win after Danny Amendola's second touchdown reception frayed the nerves.
Watt ties sack record as Steelers stay alive
Ben Roethlisberger bid a tearful farewell to Heinz Field in the Steelers' home finale on Monday, but his likely final season in the NFL looks like being extended into the Wild Card round.
The Steelers fought back from 10-3 down to lead 13-10 on a Roethlisberger pass to Chase Claypool and, though Justin Tucker's field goal forced overtime, the leg of Chris Boswell had the final say, giving the Steelers a 16-13 victory in a game that saw T.J. Watt tie Michael Strahan's single-season sack record as he took his tally to 22.5.
With Chargers head coach Brandon Staley saying they would not play for a tie that would punch the postseason ticket for them and the Raiders, the Steelers' spot seems virtually assured.