Monday's fixture between the Buffalo Bills and the Cincinnati Bengals has been officially suspended after Bills safety Damar Hamlin collapsed on the field and was taken away in an ambulance.
Hamlin, 24, had made a tackle on Bengals receiver Tee Higgins, and after briefly returning to his feet, he collapsed.
He remained down for over 10 minutes, and was seen receiving CPR before being loaded into an ambulance and taken to a local hospital.
All players and team personnel returned to the locker room and over an hour passed before the NFL decided to officially call off the rest of the night's proceedings.
A statement from the league confirmed Hamlin is in "critical condition".
It read: "Tonight’s Buffalo Bills-Cincinnati Bengals game has been postponed after Buffalo Bills' Damar Hamlin collapsed, NFL Commissioner Roger Goodell announced.
"Hamlin received immediate medical attention on the field by team and independent medical staff and local paramedics. He was then transported to a local hospital where he is in critical condition.
"Our thoughts are with Damar and the Buffalo Bills. We will provide more information as it becomes available.
"The NFL has been in constant communication with the NFL Players Association which is in agreement with postponing the game."
The game was called off halfway through the first quarter with the Bengals leading 7-3.
Warner hails Niners for 'standing tall' in nervy Seattle win
San Francisco 49ers linebacker Fred Warner hailed the team for standing tall on the road after they held off a Seattle Seahawks fightback for a crucial 36-24 win.
The Niners were in dire need of a victory after blowing double-digit fourth-quarter leads in losses to the Los Angeles Rams and Arizona Cardinals in Weeks 3 and 5.
They made a strong start to Thursday's meeting between two NFC West rivals, assuming a 23-3 lead early in the third quarter, as Brock Purdy threw a 76-yard catch-and-run touchdown to Deebo Samuel and another score to George Kittle.
However, the defending NFC champions let Seattle back in and saw their lead trimmed to six points by the start of the fourth, with the Seahawks reeling off 14 straight points then getting the ball back via a Rasheem Green interception.
However, they held firm and another two touchdowns – a second Purdy-Kittle link-up and a six-yard Kyle Juszczyk rush – ensured they improved to 3-3, level with Seattle.
Asked if doubts began to creep in as the Niners' lead shrunk, three-time All-Pro Warner said: "A thousand percent.
"It sucks, but yes, it was something that felt familiar for sure. We could go one of two ways right there.
"We could stand tall in a hostile environment and get the game that we got to get or we could settle for exactly how we've been playing the last couple losses."
The 49ers' season has seen them hampered by injuries to the likes of Christian McCaffrey, Dre Greenlaw and Javon Hargrave, and head coach Kyle Shanahan was handed another headache on Thursday as running back Jordan Mason was forced off with a shoulder issue.
Asked for an update on Mason's condition after the game, Shanahan said: "He thought he was going to be alright.
"He went back in, and it just hurt him too much, so he went out. We'll find out more tomorrow."
San Francisco's victory came at a crucial time as they are involved in the matchup of the season so far in Week 7, when they face the Kansas City Chiefs in a repeat of February's Super Bowl LVIII clash.
Offensive tackle Trent Williams said of that game: "It's not like we can get payback for losing in the Super Bowl. That ship has sailed.
"Obviously, we know what type of team that is, one of the best teams in the league... All-Star quarterback, great coach.
"We're going to take these three days off and regroup and try to put a complete game together."
Purdy throws three touchdowns to lead 49ers past Seahawks
Brock Purdy threw for 255 yards and three touchdowns, and the San Francisco 49ers never trailed in a 36-24 victory over the Seattle Seahawks on Thursday night.
Deebo Samuel had a 76-yard catch-and-run touchdown and finished with three catches for 102 yards for the defending NFC champions (3-3), who moved into a tie with Seattle (3-3) for first place in the NFC West after an uneven start to the season.
George Kittle added five receptions for 58 yards and two scores for the 49ers, who beat the Seahawks for a sixth straight time. Kyle Juszczyk added a late TD run for the 49ers, and he and Kittle both celebrated their scores by leaping into the stands to embrace their wives, who were sitting together in the first row.
Matthew Wright, who joined San Francisco earlier this week to replace injured kicker Jake Moody, had a trio of first-half-field goals from 25, 41 and 35 yards.
Geno Smith passed for 312 yards and a touchdown but was intercepted twice, and the Seahawks lost their third straight after a 3-0 start under new coach Mike Macdonald.
Purdy throws 3 touchdowns to lead 49ers past Seahawks
Brock Purdy threw for 255 yards and three touchdowns, and the San Francisco 49ers never trailed in a 36-24 victory over the Seattle Seahawks on Thursday night.
Deebo Samuel had a 76-yard catch-and-run touchdown and finished with three catches for 102 yards for the defending NFC champions (3-3), who moved into a tie with Seattle (3-3) for first place in the NFC West after an uneven start to the season.
George Kittle added five receptions for 58 yards and two scores for the 49ers, who beat the Seahawks for a sixth straight time. Kyle Juszczyk added a late TD run for the 49ers, and he and Kittle both celebrated their scores by leaping into the stands to embrace their wives, who were sitting together in the first row.
Matthew Wright, who joined San Francisco earlier this week to replace injured kicker Jake Moody, had a trio of first half-field goals from 25, 41 and 35 yards.
Geno Smith passed for 312 yards and a touchdown but was intercepted twice, and the Seahawks lost their third straight after a 3-0 start under new coach Mike Macdonald.
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