Aaron Rodgers lost a fifth straight game for just the second time in his NFL career as the Green Bay Packers were upset again by NFC North rivals the Detroit Lions.
The Packers are enduring a torrid season and fell to 3-6 with this latest 15-9 defeat on Sunday.
Green Bay had not previously lost five in a row since 2008 – Rodgers' first year as a starter – but there is no sign of their misery ending any time soon.
Rodgers, previously so dominant in division matchups, threw three interceptions in a game for only the fifth time in his career and for the first time against NFC North opponents.
Two of those came with the game still scoreless, giving the lowly Lions a foothold they fought hard to protect.
Detroit had traded T.J. Hockenson within the division to the Minnesota Vikings at the deadline, but that void was filled by a pair of career-first touchdown catches from tight ends.
Shane Zylstra – elevated from the practice squad on Saturday alongside wide receiver brother Brandon – got the Lions on the board with his first catch of the year, while rookie James Mitchell's score at the start of the fourth quarter ultimately proved decisive.
Bills loss leaves AFC East in the balance
The fourth of Rodgers' five successive defeats had come against the Buffalo Bills last week, but Josh Allen was also on the end of a shock loss on Sunday as the New York Jets blew the AFC wide open. Despite two rushing TDs, Allen was every bit as hapless as Rodgers through the air as he threw two interceptions in the Jets' tense 20-17 win.
With the Bills 6-2 and the Jets 6-3, the AFC East is among the year's closest fought divisions, with the Miami Dolphins just about improving to 6-3 by fending off the Chicago Bears 35-32. Justin Fields kept the Bears in touch, throwing three TD passes and rushing for 178 yards – a Super Bowl era record among quarterbacks. His stunning 61-yard TD run was the longest of his career.
Mixon makes hay with Bengals' first five-TD game
There was no late drama in the game between the Cincinnati Bengals and the Carolina Panthers, which was dominated by running back Joe Mixon. He rushed for four TDs and had five total scores – also catching a Joe Burrow pass. It was just the ninth five-plus-TD game of the Super Bowl era – and the first by a Bengal – and set up a 42-21 victory.
Warner hails Niners for 'standing tall' in nervy Seattle win
San Francisco 49ers linebacker Fred Warner hailed the team for standing tall on the road after they held off a Seattle Seahawks fightback for a crucial 36-24 win.
The Niners were in dire need of a victory after blowing double-digit fourth-quarter leads in losses to the Los Angeles Rams and Arizona Cardinals in Weeks 3 and 5.
They made a strong start to Thursday's meeting between two NFC West rivals, assuming a 23-3 lead early in the third quarter, as Brock Purdy threw a 76-yard catch-and-run touchdown to Deebo Samuel and another score to George Kittle.
However, the defending NFC champions let Seattle back in and saw their lead trimmed to six points by the start of the fourth, with the Seahawks reeling off 14 straight points then getting the ball back via a Rasheem Green interception.
However, they held firm and another two touchdowns – a second Purdy-Kittle link-up and a six-yard Kyle Juszczyk rush – ensured they improved to 3-3, level with Seattle.
Asked if doubts began to creep in as the Niners' lead shrunk, three-time All-Pro Warner said: "A thousand percent.
"It sucks, but yes, it was something that felt familiar for sure. We could go one of two ways right there.
"We could stand tall in a hostile environment and get the game that we got to get or we could settle for exactly how we've been playing the last couple losses."
The 49ers' season has seen them hampered by injuries to the likes of Christian McCaffrey, Dre Greenlaw and Javon Hargrave, and head coach Kyle Shanahan was handed another headache on Thursday as running back Jordan Mason was forced off with a shoulder issue.
Asked for an update on Mason's condition after the game, Shanahan said: "He thought he was going to be alright.
"He went back in, and it just hurt him too much, so he went out. We'll find out more tomorrow."
San Francisco's victory came at a crucial time as they are involved in the matchup of the season so far in Week 7, when they face the Kansas City Chiefs in a repeat of February's Super Bowl LVIII clash.
Offensive tackle Trent Williams said of that game: "It's not like we can get payback for losing in the Super Bowl. That ship has sailed.
"Obviously, we know what type of team that is, one of the best teams in the league... All-Star quarterback, great coach.
"We're going to take these three days off and regroup and try to put a complete game together."
Purdy throws three touchdowns to lead 49ers past Seahawks
Brock Purdy threw for 255 yards and three touchdowns, and the San Francisco 49ers never trailed in a 36-24 victory over the Seattle Seahawks on Thursday night.
Deebo Samuel had a 76-yard catch-and-run touchdown and finished with three catches for 102 yards for the defending NFC champions (3-3), who moved into a tie with Seattle (3-3) for first place in the NFC West after an uneven start to the season.
George Kittle added five receptions for 58 yards and two scores for the 49ers, who beat the Seahawks for a sixth straight time. Kyle Juszczyk added a late TD run for the 49ers, and he and Kittle both celebrated their scores by leaping into the stands to embrace their wives, who were sitting together in the first row.
Matthew Wright, who joined San Francisco earlier this week to replace injured kicker Jake Moody, had a trio of first-half-field goals from 25, 41 and 35 yards.
Geno Smith passed for 312 yards and a touchdown but was intercepted twice, and the Seahawks lost their third straight after a 3-0 start under new coach Mike Macdonald.
Purdy throws 3 touchdowns to lead 49ers past Seahawks
Brock Purdy threw for 255 yards and three touchdowns, and the San Francisco 49ers never trailed in a 36-24 victory over the Seattle Seahawks on Thursday night.
Deebo Samuel had a 76-yard catch-and-run touchdown and finished with three catches for 102 yards for the defending NFC champions (3-3), who moved into a tie with Seattle (3-3) for first place in the NFC West after an uneven start to the season.
George Kittle added five receptions for 58 yards and two scores for the 49ers, who beat the Seahawks for a sixth straight time. Kyle Juszczyk added a late TD run for the 49ers, and he and Kittle both celebrated their scores by leaping into the stands to embrace their wives, who were sitting together in the first row.
Matthew Wright, who joined San Francisco earlier this week to replace injured kicker Jake Moody, had a trio of first half-field goals from 25, 41 and 35 yards.
Geno Smith passed for 312 yards and a touchdown but was intercepted twice, and the Seahawks lost their third straight after a 3-0 start under new coach Mike Macdonald.
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