Patrick Mahomes was left stunned after the Kansas City Chiefs fell to a 24-20 home loss against the Buffalo Bills on Sunday.
With time running out, Bills quarterback Josh Allen led his team on a brilliant 76-yard, 13-play drive, ending in a touchdown pass to tight-end Dawson Knox to give the visitors the lead with 1:04 left in the fourth quarter.
But Bills' hearts were in mouths as they feared a situation similar to January's Divisional-Round game, where Allen's touchdown pass to Gabe Davis with 13 seconds left on the clock looked to have sent Buffalo to the AFC Championship, only for Mahomes to set up a match-tying field goal before the Chiefs won in overtime.
However, Mahomes was not able to conjure up the same magic this time, throwing a crucial interception to cornerback Taron Johnson with 41 seconds remaining to seal victory for the Bills.
Mahomes was frustrated after the loss, telling reporters: "Every time I get the ball, no matter what the situation, is I expect to find a way to win.
"That's what this whole offense [and] this team expects. I always expect to win until there's literally no time so any time you lose definitely hurts. You lose a game, especially at home, it's never a good feeling.
"I thought we played some good football, we just made too many mistakes at the end of the day and when you make mistakes against another great football team you lose football games. It'll be good to learn from, but right now it stinks for sure."
Mahomes' killer pick to Johnson came as he tried to elude pressure from Bills' star edge rusher Von Miller, who signed a six-year $120million deal with Buffalo in March after winning the Super Bowl with the Los Angeles Rams the month prior.
Miller finished Sunday's game with two sacks, and Mahomes acknowledged his impact on the Bills' defense, saying: "Von [Miller] obviously made plays.
"He's a Hall of Famer for a reason so he's going to make plays here and there. He's a great player so any time you add a great player like that, a Hall-of-Fame player, you have to account for him on every single play."
With the Chiefs and Bills both starting the season impressively, there is a decent chance the teams meet again in this season's AFC playoffs.
But Mahomes was keen to divert his team's focus to next weekend's clash with the San Francisco 49ers, who the Chiefs beat in the 2020 Super Bowl to give Mahomes his first Vince Lombardi trophy.
When asked whether he expects to play the Bills again in the postseason, the 27-year-old replied: "You can definitely see it because they're going to be a team that's going to be in the playoffs or competing for the playoffs.
"But you can't look ahead, and I think that's the biggest thing to me. I think I learned that last year in the AFC Championship game. Sometimes if you start looking ahead that's when you get beat and we don't want to look ahead.
"We have a great football team we're playing [the 49ers] and [then] we're going into the bye [week], and then we're going to have a schedule of a lot of division opponents coming up.
"So we want to make sure we focus on this next week - how can we get better to go out there, to go out there execute and try to find a way to win against a great football team at their home."