Primoz Roglic will set out on a mission to create cycling history as the Slovenian gets his Vuelta a Espana campaign under way on Friday.
The 77th edition of the Grand Tour starts in Utrecht, with the opening three stages taking place across the Netherlands before the caravan transfers to Spain.
It is only the fourth time that the Vuelta has started outside of Spain, after doing so in Portugal in 1997, the Netherlands in 2009 and France in 2017.
Spanish riders have won 32 of the previous 76 editions, but not since 2014 has a Spaniard triumphed, when Alberto Contador tasted glory.
It is the longest wait for a Spaniard champion in the race's history, and in the last three years, it is Roglic who has dominated.
Meanwhile, Alejandro Valverde, the 2009 champion, will bid goodbye to his home Grand Tour.
Roglic's shot at history
Roglic won his first Vuelta title in 2019 and successfully defended in 2020, despite his heartbreaking defeat to Tadej Pogacar at that year's Tour de France.
He crashed out of Le Tour in 2021 but bounced back in style, winning Olympic gold in Tokyo before clinching a third-straight Vuelta triumph to match the feats of Tony Rominger (1992 to 1994) and Roberto Heras (2003 to 2005).
Now, Roglic has history in his sights. Only Heras has won the Vuelta on four occasions, but no rider has ever won it over four successive years.
The 32-year-old Roglic's Tour de France again ended early this year, as he watched team-mate Jonas Vingegaard storm to success and set up a rivalry with Roglic's compatriot Pogacar that should enthral for years to come; but at the Vuelta, Roglic is Jumbo-Visma's main man.
Roglic has won the Vuelta in all of his three appearances, reaching nine stage wins in this period, more than any other rider (Fabio Jakobsen is the next best, with five to his name). He also claimed the points ranking in both 2019 and 2020, and could equal Erik Zabel (three) as joint-second on the all-time list for that classification, behind Sean Kelly, Valverde and Laurent Jalabert (four each).
"Of course the record gives me more motivation, it's special," said Roglic in a press conference on Thursday. "We're going to fight for that."
There are some concerns over his fitness after the injury he suffered at Le Tour, however.
Roglic said: "At certain moments I still feel some pain, but it is already much better than before. We'll see. If I get to the start here, it means I'm ready too. But I'll have to wait and see in the coming days and weeks to find out how it really goes."
Roglic could also feasibly set a record for the most stages wearing the red leader's jersey. He is currently level with Herras on 36, 12 behind Alex Zulle's haul of 48.
A last dance for Vuelta veterans?
Valverde, of Movistar, will be making his 16th Vuelta appearance. The 42-year-old has achieved more podium finishes in the general classification than any other rider, having done so on seven occasions, including his 2009 success.
If he completes the race, Valverde, who has won 12 individual stages at La Vuelta, will equal Federico Etxabe, Chente Garcia Acosta and Inigo Cuesta as riders who have finished the most times (14).
"To win a stage would be incredible," Valverde said on Thursday. "I don't believe I will be at the same level as the best during 21 days, but we do have a team-mate who can be among the top three or perhaps even win. What I see for myself is that I will try to win a stage."
Chris Froome, meanwhile, is a two-time Vuelta champion who is out to prove himself once more.
The seven-time Grand Tour winner has been struggling with COVID-19 in the build-up this time but is set to make his eighth appearance in the race, having finished on the podium four times, taking the 2011 and 2017 titles.
The first of those victories was only awarded to Froome in 2019 after original race winner Juan Jose Cobo was disqualified for a doping offence.
In a stellar career, Froome has become the first British rider to win all three of the biggest races in cycling.
Milan 3-1 Hellas Verona: Leao double condemns visitors to Serie A relegation play-off
Milan signed off the Serie A season with a 3-1 victory as Rafael Leao's double condemned Hellas Verona to a relegation play-off with Spezia.
The Rossoneri wrapped up a frustrating campaign on a winning note at San Siro, with a late Leao brace enough to seal three points.
Milan had already secured Champions League football for another term but struggled at times against the visitors, who cancelled out Olivier Giroud's first-half penalty through Marco Faraoni's 72nd-minute strike.
Yet Leao struck in the 85th minute and again seven minutes later, leaving Verona to face a relegation decider with Spezia, who succumbed to a late 2-1 loss at Roma.
Udinese 0-1 Juventus: Chiesa strikes but Bianconeri miss out on top-six Serie A finish
Juventus missed the chance to finish sixth in Serie A despite Federico Chiesa's strike sealing a 1-0 victory over Udinese at Dacia Arena.
After Paulo Dybala's late penalty helped Roma to a 2-1 victory over Spezia, Massimiliano Allegri's side were unable to leapfrog the Giallorossi and were forced to settle for a seventh-place finish in the league.
Chiesa's second-half strike was the difference for Juve, who were deducted 10 points for violating financial rules earlier in a rollercoaster campaign, but they suffered their lowest finish in Serie A for 12 years.
Meanwhile, Udinese finished 12th in Serie A following their 10th defeat in 12 meetings with the Old Lady.
Udinese had lost their last three but went close after just four minutes when Beto somehow headed Florian Thauvin's cross over from inside the six-yard box.
Federico Chiesa’s deflected effort hit the side-netting before Juve saw a headed opportunity go begging as Leonardo Bonucci nodded against the crossbar from seven yards out following Arkadiusz Milik's flick-on.
Chiesa continued to cause Udinese problems down the left flank, yet the sides headed into half-time goalless after a profligate showing from both teams.
Juve squandered a great chance to break the deadlock just after the hour mark, Adrien Rabiot firing wide despite being found by Milik in acres of space inside the box.
But the visitors eventually opened the scoring in the 68th minute, Chiesa receiving the ball from Manuel Locatelli before bending a brilliant shot into the bottom-right corner.
Locatelli and Angel Di Maria went close to extending the advantage and though the single goal was enough, former Juve forward Dybala was to snatch sixth place for Roma from under his old club's nose.
Celta Vigo 2-1 Barcelona: Veiga double secures safety as Celestes stun champions
Gabri Veiga scored twice as Celta Vigo clinched survival with a surprise 2-1 win over champions Barcelona on a dramatic final day of the season in LaLiga.
Starting the game in 17th, Celta knew a victory would preserve their top-flight status, and Carlos Carvalhal's men took charge as Veiga struck either side of the break.
The 21-year-old drilled into the bottom-left corner to spark wild scenes at the Balaidos shortly before half-time, then saw a fortuitous 65th-minute cross sail in off the far post.
Celta clung on after Barca substitute Ansu Fati nodded home, clinching a 13th-placed finish as Real Valladolid went down, while Barca ended the campaign 10 points clear of runners-up Real Madrid.
Barca thought they had an 11th-minute lead when Franck Kessie latched onto a rebound to beat Ivan Villar, only for a VAR review to show the midfielder was offside.
Oscar Rodriguez skewed a first-time shot just wide as Celta went close, while Robert Lewandowski saw a curling effort clip the outside of Villar's left post.
The offside flag thwarted Rodriguez as he capitalised on Marc-Andre ter Stegen's error to flick home, but Celta did go ahead on the stroke of half-time when Veiga raced onto Haris Seferovic's pass to finish across goal.
With Barca struggling for momentum, Veiga put Celta 2-0 up when his mishit cross from the right swerved over substitute goalkeeper Inaki Pena, clipping the woodwork before nestling in the back of the net.
Fati ensured a nervous finish by heading in Ousmane Dembele's cross 11 minutes from time, but Celta clung on to ensure another season of top-flight football.
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