Dan Biggar and Alun Wyn Jones are in line to claim their 100th and 150th Wales caps when Wayne Pivac's side host Italy in the Six Nations on Saturday.
Wales sit fifth in the table after falling to a third defeat in four outings following a 13-9 loss to France last Friday, with their only win coming against Scotland on February 12.
However, Pivac's team will be boosted by the return of Jones, who comes back into the starting side for the first time since suffering a shoulder injury against New Zealand at the end of October.
Biggar retains the captaincy despite 36-year-old Jones returning, with the former set to become the seventh Welshman to win 100 caps for his country.
Coach Pivac, who has made seven changes to his team that lost against table-toppers France, believes the pair deserve to share their milestone appearances together.
"We've said with other players reaching 100 appearances what an achievement that is and for Dan I know he's been looking forward to this moment for a long time," Pivac told reporters on Tuesday.
"For him to achieve it with Al, who is also getting the milestone of 150 caps – which no other player has ever done – I think it's fitting for those two to share the day.
"They've played a lot of rugby together and have a healthy respect for each other. They've given so much for the game in Wales."
Gareth Davies is in line for his first start in this year's Six Nations, with Johnny McNicholl, Louis Rees-Zammit and Willis Halaholo all recalled in the backline as well.
Meanwhile, Dewi Lake, Dillon Lewis and last year's Lions captain Jones are the forwards who come in, with Ryan Elias, Alex Cuthbert, Jonathan Davies, Tomas Francis, Liam Williams, Tomos Williams and Will Rowlands dropping out of the starting side.
On the changes, Pivac added: "We've made a few changes this week. With one game to go there are some players we need to see out there and put them in the matchday 23.
"We've certainly selected a side which we think can get the job done. Clearly that's what we're here for. There's an opportunity to move up that table, so we think this is an exciting team and one we're looking forward to seeing out there.
"Italy are a side that's improving, they've had some bad luck here and there and with a new coach transitioning we know it takes a bit of time.
"But we know they've got some very good rugby players and as you saw against Scotland they troubled them in that second half and for long periods of the first. So we're going to have to be on our game and we're very much looking forward to playing at home again this weekend.
"We had a good result against Scotland, gave the fans something to cheer about and came very close against an in-form France. Obviously disappointed we couldn't get across the line for our fans there and we hope we can do that this weekend and finish on a high."
Wales team: Johnny McNicholl, Louis Rees-Zammit, Owen Watkin, Uilisi Halaholo, Josh Adams, Dan Biggar, Gareth Davies; Gareth Thomas, Dewi Lake, Dillon Lewis, Adam Beard, Alun Wyn Jones, Seb Davies, Josh Navidi, Taulupe Faletau.
Replacements: Bradley Roberts, Wyn Jones, Leon Brown, Will Rowlands, Ross Moriarty, Kieran Hardy, Callum Sheedy, Nick Tompkins.
Wallabies will get things right before Lions tour, promises Rugby Australia chief
Rugby Australia chief executive Phil Waugh is confident the Wallabies will be ready to compete with the British and Irish Lions next year, despite suffering the heaviest defeat in their Test history last time out.
Australia were crushed 67-27 by Argentina in the Rugby Championship last time out, their third defeat in four games in this year's tournament.
They were also dumped out of last year's Rugby World Cup in the pool stage following losses to Fiji and Wales, and they are down to ninth in the World Rugby Rankings.
The British and Irish Lions will face Australia in three Tests when they tour down under between June and August next year, with many fearing Joe Schmidt's team will be blown away.
Waugh, however, says there is plenty of time for the Wallabies to get things right before then, telling the Sydney Morning Herald: "You can see the progress is there.
"It is not nearly where we need it to be, but if we keep progressing at the speed with which we have moved things in the last six months, then there is plenty of time.
"It is a team that is, and I hate using the word 're-building', but it is a team that is re-setting, and it takes experience in big moments to get better.
"Obviously, the enormity of the scoreline in that second half was disappointing.
"But there is context that is important... we are not the most experienced team in world rugby, and we are building that experience."
Australia conclude their Rugby Championship campaign with two fixtures against New Zealand before the end of September, then face England, Wales, Scotland and Ireland in their Autumn International Tests in November.
Frattesi 'deserves trust' from Inter after Italy form, says former Azzurri midfielder Tardelli
Davide Frattesi "deserves trust" from Inter following his impressive form with Italy, according to former Azzurri midfielder Marco Tardelli.
Frattesi was on target in Italy's victories over France and Israel during the international break, as Luciano Spalletti's side made a perfect start to Group A2 in the Nations League.
The 25-year-old has now scored an impressive seven goals - the most of any player during the Spalletti era - in just 21 appearances since making his senior international debut two years ago.
However, he has not featured as frequently this season for Inter, who he joined from Sassuolo on a permanent basis after his initial loan spell last term, with all three of his appearances coming from the bench.
Frattesi faces competition from the established central midfield trio of Nicolo Barella, Hakan Calhanoglu and Henrikh Mkhitaryan.
But 1982 World Cup winner Tardelli, who expects him to be "a starter" alongside Barella for Italy in the coming years, believes he deserves more opportunities with the Nerazzurri.
"Frattesi needs trust from Inter. There aren't many players like him," the former Inter boss told Gazzetta.
"Inzaghi has many strong players. The trio in midfield - Barella, Calhanoglu, and Mkhitaryan - is a certainty. I can't tell Simone who to play, but everyone's seeing what Frattesi is doing. He makes a difference, and he deserves trust.
"He's one of the new midfielders who knows how to be in the right place at the right time. The goal he scored with his chest against Israel proves it. He's always there. He knows how to make late runs and play vertically.
"He attacks, defends and scores crucial goals. He was decisive last season, despite not being a starter. He has great courage. A player like him gives any coach multiple options, and Inzaghi knows this well."
De Bruyne launches scathing review after Belgium loss
Kevin De Bruyne hit out at Belgium following their 2-0 defeat to France on Monday, claiming they have "to be better in every way".
Ousmane Dembele ran the show for Les Bleus in their second Nations League match, scoring France's second after Randal Kolo Muani had opened the scoring in the first half.
Belgium, meanwhile, managed just nine shots in the game, with just two of those coming in a lacklustre first-half performance.
While De Bruyne refused to give any details of his half-time team talk, he did not hold back his criticism of the team.
"I can't say here what went wrong. I already did that to the team at half-time," he said.
"I cannot repeat that in the media, but it has to be better in every way. If the standard we want to reach is the best, but we're no longer good enough to get to that level, then you have to give everything.
"If you don't even do that, it's over.
"I can accept that we're not as good as in 2018 [when they reached the World Cup semi-finals].
"I was the first to see that, but other things are unacceptable. I'm not going to say what."
Belgium sit third in Group A2 after two games, level with France on three points.
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