Wales need a victory against France in Paris to reclaim the Six Nations crown, and complete a Grand Slam in the process.
Wayne Pivac's team have enjoyed a sensational turnaround in fortunes this year and last week's 48-7 thrashing of lowly Italy made it four wins from four.
With France subsequently losing to England at Twickenham, Wales will wrap up the title with a win on Saturday, while even a losing bonus point could be enough, though that may still leave the door open for Les Bleus to snatch glory should they win their postponed fixture against Scotland.
England are well out of the race, but their captain Owen Farrell is eyeing up a points landmark when the 2020 champions take on Ireland in Dublin.
Scotland, meanwhile, round off what will ultimately go down as a frustrating campaign against Italy.
We use Opta data to preview the round-five, Super Saturday encounters.
SCOTLAND V ITALY
FORM
Scotland have won their last five Six Nations games against Italy – the previous 10 clashes between the sides had seen them share five wins each.
Italy have lost 52 of 54 away games in the Six Nations, with their only two victories on the road coming in Scotland in 2007 and 2015.
That victory at Murrayfield in 2015 was Italy's last in the competition. Their losing streak now stands at 31 games, and they will pick up the wooden spoon for the 16th time in Six Nations history.
ONES TO WATCH
Scotland have the best tackle success rate (92 per cent) of any side in this year's competition. Hamish Watson leads the way in that regard, completing all 44 of his attempted tackles – he has made 133 consecutive tackles in the tournament without missing one, the second-longest such run in Six Nations history, behind Lionel Nallet's 154 for France.
Italy's Sebastian Negri has made 127 post-contact metres in the 2021 Six Nations, the most of any forward in the championship.
IRELAND V ENGLAND
FORM
England have won their last two meetings with Ireland in the Six Nations and could win three in a row against them for only the second time, after doing so between 2012 and 2014.
Ireland lost to France in their last home game, only once before have they suffered defeat in back-to-back home games in the Six Nations – in 2010 versus Scotland at Croke Park and 2011 versus France at the Aviva Stadium.
Jones' England have won their last four Tests against Ireland, preventing them from scoring any first-half points in their last two meetings and scoring an average of 4.3 tries per game in that run.
ONES TO WATCH
CJ Stander announced his retirement this week, with the 31-year-old set to hang up his boots at the end of the season. This will be his final appearance for Ireland, having won his 50th cap in the 27-24 win over Scotland in round four.
Owen Farrell, son of Ireland coach Andy, is the top scorer in the Six Nations this year (44) and is just six points away from 500 in the championship. Only Ronan O'Gara (557) has reached that milestone exclusively in the Six Nations (since 2000).
FRANCE V WALES
FORM
Wales are bidding to win a sixth Six Nations title (since 2000), only England (seven) have won the championship more often. If they win this match it would be their fifth
Grand Slam – no other side has more than three.
Recent history is on Wales' side heading to the Stade de France. They have won three of their last four away games against Les Bleus in the Six Nations (L1), triumphing in their last trip to Paris (24-19 in 2019) despite trailing by 16 points at half-time – the biggest comeback for a team in the competition.
Indeed, pre-tournament favourites France have won only two of their last nine Six Nations games against Wales (L7) after winning nine of the previous 12 (L3).
ONES TO WATCH
Antoine Dupont already has four try assists in this Six Nations, only five players have ever recorded more in an edition of the championship, with Frederic Michalak
(seven in 2006) the only Frenchman to do so.
Louis Rees-Zammit is the joint top try scorer in the 2021 Six Nations (four, level with England's Anthony Watson). Shane Williams (six in 2008) is the only Welsh player to score more than four in an edition of the tournament.
“We have the manpower within the dressing room”- Sammy confident Windies can overcome 0-2 deficit against England
West Indies white ball head coach Daren Sammy says there’s still optimism in his camp that they can overcome the 0-2 deficit they currently face in their five-game T20I series against England.
The hosts lost the first two game of the series at the Kensington Oval in Barbados on Saturday and Sunday, with the rest of the series now shifting to the Daren Sammy Stadium in St. Lucia beginning with the third T20I on Thursday.
“Most definitely, especially here in St. Lucia,” Sammy said in a pre-match interview on Tuesday regarding his team’s optimism ahead of Thursday’s must-win game and the rest of the series.
“Yes, England have played better cricket than us in these first two games but I’ve rallied St. Lucia to come out and be the 12th man that we need here. We just haven’t played the brand of cricket that has allowed us to win and it’s something that we’re going to address but we have the manpower within that dressing room to win on Thursday and take it one game at a time,” he added.
The West Indies will be without two key players for the rest of the series in Andre Russell and Shamar Joseph.
Russell suffered an ankle injury in the first T20I on Saturday and has been ruled out for the rest of the series while Joseph has left the squad to prepare for the upcoming Test series against Bangladesh starting on November 22 in Antigua.
Replacing the pair are all-rounder Shamar Springer and spearhead Alzarri Joseph, returning to the squad after serving a two-game suspension.
“It’s always a blow to replace somebody like Andre Russell. We have young Shamar Springer who made his debut in Sri Lanka to replace him. He’s a really exciting prospect,” Sammy said.
“Shamar will go in and get ready for the Test series and Alzarri is back from his suspension. We’re looking forward to welcoming him and the experience he brings to the squad. Yes, we lose two key guys but we get two guys who are capable of doing the job for the team as well,” he added.
Harwood-Bellis 'didn't quite believe' first senior England call-up
Taylor Harwood-Bellis revealed he was in a state of disbelief when he was told about his first call-up to the England senior team last week.
Harwood-Bellis, along with Newcastle's Lewis Hall, received their maiden Three Lions call-ups in Lee Carsley's final squad as interim head coach.
The Southampton defender has impressed under Russell Martin this season, featuring in all of their Premier League fixtures so far this season.
Harwood-Bellis has won more aerial duels (13) for the Saints in the top-flight this term, with only Jan Bednarek (888) completing more passes than the 22-year-old (684).
He is also someone well known to the interim boss from his time in charge of England's Under-21's side, with his 21 appearances more than any other player during Carsley's tenure in the current Three Lions squad.
"Lee Carsley rang me in the morning and said, 'you'll be with us, with the seniors'. I didn't quite believe it at first," he told a press conference.
"My partner was next to me and I phoned my dad, who was very proud. He loves when I play for England, even the younger age groups.
"One of the first people to message me was Aaron Ramsdale. I was happy to see his name as he's one of my mates at the club."
Unfortunately for Harwood-Bellis, Ramsdale has since pulled out of the squad with a finger injury and has been replaced by Burnley's James Trafford.
England travel to Athens to take on Group B2 leaders Greece on Thursday before returning to Wembley three days later as they square off against the Republic of Ireland.
With a number of first-team regulars out through injury, Harwood-Bellis has the opportunity to become the first Saints player to represent England since Kyle Walker-Peters did so back in 2022.
The defender understood the potential ramifications of performing well for the Three Lions during this international break, with Thomas Tuchel taking over in the new year.
"It will be a big motivation for all of the lads, knowing that there's a new manager coming in and wanting to keep your spot," he said.
"That's something that especially the younger lads will be pushing towards.
"It's going to be difficult because of the quality and experience in some of the lads that aren't here is massive.
"It'll be difficult, but it'll be something that I'll focus on week in and week out for Southampton and if I get minutes here."
Springboks aiming to have 'two best teams in the world', says Esterhuizen
South Africa centre Andre Esterhuizen said that the Springboks are aiming to have "the two best teams in the world" ahead of their Autumn Nations Series clash against England.
The world champions were pushed all the way by Scotland in their narrow victory at Murrayfield on Sunday, though head coach Rassie Erasmus opted to rotate some key starting positions.
South Africa captain Siya Kolisi and flanker Pieter-Steph du Toit started on the bench, with the changes a common theme during Erasmus' seven-year tenure.
Their opening Autumn Nations Series victory also put them back on top of the world rankings after Ireland's first defeat in 19 home games by New Zealand on Friday.
"One of the good things is that everyone is getting game time now," Esterhuizen told the BBC's Rugby Union Weekly podcast.
"It is also about looking forward, you've got to be able to spare all the guys for the next World Cup and build experience into it.
"The aim is to have the two best teams in the world, all in one squad.
"We want to make it second nature for people slotting in, so if someone steps in, they can just slot in and play the same if not better than the other player."
South Africa next face England, who are yet to pick up a win this autumn, at Twickenham on Saturday.
Steve Borthwick's side suffered a narrow two-point defeat by New Zealand, before conceding an injury-time winning try to Australia on Saturday.
England have now lost each of their last four Test matches, their longest such run since losing five straight games in 2018, but Esterhuizen's former Harlequins team-mate Marcus Smith has been impressive for the Red Roses.
"It's a great space, I obviously love to play there," Esterhuizen added. "It will be great to be running at Marcus, not run off him.
"It's going to be a great match, England have played well in the last few games, it's unfortunate that it hasn't been the results that they want. I think it's going to be a big one."
The Springboks have won three of their last four matches against England (L1), including each of their last two. Three of the last five games between England and South Africa have been decided by single-point margins.
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