Jamison Gibson-Park retained his place in the Ireland side, while Sean Maitland and Jamie Ritchie will return for Scotland in Sunday's Six Nations encounter at Murrayfield.
Gibson-Park started the loss to France and victory over Italy, with Conor Murray ruled out, and the scrum-half did enough to retain the number nine jersey.
Murray is back on the bench along with Jordan Larmour, who is replaced on the wing by the experienced Keith Earls.
Prop Cian Healy comes in at loosehead at the expense of Dave Kilcoyne, who is named among the replacements as Andy Farrell's men attempt to make it two wins from four in the tournament.
Gregor Townsend has made four alterations to his line-up for Scotland's first match in a month after their clash with France was postponed due to a coronavirus outbreak in Les Bleus' camp.
Wing Maitland and flanker Ritchie return from injury, replacing Darcy Graham and Blade Thomson respectively.
Zander Fagerson's suspension gives prop WP Nel the chance to start, Sam Johnson makes his first appearance of the tournament in place of James Lang.
Grant Gilchrist and Nick Haining will be ready to feature in the 2021 Six Nations for the first time from the bench.
Ireland: Hugo Keenan, Keith Earls, Garry Ringrose, Robbie Henshaw, James Lowe, Johnny Sexton, Jamison Gibson-Park; Cian Healy, Rob Herring, Tadhg Furong, Iain Henderson, James Ryan, Tadhg Beirne, Will Connors, CJ Stander.
Replacements: Ronan Kelleher, Dave Kilcoyne, Andrew Porter, Ryan Baird, Jack Conan, Conor Murray, Billy Burns, Jordan Larmour.
Scotland: Stuart Hogg, Sean Maitland, Chris Harris, Sam Johnson, Duhan van der Merwe, Finn Russell, Ali Price; Rory Sutherland, George Turner, WP Nel, Scott Cummings, Jonny Gray, Jamie Ritchie. Hamish Watson, Matt Fagerson.
Replacements: David Cherry, Jamie Bhatti, Simon Berghan, Grant Gilchrist, Nick Haining, Scott Steele, Huw Jones, Darcy Graham.
'World-class' Scotland will provide Wallabies' sternest test – Skelton
Australia will face their sternest test to date when they continue their autumn tour against a "world-class" Scotland team at Murrayfield on Sunday.
That is the view of forward Will Skelton, who believes the Wallabies' victories in England and Wales have brought a new energy and confidence to their camp.
Having crashed out in the pool stage at last year's World Cup in France before finishing last in the Rugby Championship, Australia have looked a team reborn in recent weeks.
A first victory at Twickenham since 2015 and a 52-20 rout of Wales – their biggest-ever away win in matches between the teams – have made it an excellent tour to date for Joe Schmidt's side.
But La Rochelle lock Skelton feels their toughest assignment is to come this week, saying: "We've won two games, we're very aware of that.
"The Test against Scotland is going to be the hardest one yet. We're excited about this weekend and we're looking forward to ripping into it.
"Physically they're up there with the top five in the world. I think set-piece wise they're really strong.
"You've got a guy like Finn Russell who's a maestro at the back there. I think it's going be a close one and we'll be up for it.
"There's some class players in the Scottish team and, when they're at it they're world-class, so we're going to have to be on top of our game."
Wales must 'show courage and front up' against South Africa, says Gatland
Warren Gatland has urged Wales to "show real courage and front up" in their final Autumn Nations clash against South Africa.
Gatland's side bring the curtain down on a disappointing year when they welcome the reigning world champions to the Principality Stadium on Saturday.
Wales have lost an unprecedented 11 straight Tests, and could go an entire calendar year without tasting success for the first time since 1937.
Gatland has made four changes from last weekend's 52-20 defeat to Australia, with Sam Costelow, Rio Dyer, Christ Tshiunza and Taine Plumtree all coming into the starting XV.
Gareth Anscombe, Aaron Wainwright and Cameron Winnett drop out of the squad, while Adam Beard misses out through injury.
And Gatland wants his players to demonstrate fighting spirit against the Springboks.
"Last week's result hurts, and we are just as disappointed by it as the fans," he told reporters during his pre-match press conference.
"Our focus now is on training and preparing well for our final game of this Autumn Nations Series.
"There were good elements that we can definitely build on going into Saturday, but we have to improve our accuracy.
"We know what a quality side South Africa are and the physicality they bring. This week, we need to show real courage and front up against the world champions."
'Playing for England is the Mecca' according to Itoje amid global breakaway talk
Maro Itoje has reaffirmed his commitment to England amid talks of a proposed global breakaway league.
Steve Borthwick’s side are looking to end their five-match losing run when they face Japan in their final match of the autumn series on Sunday.
But there is fear that Borthwick could lose many of his players to the new league that reportedly are offering 40 £1m-a-season contracts for marquee players and more periods of rests for the players.
The Rugby Football Union (RFU) only select players for the national team from English clubs, meaning any player joining the breakaway league would jeopardise their Test career.
But Itoje has insisted that playing for England is the pinnacle for him and his teammates.
"I don't really know any of the details of it as yet, but wearing this rose is extremely important to me and my teammates," said Itoje.
"Playing for England is the Mecca."
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