France resume their bid to win a first Six Nations title since 2010 with a trip to face wounded England at Twickenham, and Wales should made it four wins out of four this weekend.
A coronavirus outbreak in the French camp led to their clash with Scotland being postponed, but they will be back in action against the Red Rose on Saturday a month after beating Ireland.
Wales shattered England's hopes of retaining the title with a 40-24 win at the Principality Stadium and will be expected to stay perfect when they face Italy in Rome, also on Saturday.
Scotland will look to reignite their title challenge when they face Ireland at Murrayfield on Sunday.
We use Opta data to preview the round-four encounters.
ITALY v WALES
FORM
Wales have won their last 15 Tests against Italy, and a 16th would represent their longest ever winning run against a single opponent in Test rugby (they won 15 in a row against France from 1908 to 1927).
A win over England secured Wales' fifth Triple Crown of the Six Nations era, They completed the Grand Slam in each of their previous four Triple Crown-winning campaigns since 2000 (2005, 2008, 2012, 2019).
Italy's losing run in the competition stands at 30 games and they have lost 19 in a row at home, stretching back to a defeat of Ireland eight years ago.
ONES TO WATCH
Azzurri fly-half Paolo Garbisi has made more kicks in play (29) and recorded more kicking metres (1,142m) than any other player in this year's Six Nations.
Josh Adams marked his first match of the tournament by scoring a controversial try against England and the Wales wing will fancy his chances of touching down again in Rome.
ENGLAND v FRANCE
FORM
England have won nine of their 10 home games against France in the Six Nations, including the last seven in a row. Their only defeat came in February 2005, going down 18-17.
France have won seven of their last eight games in the Six Nations and will look for a fourth consecutive victory in the competition this weekend.
Les Bleus have scored the opening try of the game in 15 of their most previous 18 matches in this tournament, including their last eight in a row.
ONES TO WATCH
Wing Anthony Watson will win his 50th cap for England. He has the best average gain per carry rate (10.1 metres) of anyone to make 10 or more carries in the 2021 Six Nations and has also made the most post-contact metres (141).
France lock Paul Willemse has not missed any of his 34 tackles in the Six Nations this year and has made the joint-second most dominant tackles with four, England's Tom Curry (5) the only player to have made more.
SCOTLAND v IRELAND
FORM
Ireland have lost just three of their last 19 games against Scotland in the Six Nations, winning all the rest. Each of the men in green's defeats came by a margin of five points or fewer.
Scotland have lost their last two Test matches at Murrayfield. They have not been beaten in more consecutive games at their traditional home venue since losing four on the bounce between November 2014 and March 2015.
Gregor Townsend's side are the only team to average fewer than 10 missed tackles (8.5) per game in the Six Nations in 2021 and as a result boast the best tackle success rate of 92 per cent.
ONES TO WATCH
Hamish Watson has been an influential performer for Scotland, winning three turnovers and getting through a huge amount of work in the back row.
Ireland back-row Tadhg Beirne has recorded the most ruck arrivals (117) in the tournament, hitting the most rucks of anyone in both attack (87) and defence (30).
Paris Saint-Germain 2-3 Clermont: Messi and Ramos denied winning send-off as visitors fight back
Paris Saint-Germain failed to muster a winning send-off for Lionel Messi and Sergio Ramos as they ended the Ligue 1 season by squandering a two-goal lead in a 3-2 loss against Clermont.
Early goals for the Spaniard and Kylian Mbappe put the champions on top at Parc des Princes, before Johan Gastien, Mehdi Zeffane and Grejohn Kyei completed a stirring comeback from the visitors.
It was a damp last note for ex-LaLiga heroes Messi and Ramos, who leave Paris as two-time league champions but without having won supporters' hearts – with Messi booed ahead of kick-off.
Likewise, it may prove a dour final chapter for coach Christophe Galtier, who is widely tipped to depart despite leading PSG to a record 11th league title.
PSG, who wore shirts adorned with the name of injured team-mate Sergio Rico in the first half, needed VAR to rescue them after Kyei prodded home an early finish.
The hosts promptly seized control, with Ramos netting a farewell header from Vitinha's delivery before Mbappe doubled their lead with an excellent penalty following Alidu Seidu's foul on Achraf Hakimi.
Clermont refused to fold though, with Gastien capitalising on Marco Verratti's mistake to halve the arrears and Zeffane bundling in a leveller either side of Kyei putting a spot-kick wide in a thrilling first half.
Messi, who misfired on his farewell, spurned a chance to finish Mbappe's square ball after the restart before Kyei nosed the visitors in front with a close-range finish.
PSG continued to toil for an equaliser in the closing stages and Messi almost stole a point in the final minute of injury time, only for goalkeeper Mory Diaw to stop his direct free-kick with an acrobatic save.
RB Leipzig 2-0 Eintracht Frankfurt: Nkunku and Szoboszlai strikes ensure DFB-Pokal defence
Christopher Nkunku and Dominik Szoboszlai scored as RB Leipzig retained the DFB-Pokal with a hard-fought 2-0 win over Eintracht Frankfurt in Saturday's final at the Olympiastadion.
Nkunku – playing what will likely be his final game for Leipzig amid suggestions he is set to join Chelsea – beat Kevin Trapp with a deflected effort 71 minutes into a tight encounter in Berlin.
Leipzig were rarely threatened by an uninspired Eintracht team, and Marco Rose's men wrapped up the victory when Nkunku turned provider, teeing up Szoboszlai to score five minutes from time.
That meant Leipzig capped a third-placed Bundesliga finish with a second major trophy in as many seasons, while Oliver Glasner's final game in charge of Eintracht was one to forget.
Timo Werner spurned a glorious chance to put Leipzig ahead after four minutes, side-footing straight at Trapp following a lightning counter-attack.
Randal Kolo Muani hit the side netting from a tight angle and Nkunku forced Tuta into a last-ditch block at the other end, but both sides struggled to break their opponents down in a cagey first half.
Eintracht's threat grew after the interval, but Mario Gotze volleyed straight at Janis Blaswich when presented with their best sight of goal, and Glasner's side were swiftly punished.
There was a huge stroke of fortune as Nkunku struck first, the Frenchman cutting in from the left before seeing his shot take two deflections to beat the unfortunate Trapp.
Eintracht never looked like fighting back from there, though, and Leipzig put the result beyond all doubt when Szoboszlai fired into the bottom-left corner after composed play by Nkunku.
Torino 0-1 Inter: Brozovic strike sees Nerazzurri warm up for Champions League final in style
Inter warmed up for the Champions League final with a 1-0 win over Torino to cap off their Serie A campaign.
The Nerazzurri head to Istanbul to face Manchester City on June 10, but the Coppa Italia winners had league business to attend to on Saturday.
Marcelo Brozovic's excellent strike proved the difference, with substitute goalkeeper Alex Cordaz making a superb save to preserve Inter's lead in the second half.
Inter will face an altogether tougher test in a week's time, but for now, Simone Inzaghi can reflect on a job well done in Serie A.
Romelu Lukaku sparked what had been an insipid first half into life when he crafted space on the edge of Torino's area and saw a low strike deflected just wide.
Stefan de Vrij headed straight at Vanja Milinkovic-Savic from the resulting corner, but Torino's goalkeeper was beaten in the 37th minute.
Given space and time on the edge around 20 yards out, Brozovic punished Torino with a fine left-footed strike that nestled in the bottom-right corner.
Brozovic turned provider shortly after the restart, only for Roberto Gagliardini to head wide from close range.
Ex-Inter forward Yann Karomah almost made an instant impact from the bench when he forced a fine save out of Samir Handanovic, who subsequently received an ovation when he made way for Cordaz in the 65th minute.
Cordaz made a stunning save soon after, reacting brilliantly to parry Antonio Sanabria's effort wide and ensure Inter ended their domestic campaign with a victory.
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