Wales were left to count the cost of their Rugby World Cup victory over Georgia after number eight Taulupe Faletau suffered a broken arm and two other players were also injured.
Faletau, who has won more than 100 caps, will take no further part in the tournament as Wales build towards a quarter-final against probably Argentina or Japan in Marseille next weekend.
Wales head coach Warren Gatland said no decision had yet been made on a replacement for Faletau, although flanker Aaron Wainwright is an option to move across the back-row.
Fly-half Gareth Anscombe, meanwhile, withdrew 45 minutes before kick-off in Nantes following a groin problem suffered during the warm-up.
And full-back Liam Williams was on crutches after Gatland said he took a blow to his knee, but Wales are hopeful he will be fit for the quarter-final, with Wales ending their Pool C campaign as group winners with four successive victories following a 43-19 triumph.
“Toby (Faletau) has broken his arm so he will be out,” Gatland said.
“We are just going to assess Gareth over the next 72 hours. He has pulled his groin very high up.
“Talking to the medics, he has got a bit of power still in his leg which is a positive. It means he has not pulled it off the bone.
“We will probably know in the next 48-72 hours what we need to do with him. Whether we’ve got (time) for him to recover or replace him directly.
“We have got to look at a replacement for Faletau, whether that is directly as a loose-forward replacement or whether we look at another position.
“We’ve got a few sore players, particularly in the backs, after today’s game.
“If you do see Liam Williams on crutches, it is not that he has done anything significantly bad.
“He got a whack on the knee, and the medics, from a comfort perspective, have put him on crutches to save him walking around a bit.
“He has got a knock and probably won’t take a huge part in training in the early part of next week, but hopefully he will be fit for the quarter-final.”
'World-class' Scotland will provide Wallabies' sternest test – Skelton
Australia will face their sternest test to date when they continue their autumn tour against a "world-class" Scotland team at Murrayfield on Sunday.
That is the view of forward Will Skelton, who believes the Wallabies' victories in England and Wales have brought a new energy and confidence to their camp.
Having crashed out in the pool stage at last year's World Cup in France before finishing last in the Rugby Championship, Australia have looked a team reborn in recent weeks.
A first victory at Twickenham since 2015 and a 52-20 rout of Wales – their biggest-ever away win in matches between the teams – have made it an excellent tour to date for Joe Schmidt's side.
But La Rochelle lock Skelton feels their toughest assignment is to come this week, saying: "We've won two games, we're very aware of that.
"The Test against Scotland is going to be the hardest one yet. We're excited about this weekend and we're looking forward to ripping into it.
"Physically they're up there with the top five in the world. I think set-piece wise they're really strong.
"You've got a guy like Finn Russell who's a maestro at the back there. I think it's going be a close one and we'll be up for it.
"There's some class players in the Scottish team and, when they're at it they're world-class, so we're going to have to be on top of our game."
Wales must 'show courage and front up' against South Africa, says Gatland
Warren Gatland has urged Wales to "show real courage and front up" in their final Autumn Nations clash against South Africa.
Gatland's side bring the curtain down on a disappointing year when they welcome the reigning world champions to the Principality Stadium on Saturday.
Wales have lost an unprecedented 11 straight Tests, and could go an entire calendar year without tasting success for the first time since 1937.
Gatland has made four changes from last weekend's 52-20 defeat to Australia, with Sam Costelow, Rio Dyer, Christ Tshiunza and Taine Plumtree all coming into the starting XV.
Gareth Anscombe, Aaron Wainwright and Cameron Winnett drop out of the squad, while Adam Beard misses out through injury.
And Gatland wants his players to demonstrate fighting spirit against the Springboks.
"Last week's result hurts, and we are just as disappointed by it as the fans," he told reporters during his pre-match press conference.
"Our focus now is on training and preparing well for our final game of this Autumn Nations Series.
"There were good elements that we can definitely build on going into Saturday, but we have to improve our accuracy.
"We know what a quality side South Africa are and the physicality they bring. This week, we need to show real courage and front up against the world champions."
Argentina 1-0 Peru: Martinez matches Maradona to snatch qualifying win
Lautaro Martinez equalled Diego Maradona's scoring record for Argentina as his strike secured a 1-0 win over Peru in their CONMEBOL World Cup qualifier.
The Albiceleste bounced back from a shock defeat to Paraguay, with the Inter striker's 55th-minute effort enough to extend their lead at the top of the table to five points.
Argentina started brightly and almost took the lead with their first real opportunity, only for Julian Alvarez's powerful strike to rebound off the outside of the post.
Alexis Mac Allister also came close moments later and rose high to meet Alvarez's cross, though he could only glance his header wide.
Martinez, who netted his 32nd Argentina goal to go joint-fifth in the all-time scoring chart, proved decisive in the second half, acrobatically volleying Lionel Messi's cross into the back of the net.
Lionel Scaloni's side are one place above Uruguay, who they face next. They are on 25 points at the top of the qualifying table, while Peru are rooted to the bottom with just seven.
Data Debrief: Equalling a great
Martinez took 70 appearances to go level with Maradona in the Argentina record books, though he is still a long way off matching Messi's 112-goal tally for his country.
The captain, meanwhile, registered his 58th assist, matching former United States forward Landon Donovan's record for most international assists.
It was a needed win for the hosts, but they had to edge a cagey affair to get it. There were just three shots on target in the whole game, with all three falling to Argentina.
Peru failed to attempt a shot on target for the first time in the CONMEBOL World Cup Qualifiers since facing Argentina in October 2023.
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