Marcus Smith will provide a cutting edge from full-back as England look to give their attack lift off in their World Cup clash with Chile in Lille.
Harlequins fly-half Smith starts in the number 15 jersey for the first time having appeared as a replacement in the previous four Tests, providing a lively counter-attacking threat and extra playmaking option.
On each occasion his arrival acted as a catalyst for England with the ball in hand, particularly in Sunday’s 34-12 victory over Japan.
Owen Farrell returns from suspension to lead the team at fly-half as Steve Borthwick makes 12 changes in personnel for the clash against the lowest-ranked side in Pool D at Stade Pierre-Mauroy on Saturday.
Borthwick has taken the opportunity to rest the bulk of his frontline stars such as stand-in skipper Courtney Lawes, full-back Freddie Steward, hooker Jamie George and centre Manu Tuilagi.
However, George Ford has not been given the weekend off after being picked on the bench, raising the prospect that three players whose primary position is 10 could be on the field at the same time.
At some point in the second half, Farrell and Ford are expected to reprise the playmaking axis that served England well under Eddie Jones until Ford fell out of favour.
Chile are ranked 22nd in the world and offer the scope to experiment as well as rest key personnel with tougher assignments against Samoa on October 7 and a potential quarter-final to come.
Henry Arundell and Max Malins form the wings, while Ollie Lawrence and Elliot Daly are paired together in a classic centre pairing that mixes ball-carrying clout and dynamic running skills.
Only prop Kyle Sinckler and flanker Lewis Ludlam remain from the pack that overran Japan, with hooker Theo Dan and prop Bevan Rodd present in a raw-looking front row.
“One of the many great things about the World Cup is that the tournament provides an excellent opportunity to play against teams that we rarely have a chance to see. It is for that reason that we are particularly looking forward to testing ourselves against Chile on Saturday,” Borthwick said.
“Having watched our next opponent closely, we know that we will have to prepare and play well against a committed Chile team.
“As we head to the next round, it is only right that I once again pay tribute to our excellent supporters who I know will be right behind us in Lille this weekend.”
While there are a host of new faces present, all eyes will be focused on how Smith performs when given more than a cameo role at full-back.
Although unlikely to start in the pressure-cooker matches due to his inexperience in the position, Borthwick appears to have found an important role for one of the most exciting talents in English rugby.
It is also a crucial match for Farrell, who needs minutes on the field after making his most recent appearance against Wales on August 12 when he was sent off for a dangerous tackle on Taine Basham.
Stokes out of first Pakistan Test through injury
England captain Ben Stokes is out of their first Test against Pakistan having failed to recover from a hamstring tear in time.
Stokes suffered the hamstring injury in August playing in The Hundred and has not played since, missing England's three-match series against Sri Lanka last month.
England said last week that the 33-year-old was "on track" to participate in the tour and trained away from the rest of the team in their first session.
Stokes confirmed he will miss the first Test, which begins on Monday in Multan, and Ollie Pope will continue to deputise as captain in his absence.
"I tried my hardest to get myself fit for this game but have taken the call to miss this one because I've not quite managed to get game-ready," Stokes told BBC Sport.
"There is a lot that has to go into my rehab programme. We got to a certain point, but looking at the picture of what we've got coming up and physically where I'm at, I'm not quite ready to play.
"It's always frustrating to miss out. I've got some good things to focus on, so even though I'm not playing, I've got a goal in mind."
The second Test starts on October 15, but the all-rounder admitted he was not sure whether that was a realistic target for his return.
"I've pushed myself incredibly hard and worked really hard with the medical team to get to where I'm at now. I think I'm further ahead than what we expected," he added.
"I'll be working just as hard over the next 10 days to try to get myself fit for the second Test."
In his absence, Durham seamer Brydon Carse will make his England Test debut.
He has previously played 19 ODIs and four T20s for England and will make his red-ball bow just over a month after completing a three-month ban for historical gambling offences.
England XI for first Test against Pakistan: Zak Crawley, Ben Duckett, Ollie Pope (captain), Joe Root, Harry Brook, Jamie Smith, Chris Woakes, Gus Atkinson, Bryson Carse, Jack Leach, Shoaib Bashir.
Stokes a doubt for England's series opener against Pakistan
Ben Stokes is a doubt for England's three-match series in Pakistan, with Zak Crawley admitting they do not know if he will be fit to feature.
Stokes tore his hamstring playing for Northern Superchargers in The Hundred competition, forcing him to miss the side's last three matches against Sri Lanka, with England winning the series 2-1.
At the end of September, the captain underwent a planned scan which showed he was “on track” to feature in the series, although he was not expected to bowl at the start.
Stokes had been hoping to make his return in the series opener on Monday, but looked uncomfortable in England's first training session, and is yet to be given the green light.
"I think he's got to do a few more tests, but he's been doing some running and stuff," Crawley said.
"He seems to be going well, recovering well from his injury, [but] we don't know just yet. We feel ready, whatever team comes out, it will be a nice balance either way.
"We've got a really deep squad with plenty of options with the ball and with the bat as well."
If Stokes is available to play, they could have some selection headaches, as they would be forced to drop one of the top six batters with his inclusion to make way for an extra bowler.
If they do not drop a batter, they could rely on Joe Root, who could also make history as he has 12,402 runs for England in men's tests and is just 71 away from surpassing Alastair Cook (12,472) as the all-time leading run-scorer.
Crawley, meanwhile, has been cleared to feature after recovering from a broken finger that kept him out against Sri Lanka.
"I feel brand new. I'm looking forward to getting out there," Crawley added.
"I couldn't pick up a bat for five weeks. I've certainly missed it, so I can't wait to get out there again with the boys.
"It was a nasty break at the time, but I've recovered well, and I don't feel it at all while I'm batting.
"I won't go at slip, just from advice from the doctor, but I feel like I could. I'm trying to rest it, but I did a few catches, and it feels fine. I'm just trying to follow the professional advice."
Carsley: No more 'copy and paste' England squads
Interim England boss Lee Carsley says he will not "copy and paste" his squads, with players to be rewarded for strong club form with Three Lions call-ups.
Carsley oversaw 2-0 Nations League victories over the Republic of Ireland and Finland last month, having taken the reins on a temporary basis after Gareth Southgate's resignation.
The former under-21 boss announced his latest 25-man squad for upcoming matches against Greece and Finland on Thursday, making four changes from last month's party.
Tottenham striker Dominic Solanke won his first call-up in seven years, with Eberechi Eze, Harry Maguire, Tino Livramento and Jarrod Bowen all left out.
Predecessor Southgate was often criticised for sticking with a trusted core of players during his eight-year spell with the Three Lions, but Carsley says nobody is guaranteed a place under him.
"In the back of my mind, I wanted to make sure it feels fresh," Carsley said.
"When you get that email or WhatsApp to say that you've been called up, it's an achievement because it shouldn't be something that is taken for granted.
"I thought it was important that it was not just a copy and paste. I want them to feel like they have earned their place in the squad."
Tottenham midfielder James Maddison and Manchester United forward Marcus Rashford – both of whom were left out of Southgate's Euro 2024 squad – were among the players to be overlooked.
Carsley said he had been left with several tough decisions to make but had prioritised those in form in order to build rhythm before the 2026 World Cup qualifiers start next year.
"The players I've left out, I could make a case for them being in, but ultimately I have to make those decisions," Carsley said.
"The reality is you want a player to be coming in in top form and fighting for a position in the team.
"Getting out of this Nations League is important for us in terms of setting up World Cup qualification. Whether I'm here or not, it's important we are in a favourable pattern and in a position to win the World Cup."
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