Caelan Doris shone and Jack Conan suffered an injury scare as Ireland launched their World Cup warm-up fixtures by easing to a 33-17 win over Italy in Dublin.
Back-rower Conan departed the field shortly before half-time and was later pictured in a protective boot on the bench.
Full-back Jimmy O’Brien and scrum-half Craig Casey were also withdrawn for treatment to give head coach Andy Farrell cause for concern ahead of his side’s campaign in France, which kicks off in just five weeks’ time.
An experimental side missing a host of rested stars, in addition to suspended skipper Johnny Sexton, overcame a sloppy beginning to cruise to a 15th successive home victory.
Doris’ two tries, plus scores from Dave Kilcoyne, Stuart McCloskey and Cian Healy, earned victory, while Jack Crowley and debutant Ciaran Frawley kicked six and two points respectively.
Lorenzo Pani and Tommaso Menoncello claimed consolations for Italy but they never threatened to shock the Six Nations champions.
Ireland were back in action for the first time since clinching the Grand Slam against England in March.
Farrell retained only three of the players who began that day as part of an unfamiliar XV, while Italy included England-born debutants Paolo Odogwu and Dino Lamb in a strong selection.
The Aviva Stadium was far from full for the late kick-off and Ireland’s sluggish start, during which Tommaso Allan’s early penalty put the visitors ahead, initially did little to enhance the subdued atmosphere.
Italy lost Saracens prop Marco Riccioni to injury inside 10 minutes and that setback was quickly compounded by Kilcoyne burrowing over at the other end to register his first Test try since November 2014.
The score settled Ireland down to an extent and they capitalised on Italian indiscipline to stretch the scoreboard just before the half-hour mark.
Doris claimed the second try of the evening, crashing over wide on the right, moments after Azzurri loosehead Danilo Fischetti was sin-binned for failing to retreat.
Conan’s 35th-minute departure was an unwelcome sight for Farrell but the hosts’ performance continued to improve, with man-of-the-match Doris proving to be a real menace.
The Leinster man, selected in the unfamiliar position of openside flanker, produced a crushing tackle on Stephen Varney deep inside Italian territory to pave the way for McCloskey to power over.
Crowley landed his third conversion of the evening to make it 21-3 at the interval.
Farrell shuffled his pack slightly for the restart, introducing the uncapped Frawley at fly-half and pushing Crowley to full-back in place of the withdrawn O’Brien, who had received treatment on a shoulder issue.
A further change was required just four minutes later as scrum-half Casey followed Conan and O’Brien into the treatment room.
Italy, whose only Dublin success came in 1997, had struggled for territory in the opening period.
But, on the back of some cheap penalties conceded by Ireland, they reduced their deficit in the 51st minute when Pani was afforded yards of space on the right to charge forward and hold off the attempts of Jacob Stockdale.
Replacement prop Healy then celebrated moving level with Rory Best as Ireland’s third most-capped player on 124 appearances with his 12th international try.
Menoncello again reduced the arrears for Italy 12 minutes from time before the impressive Doris had the final say.
Following a week’s training camp in Portugal, Ireland move to matches against England and Samoa with plenty of positives but some fitness concerns.
Gatland future up in the air after Wales suffer 12th consecutive loss
Wales head coach Warren Gatland did not have answers about his future following their 45-12 defeat to South Africa, their 12th consecutive loss.
The Springboks dominated from the off and were cruising 26-0 just before half-time, after Franco Mostert, Eben Etzebeth, Kurt-Lee Arendse and Elrigh Louw crossed.
Rio Dyer's try before the break ensured Wales did not draw a blank in the first half, but South Africa did not let up as Aphelele Fassi, Gerhard Steenenkamp and Jordan Hendrikse all followed suit.
James Botham's late effort ensured Wales did not suffer their worst-ever home defeat, but they have now gone an entire calendar year without a win for the first time since 1937.
Gatland has come under increasing pressure as the losses pile up, and though his future remains up in the air, he was proud of how his inexperienced side held up against the world champions.
"It's about seeing what the Welsh Rugby Union has to say," he told TNT Sports when asked about his future.
"You don't make a decision straight after a game, it's always tough coming to a press conference straight after a game before you've had time to catch your breath and look at some of the stats and numbers.
"Let's just see what happens over the next few days."
On their recent run of form, he added: "We punched massively above our weight for a number of years, and we've been saying that when the dam bursts it's going to take a little bit of time to put things right.
"The dam has burst, but it's about making sure that, collectively, with the regions we work together.
"I think we need to be in better shape in a conditioning point of view. We will work on that with some of the players over the next couple of months, so when they turn up for the Six Nations, they're ready to go from day one."
South Africa have won each of their last three Tests, building on their wins over Scotland and England earlier in the series.
Captain Siya Kolisi was pleased with their ruthlessness in the game but also sympathised with Gatland's situation.
"It's been a really good tour," he told TNT Sports. "It hasn't been perfect, the first two games we weren't happy - happy we won, but there was so much we could have done better.
"The results are important, but it's how you do things, the standards we set for ourselves. We know we can do a little bit better as a group.
"We were where Wales are a couple of years ago.
"The only thing I can say is you just can't stop believing. If you look at their starting backline, one of our guys had more caps than all of them. You have to be realistic about these things."
Elsewhere, Ireland produced their most convincing win of their series, scoring eight tries as they cruised past Fiji 52-17 in Dublin earlier on Saturday.
France 37-23 Argentina: Les Bleus wrap up campaign with third win
France posted a comfortable 37-23 win over Argentina on Friday to make it three wins out of three tests at the Stade de France to conclude their Autumn Nations Series.
Having also beaten New Zealand and Japan in Paris this month, Fabien Galthie's side claimed four tries, including a superb solo effort from Louis Bielle-Biarrey, as they eased to victory against the Pumas.
The hosts led 30-9 at the break after Argentina's Julian Montoya and Juan Martin Gonzalez were both shown yellow cards in the first half, with Thomas Ramos slotting his third penalty of the game.
Tomas Albornoz made it 30-16 for Felipe Contepomi's visitors, but their hopes of a comeback were dashed as Bielle-Biarrey scored his fourth try in three games before Ramos made it 37-16.
Albornoz then cut the deficit to 37-23 with a two-pointer with nine minutes to play, but that wasn't enough to stop his side from falling to a defeat.
"We knew it was going to be an 80-minute game. We saw last week how Argentina went all the way against a good Irish team," France lock Emmanuel Meafou told TNT Sports.
"We are happy with the win. We have three from three [in the autumn] and we will look to build on that in the Six Nations next year."
England must be 'brave on the ball' to halt winless run, says Borthwick
England head coach Steve Borthwick has demanded his team to be "brave on the ball" when they take on Eddie Jones' Japan in the Autumn Nations Series on Sunday.
Borthwick's side have lost each of their last five matches, their longest such run since another five-game stretch between February and June 2018.
However, they have not lost more in a row since a streak of seven in 2006. Each of the five losses in their current streak have also come in single-digit margins.
But England have also struggled at home. They have fallen to defeat in their last three matches at the Allianz Stadium, their longest losing run since 2008.
Only once before have they lost more in a row at the Twickenham venue (L5 between 1971 and 1973), though Borthwick has urged his players to persist with an attacking style.
"We are trying to play the game a different way," he told BBC Sport.
"I am encouraging the players to be brave with the ball, to move the ball, that’s where the strength of the team now is and where it is going to be in the future."
Borthwick named his 23-man squad to face Japan on Friday, reinstating Tom Curry and Sam Underhill, nicknamed the "Kamikaze Kids" by Jones in 2019.
Curry has been recalled to the team after he was knocked out against Australia, and he replaces Chandler Cunningham-South in the back-row.
In the other change from the starting XV that lost to South Africa, full-back George Furbank comes in for Freddie Steward.
Fin Smith replaces George Ford on England's bench while Cunningham-South steps in for Alex Dombrandt. Sale's Opoku-Fordjour could also make his senior debut.
"We anticipate a tough challenge from a team that thrives on playing fast and with tempo," said Borthwick.
"Japan are a dangerous team, so it’s important that we execute our game plan and maintain focus throughout the full 80 minutes."
England team to face Japan
George Furbank, Tommy Freeman, Ollie Lawrence, Henry Slade, Ollie Sleightholme, Marcus Smith, Jack van Poortvliet, Ellis Genge, Jamie George, Will Stuart, Maro Itoje, George Martin, Tom Curry, Sam Underhill, Ben Earl.
Replacements: Luke Cowan-Dickie, Fin Baxter, Asher Opoku-Fordjour, Nick Isiekwe, Chandler Cunningham-South, Harry Randall, Fin Smith, Tom Roebuck.
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