Caelan Doris and Dan Sheehan have been passed fit to start Ireland's Grand Slam decider against England at the Aviva Stadium on the final weekend of Six Nations action.
The pair were two of five Ireland players to sustain injuries in last week's 22-7 victory over Scotland, which made it four wins from four for Ireland in this year's tournament.
While Garry Ringrose and Iain Henderson had already been ruled out for Saturday's meeting with England, Doris and Sheehan have been named in Andy Farrell's starting line-up.
Centre Robbie Henshaw and lock Ryan Baird come in for Ringrose and Henderson, while Jamison Gibson-Park takes over from Conor Murray as Farrell makes three changes.
Johnny Sexton starts his final Six Nations game ahead of retiring later this year, and the Irish captain needs one point to become the competition's outright all-time leading scorer.
Ireland will clinch a third Grand Slam in the Six Nations era – the others coming in 2009 and 2018 – and their fifth title overall if they defeat England in Dublin on Saturday.
Fourth-place England are looking to respond from a record home loss against France last time out and have made four changes to their starting XV.
Wing Henry Arundell is set to make his first start while Owen Farrell, the son of Ireland's coach, has been recalled at fly-half in place of the benched Marcus Smith.
Manu Tuilagi is also given a first start under Steve Borthwick in place of the injured Ollie Lawrence, and David Ribbans is brought in for Ollie Chessum in the other alteration.
Dan Cole is among England's replacements and will make his 100th Test appearance should he feature, making him just the fourth player to do so for the Red Rose.
England have lost their past two games against Ireland, conceding 32 points on both occasions, and have lost 13 of the past 23 encounters in the tournament.
Ireland XV: Hugo Keenan, Mack Hansen, Robbie Henshaw, Bundee Aki, James Lowe; Johnny Sexton (c), Jamison Gibson-Park; Andrew Porter, Dan Sheehan, Tadhg Furlong, Ryan Baird, James Ryan, Peter O'Mahony, Josh van der Flier, Caelan Doris.
Replacements: Rob Herring, Cian Healy, Tom O'Toole, Kieran Treadwell, Jack Conan, Conor Murray, Ross Byrne, Jimmy O'Brien.
England XV: Freddie Steward, Anthony Watson, Henry Slade, Many Tuilagi, Henry Arundell, Owen Farrell (c), Jack van Poortvliet; Ellis Genge, Jamie George, Kyle Sinckler, Maro Itoje, David Ribbans, Lewis Ludlam, Jack Willis, Alex Dombrandt.
Replacements: Jack Walker, Mako Vunipola, Dan Cole, Ben Curry, Nick Isiekwe, Alex Mitchell, Marcus Smith, Joe Marchant.