France will begin their quest to become the first side in six years to retain the Six Nations when they travel to perennial wooden spoon winners Italy on Sunday.
Les Blues ended a 12-year wait to get their hands back on the trophy last year, doing so in style as they claimed a Grand Slam with a perfect five wins from five.
Italy also ended last year's tournament on a high as they broke a 36-game losing run with victory in Wales and are now out to avoid finishing bottom for the first time since 2015.
While France may be reigning champions and in good form, Ireland are top of the world rankings and are many people's favourites to go one better than last year by finishing top.
Up first for Andy Farrell's Ireland side is a trip to Wales, who are in action for the first time since Warren Gatland replaced Wayne Pivac on the back of some alarming results last year.
England also have a new head coach in Steve Borthwick, who replaced Eddie Jones in December, with his first test a mouth-watering Calcutta Cup clash with Scotland.
Ahead of the opening round of action, Stats Perform previews each match with help from Opta.
WALES V IRELAND
FORM
Wales' loss to Italy was their third in a row in the Six Nations – only once since the start of 2008, at the end of their 2020 campaign, have they endured a longer winless run – but Gatland's return has provided fresh hope.
The Dragons won their last seven on the bounce in the championship under Gatland, who landed three Grand Slams in his previous 12-year spell in charge before stepping down in 2019.
Ireland have won seven of their past eight games in the tournament, winning the past three of those by margins of at least 17 points and conceding just one try in total.
However, the away team have not come out on top in any of the past nine Six Nations encounters between these sides, with the nations sharing four wins each over that period and one draw.
ONES TO WATCH
Wales are without the injured Leigh Halfpenny, meaning Liam Williams will start at full-back, but they have plenty of other familiar and experienced faces in their starting line-up – George North among them.
He is one try short of matching Shane Williams' record haul of 23 for Wales in the Six Nations, and behind only Brian O'Driscoll (26) of all players in the tournament's history.
Plenty of eyes will be on Johnny Sexton in what will be his final Six Nations campaign, but Ireland have many other players for Wales to concern themselves with.
James Lowe, returning from a calf injury that ruled him out of the November fixtures, will be looking to push on from last year when he finished level with Damian Penaud and Gabin Villiere as the joint-highest try scorer with three.
ENGLAND V SCOTLAND
FORM
Jones may have bowed out with the best win rate of any England head coach (73 per cent), but the Red Rose won just two of their final five home matches under the now-Australia boss – not since November 2008 have they had a longer winless run at Twickenham.
With former skipper Borthwick now at the helm as head coach, England are aiming to avoid losing their opening fixture in the tournament for a fourth year running, following a streak of five successive round-one wins.
Scotland have a far better recent record on the opening weekend than their opponents, having won four of their past six such matches, including the past two in a row – both against England.
Indeed, Scotland have lost just one of their past five Calcutta Cup clashes, having lost each of the previous seven. A victory on enemy territory this weekend will make it three wins in a row for the first time since 1972.
ONES TO WATCH
Manu Tuilagi's absence will be felt by England, who have handed a debut to wing Ollie Hassell-Collins, but Joe Marchant will add pace alongside exciting Harlequins team-mate Marcus Smith.
Smith was the top points-scorer in last year's Six Nations (71) and also registered over twice as many running metres as any other fly-half in the tournament (412), as well as beating more defenders than anyone other number 10 (10).
Hamish Watson is not ready for a return to the Scotland side this weekend in a blow for coach Gregor Townsend. The 31-year-old was one of just three players to make 50 or more tackles without missing one in the 2022 edition (70), along with team-mate Grant Gilchrist and Ireland's Caelan Doris (both 53).
Gilchrist is available, though, and he resumes a partnership with Richie Gray in the second row that impressed during Scotland's November internationals.
ITALY V FRANCE
FORM
The signs of improvement were clear to see from an Italy perspective in 2022 as they picked up a first win in the tournament since 2015 and then beat Australia for the first time ever in November's Test.
The Azzurri have now won five of their past seven Tests, as many as they had won in their previous 36 combined, but they have not won at home in the Six Nations since 2013 and have won back-to-back games in the championship just twice previously.
France enter the competition boasting a team-record 13-match winning run after winning every game in a calendar year for the first time in 2022. They were not always at their best towards the end of the year, though, with three of their past four wins coming by margins of five points or fewer.
Les Blues have won their opening match in each of their past four campaigns as reigning champions, which does not bode well for an Italy side who have won only two of their 23 Six Nations home matches against this weekend's opponents.
ONES TO WATCH
Italy are without the pace and power of Monty Ioane after he returned to Australia and became unavailable for selection in this championship. No player made more line breaks (seven), beat more defenders (21), completed more offloads (eight) and made more dominant tackles (seven) than Ioane in last year's Six Nations.
The Azzurri still have Pierre Bruno and Ange Capuozzo at their disposal, with the latter impressing on his tournament bow in 2022 en route to winning World Rugby's men's Breakthrough Player of the Year award.
Even with the likes of regular starters Jonathan Danty and Cameron Woki ruled out, France still boast a number of top-class talents in their squad.
Gregory Alldritt, who will combine with Charles Ollivon and Anthony Jelonch in the back row, made more carries than any other player in last year's tournament (65) and was one of two players, along with team-mate Julien Marchand (50), to hit 50 or more defensive rucks with 59.
Gatland future up in the air after Wales suffer 12th consecutive loss
Wales head coach Warren Gatland did not have answers about his future following their 45-12 defeat to South Africa, their 12th consecutive loss.
The Springboks dominated from the off and were cruising 26-0 just before half-time, after Franco Mostert, Eben Etzebeth, Kurt-Lee Arendse and Elrigh Louw crossed.
Rio Dyer's try before the break ensured Wales did not draw a blank in the first half, but South Africa did not let up as Aphelele Fassi, Gerhard Steenenkamp and Jordan Hendrikse all followed suit.
James Botham's late effort ensured Wales did not suffer their worst-ever home defeat, but they have now gone an entire calendar year without a win for the first time since 1937.
Gatland has come under increasing pressure as the losses pile up, and though his future remains up in the air, he was proud of how his inexperienced side held up against the world champions.
"It's about seeing what the Welsh Rugby Union has to say," he told TNT Sports when asked about his future.
"You don't make a decision straight after a game, it's always tough coming to a press conference straight after a game before you've had time to catch your breath and look at some of the stats and numbers.
"Let's just see what happens over the next few days."
On their recent run of form, he added: "We punched massively above our weight for a number of years, and we've been saying that when the dam bursts it's going to take a little bit of time to put things right.
"The dam has burst, but it's about making sure that, collectively, with the regions we work together.
"I think we need to be in better shape in a conditioning point of view. We will work on that with some of the players over the next couple of months, so when they turn up for the Six Nations, they're ready to go from day one."
South Africa have won each of their last three Tests, building on their wins over Scotland and England earlier in the series.
Captain Siya Kolisi was pleased with their ruthlessness in the game but also sympathised with Gatland's situation.
"It's been a really good tour," he told TNT Sports. "It hasn't been perfect, the first two games we weren't happy - happy we won, but there was so much we could have done better.
"The results are important, but it's how you do things, the standards we set for ourselves. We know we can do a little bit better as a group.
"We were where Wales are a couple of years ago.
"The only thing I can say is you just can't stop believing. If you look at their starting backline, one of our guys had more caps than all of them. You have to be realistic about these things."
Elsewhere, Ireland produced their most convincing win of their series, scoring eight tries as they cruised past Fiji 52-17 in Dublin earlier on Saturday.
Girona 4-1 Espanyol: Miovski bags double as hosts ride on first-half blitz
Bojan Miovski scored twice as Girona thrashed Espanyol 4-1 in LaLiga at Estadi Municipal de Montilivi on Saturday.
Bryan Gil and Ladislav Krejci were also on the scoresheet as the home side raced to a 4-0 lead inside the first half hour, with Javi Puado scoring the visiting side's only goal after the break.
After the match was halted because of a fan being taken ill in the crowd, Gil opened the scoring when he unleashed a stunning long-range strike into the bottom corner with four minutes on the clock.
Gil was behind the second goal for Michel's side too, as he capitalised on a defensive error and crossed to Miovski, who made it 2-0 in the 16th minute before the pair combined again for a third five minutes later.
Donny van de Beek's header from Yaser Asprilla's corner was pushed in by Krejci for Girona's fourth in the 27th minute.
Espanyol got a consolation goal 10 minutes into the second half when Puado hit a long-range strike that found the back of Paulo Gazzaniga's net.
Girona, last season's surprise package, climbed to fifth in LaLiga with 21 points, while Espanyol are 19th and in the relegation zone with 10 points.
Milan 0-0 Juventus: Bianconeri maintain unbeaten start after Rossoneri stalemate
Milan and Juventus shared the spoils following a dour goalless draw at San Siro.
The Bianconeri maintained their unbeaten start to the Serie A season, but missed the chance to go second behind leaders Inter after a game lacking in quality and chances.
With the likes of Dusan Vlahovic and Arkadiusz Milik out injured, Juventus began the game without a recognised striker, as Teun Koopmeiners and Weston McKennie led the line.
Koopmeiners hit the side-netting from a tight angle after 10 minutes, while Kenan Yildiz grazed the post following a fine individual run midway through the half.
Alvaro Morata had Milan's best chance at the other end, but the former Juventus striker could only head wide from Rafael Leao's free-kick.
Opportunities did not fall as freely in the second half either, and both teams left the field to a chorus of boos on the referee's final whistle.
Data Debrief: Stubborn Juve take clean sheet tally into double figures
Juve are the first team to register 10 clean sheets in their opening 13 matches of a Serie A season since Roma (also 10) in 2013-14.
The Bianconeri have also kept five clean sheets in their first six away league games in a campaign for only the fourth time, also achieving the feat in 1967-68, 2004-05, 2023-24.
Meanwhile, Thiago Motta is only the fifth Juventus manager to go unbeaten in his first 13 league matches in charge (won six, drawn seven), after Jesse Carver, Cestmir Vycpalek, Antonio Conte and Maurizio Sarri.
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