France will begin their quest to become the first side in six years to retain the Six Nations when they travel to perennial wooden spoon winners Italy on Sunday.
Les Blues ended a 12-year wait to get their hands back on the trophy last year, doing so in style as they claimed a Grand Slam with a perfect five wins from five.
Italy also ended last year's tournament on a high as they broke a 36-game losing run with victory in Wales and are now out to avoid finishing bottom for the first time since 2015.
While France may be reigning champions and in good form, Ireland are top of the world rankings and are many people's favourites to go one better than last year by finishing top.
Up first for Andy Farrell's Ireland side is a trip to Wales, who are in action for the first time since Warren Gatland replaced Wayne Pivac on the back of some alarming results last year.
England also have a new head coach in Steve Borthwick, who replaced Eddie Jones in December, with his first test a mouth-watering Calcutta Cup clash with Scotland.
Ahead of the opening round of action, Stats Perform previews each match with help from Opta.
WALES V IRELAND
FORM
Wales' loss to Italy was their third in a row in the Six Nations – only once since the start of 2008, at the end of their 2020 campaign, have they endured a longer winless run – but Gatland's return has provided fresh hope.
The Dragons won their last seven on the bounce in the championship under Gatland, who landed three Grand Slams in his previous 12-year spell in charge before stepping down in 2019.
Ireland have won seven of their past eight games in the tournament, winning the past three of those by margins of at least 17 points and conceding just one try in total.
However, the away team have not come out on top in any of the past nine Six Nations encounters between these sides, with the nations sharing four wins each over that period and one draw.
ONES TO WATCH
Wales are without the injured Leigh Halfpenny, meaning Liam Williams will start at full-back, but they have plenty of other familiar and experienced faces in their starting line-up – George North among them.
He is one try short of matching Shane Williams' record haul of 23 for Wales in the Six Nations, and behind only Brian O'Driscoll (26) of all players in the tournament's history.
Plenty of eyes will be on Johnny Sexton in what will be his final Six Nations campaign, but Ireland have many other players for Wales to concern themselves with.
James Lowe, returning from a calf injury that ruled him out of the November fixtures, will be looking to push on from last year when he finished level with Damian Penaud and Gabin Villiere as the joint-highest try scorer with three.
ENGLAND V SCOTLAND
FORM
Jones may have bowed out with the best win rate of any England head coach (73 per cent), but the Red Rose won just two of their final five home matches under the now-Australia boss – not since November 2008 have they had a longer winless run at Twickenham.
With former skipper Borthwick now at the helm as head coach, England are aiming to avoid losing their opening fixture in the tournament for a fourth year running, following a streak of five successive round-one wins.
Scotland have a far better recent record on the opening weekend than their opponents, having won four of their past six such matches, including the past two in a row – both against England.
Indeed, Scotland have lost just one of their past five Calcutta Cup clashes, having lost each of the previous seven. A victory on enemy territory this weekend will make it three wins in a row for the first time since 1972.
ONES TO WATCH
Manu Tuilagi's absence will be felt by England, who have handed a debut to wing Ollie Hassell-Collins, but Joe Marchant will add pace alongside exciting Harlequins team-mate Marcus Smith.
Smith was the top points-scorer in last year's Six Nations (71) and also registered over twice as many running metres as any other fly-half in the tournament (412), as well as beating more defenders than anyone other number 10 (10).
Hamish Watson is not ready for a return to the Scotland side this weekend in a blow for coach Gregor Townsend. The 31-year-old was one of just three players to make 50 or more tackles without missing one in the 2022 edition (70), along with team-mate Grant Gilchrist and Ireland's Caelan Doris (both 53).
Gilchrist is available, though, and he resumes a partnership with Richie Gray in the second row that impressed during Scotland's November internationals.
ITALY V FRANCE
FORM
The signs of improvement were clear to see from an Italy perspective in 2022 as they picked up a first win in the tournament since 2015 and then beat Australia for the first time ever in November's Test.
The Azzurri have now won five of their past seven Tests, as many as they had won in their previous 36 combined, but they have not won at home in the Six Nations since 2013 and have won back-to-back games in the championship just twice previously.
France enter the competition boasting a team-record 13-match winning run after winning every game in a calendar year for the first time in 2022. They were not always at their best towards the end of the year, though, with three of their past four wins coming by margins of five points or fewer.
Les Blues have won their opening match in each of their past four campaigns as reigning champions, which does not bode well for an Italy side who have won only two of their 23 Six Nations home matches against this weekend's opponents.
ONES TO WATCH
Italy are without the pace and power of Monty Ioane after he returned to Australia and became unavailable for selection in this championship. No player made more line breaks (seven), beat more defenders (21), completed more offloads (eight) and made more dominant tackles (seven) than Ioane in last year's Six Nations.
The Azzurri still have Pierre Bruno and Ange Capuozzo at their disposal, with the latter impressing on his tournament bow in 2022 en route to winning World Rugby's men's Breakthrough Player of the Year award.
Even with the likes of regular starters Jonathan Danty and Cameron Woki ruled out, France still boast a number of top-class talents in their squad.
Gregory Alldritt, who will combine with Charles Ollivon and Anthony Jelonch in the back row, made more carries than any other player in last year's tournament (65) and was one of two players, along with team-mate Julien Marchand (50), to hit 50 or more defensive rucks with 59.
“We have the manpower within the dressing room”- Sammy confident Windies can overcome 0-2 deficit against England
West Indies white ball head coach Daren Sammy says there’s still optimism in his camp that they can overcome the 0-2 deficit they currently face in their five-game T20I series against England.
The hosts lost the first two game of the series at the Kensington Oval in Barbados on Saturday and Sunday, with the rest of the series now shifting to the Daren Sammy Stadium in St. Lucia beginning with the third T20I on Thursday.
“Most definitely, especially here in St. Lucia,” Sammy said in a pre-match interview on Tuesday regarding his team’s optimism ahead of Thursday’s must-win game and the rest of the series.
“Yes, England have played better cricket than us in these first two games but I’ve rallied St. Lucia to come out and be the 12th man that we need here. We just haven’t played the brand of cricket that has allowed us to win and it’s something that we’re going to address but we have the manpower within that dressing room to win on Thursday and take it one game at a time,” he added.
The West Indies will be without two key players for the rest of the series in Andre Russell and Shamar Joseph.
Russell suffered an ankle injury in the first T20I on Saturday and has been ruled out for the rest of the series while Joseph has left the squad to prepare for the upcoming Test series against Bangladesh starting on November 22 in Antigua.
Replacing the pair are all-rounder Shamar Springer and spearhead Alzarri Joseph, returning to the squad after serving a two-game suspension.
“It’s always a blow to replace somebody like Andre Russell. We have young Shamar Springer who made his debut in Sri Lanka to replace him. He’s a really exciting prospect,” Sammy said.
“Shamar will go in and get ready for the Test series and Alzarri is back from his suspension. We’re looking forward to welcoming him and the experience he brings to the squad. Yes, we lose two key guys but we get two guys who are capable of doing the job for the team as well,” he added.
Harwood-Bellis 'didn't quite believe' first senior England call-up
Taylor Harwood-Bellis revealed he was in a state of disbelief when he was told about his first call-up to the England senior team last week.
Harwood-Bellis, along with Newcastle's Lewis Hall, received their maiden Three Lions call-ups in Lee Carsley's final squad as interim head coach.
The Southampton defender has impressed under Russell Martin this season, featuring in all of their Premier League fixtures so far this season.
Harwood-Bellis has won more aerial duels (13) for the Saints in the top-flight this term, with only Jan Bednarek (888) completing more passes than the 22-year-old (684).
He is also someone well known to the interim boss from his time in charge of England's Under-21's side, with his 21 appearances more than any other player during Carsley's tenure in the current Three Lions squad.
"Lee Carsley rang me in the morning and said, 'you'll be with us, with the seniors'. I didn't quite believe it at first," he told a press conference.
"My partner was next to me and I phoned my dad, who was very proud. He loves when I play for England, even the younger age groups.
"One of the first people to message me was Aaron Ramsdale. I was happy to see his name as he's one of my mates at the club."
Unfortunately for Harwood-Bellis, Ramsdale has since pulled out of the squad with a finger injury and has been replaced by Burnley's James Trafford.
England travel to Athens to take on Group B2 leaders Greece on Thursday before returning to Wembley three days later as they square off against the Republic of Ireland.
With a number of first-team regulars out through injury, Harwood-Bellis has the opportunity to become the first Saints player to represent England since Kyle Walker-Peters did so back in 2022.
The defender understood the potential ramifications of performing well for the Three Lions during this international break, with Thomas Tuchel taking over in the new year.
"It will be a big motivation for all of the lads, knowing that there's a new manager coming in and wanting to keep your spot," he said.
"That's something that especially the younger lads will be pushing towards.
"It's going to be difficult because of the quality and experience in some of the lads that aren't here is massive.
"It'll be difficult, but it'll be something that I'll focus on week in and week out for Southampton and if I get minutes here."
Springboks aiming to have 'two best teams in the world', says Esterhuizen
South Africa centre Andre Esterhuizen said that the Springboks are aiming to have "the two best teams in the world" ahead of their Autumn Nations Series clash against England.
The world champions were pushed all the way by Scotland in their narrow victory at Murrayfield on Sunday, though head coach Rassie Erasmus opted to rotate some key starting positions.
South Africa captain Siya Kolisi and flanker Pieter-Steph du Toit started on the bench, with the changes a common theme during Erasmus' seven-year tenure.
Their opening Autumn Nations Series victory also put them back on top of the world rankings after Ireland's first defeat in 19 home games by New Zealand on Friday.
"One of the good things is that everyone is getting game time now," Esterhuizen told the BBC's Rugby Union Weekly podcast.
"It is also about looking forward, you've got to be able to spare all the guys for the next World Cup and build experience into it.
"The aim is to have the two best teams in the world, all in one squad.
"We want to make it second nature for people slotting in, so if someone steps in, they can just slot in and play the same if not better than the other player."
South Africa next face England, who are yet to pick up a win this autumn, at Twickenham on Saturday.
Steve Borthwick's side suffered a narrow two-point defeat by New Zealand, before conceding an injury-time winning try to Australia on Saturday.
England have now lost each of their last four Test matches, their longest such run since losing five straight games in 2018, but Esterhuizen's former Harlequins team-mate Marcus Smith has been impressive for the Red Roses.
"It's a great space, I obviously love to play there," Esterhuizen added. "It will be great to be running at Marcus, not run off him.
"It's going to be a great match, England have played well in the last few games, it's unfortunate that it hasn't been the results that they want. I think it's going to be a big one."
The Springboks have won three of their last four matches against England (L1), including each of their last two. Three of the last five games between England and South Africa have been decided by single-point margins.
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