Andy Farrell has been able to call on Johnny Sexton to captain Ireland in their Six Nations opener against Wales on Saturday.
Sexton, who is set to participate in his final Six Nations ahead of retirement later this year, was a doubt for the tournament after undergoing surgery on a cheek injury last month.
But the 37-year-old has recovered and was named skipper for the clash at the Principality Stadium, where the roof will be closed at Ireland's request.
Jamison Gibson-Park will partner Sexton in the backs.
Prop Tadhg Furlong is not fit to play due to a calf injury, with Finlay Bealham starting in his place, while Robbie Henshaw is also absent.
Stuart McCloskey has been picked ahead of Bundee Aki in Henshaw's position and is set for his first Six Nations appearance since 2016.
There was bad news for Wales on the injury front on Wednesday, with Leigh Halfpenny – who had been given the nod at full-back by Warren Gatland – withdrawing after suffering a back spasm.
Liam Williams will start in Halfpenny's stead, despite concerns over his own fitness after a string of injuries.
Ireland team: Hugo Keenan, Mack Hansen, Garry Ringrose, Stuart McCloskey, James Lowe, Johnny Sexton, Jamison Gibson Park; Andrew Porter, Dan Sheehan, Finlay Bealham, Tadhg Beirne, James Ryan, Peter O'Mahony, Josh van der Flier, Caelan Doris.
Replacements: Rob Herring, Cian Healy, Tom O'Toole, Iain Henderson, Jack Conan, Conor Murray, Ross Byrne, Bundee Aki.