James O'Connor will start at fly-half, while Rory Arnold and Lalakai Foketi have also been included in the Australia side to face Argentina in the Rugby Championship on Saturday.
O'Connor gets the nod to don the number 10 shirt in the absence of Quade Cooper, who suffered an Achilles injury in the 41-26 win over the Pumas last weekend.
Arnold has recovered from a calf injury and the lock will make his first Wallabies start of the year at Estadio Bicentenario.
Centre Lalakai Foketi has been handed a maiden start by Dave Rennie, partnering Len Ikitau, and prop Taniela Tupo is back in the team in San Juan after Allan Alaalatoa returned home for personal reasons.
Pone Fa'amausili is set to make his debut off the bench, while Irae Simone is also among the replacements.
Australia head coach Rennie said: "After a tough, physical game last week it's great to be able to call on the experience of guys like James and Rory and also see the team's excitement for La and Irae who get to wear the Wallaby gold again on Saturday.
"It's going to be a proud occasion for Pone and his family and it's a testament to him for the hard work and obstacles he's had to overcome to earn his first Test cap."
Australia team: Tom Wright, Jordan Petaia, Len Ikitau, Lalakai Foketi, Marika Koroibete, James O'Connor, Nic White; James Slipper (captain), Folau Fainga’a, Taniela Tupou, Rory Arnold, Darcy Swain, Jed Holloway, Fraser McReight, Rob Valetini.
Replacements: Lachlan Lonergan, Matt Gibbon, Pone Fa'amausili, Nick Frost, Pete Samu, Tate McDermott, Irae Simone, Reece Hodge.