Lorenzo Musetti headlined a day of shocks at the Monte Carlo Masters as Felix Auger-Aliassime fell to a first-round defeat.
Auger-Aliassime already has one singles title to his name this year, having prevailed in Rotterdam, and also reached the final of the Open 13 in Marseille and helped Canada to victory in the ATP Cup at the start of 2022.
However, the sixth seed entered this contest with just one win from his last four matches and came unstuck once again at the hands of Musetti.
Musetti, who won two sets in the fourth round of the French Open against Novak Djokovic last year, is very much at home on the clay in Monaco.
He demonstrated that in 6-2 7-6 (7-2) success, setting up a last-16 meeting with Diego Schwartzman.
“I live here and practice here,” Musetti said in his on-court interview. "It is nice to be here and play here in front of such a crowd. I am really happy.
"My backhand down the line was a key to many of my great shots. After a really good first set, he came back with such powerful serving, but I was calm and patient and that was the most beautiful thing about today."
Auger-Aliassime's exit came a day after top seed Djokovic was knocked out in the second round by Alejandro Davidovich Fokina, but there were no such problems for second seed Alexander Zverev as he saw off Federico Delbonis in straight sets.
Fifth seed Andrey Rublev came from a set down to defeat Alex de Minaur and fourth seed Casper Ruud, coming off his defeat in the final in Miami, edged qualifier Holger Rune in two tight sets.
The man who vanquished Ruud in Florida will go no further on the Cote d'Azur, however, Carlos Alcaraz losing in just over three hours to Sebastian Korda on his Monte Carlo debut.
Korda lost to Alcaraz in the final of last year's Next Gen ATP Finals, but avenged that defeat with a 7-6 (7-2) 6-7 (5-7) 6-3 victory.
World number 10 Cameron Norrie lost to Albert-Ramos Vinolas and his British compatriot Dan Evans fell to David Goffin, while 16th seed Lorenzo Sonego was beaten by the in-form Laslo Djere.
Elsewhere in the draw, there were wins for Jannik Sinner, Taylor Fritz, Hubert Hurkacz and Pablo Carreno Busta.
US Open: ATP's next generation pushing each other, says Sinner
After triumphing at Flushing Meadows, Jannik Sinner feels the next generation of stars on the ATP Tour push each other on.
Sinner won his second grand slam title by beating Taylor Fritz 6-3 6-4 7-5 in the US Open final on Sunday.
The Italian became the third youngest player in the Open Era to win the title at the Cincinnati Open and Flushing Meadows during the same season after Andy Roddick (2003) and John McEnroe (1981).
He is the third youngest player during the Open Era to register a minimum of 23 wins in grand slam matches during a single season, older only than Pete Sampras (23-2, 1993) and Rafael Nadal (24-2, 2008).
And while Novak Djokovic is still going strong, Sinner and Carlos Alcaraz are spearheading a new generation of stars that are already living up to their potential.
"I feel like the new generation, we push each other," the world number one told ESPN after his win over 26-year-old Fritz.
"I always have players who are going to make me a better player, because there are going to be times where they beat me.
"Then you have to try to find a way how to win against certain players."
Alcaraz was among those to congratulate Sinner, with the Spaniard posting on his Instagram story after the final.
Fritz, meanwhile, became the second oldest American male in the Open Era to reach a maiden men's singles final at a grand slam, after MaliVai Washington (27 years 15 days) at Wimbledon in 1996.
He was looking to emulate Roddick's success from 2003, ending a 21-year wait for a homegrown champion at Flushing Meadows, but could not get over the line.
"There's obviously a lot of positives, and when I get some time to cool down then I'll be happy about the fact that I made it to the finals," reflected Fritz, who feels like he let fans down.
"But right now I'm pretty disappointed in just a lot of things on the court, how I played, how I hit certain shots. It sucks.
"And I'm not saying that it necessarily would have made a difference. I don't know if it would have, but I just would have liked to have played better and given myself a better chance. It's really disappointing right now.
"I feel like the fans obviously, American fans, been wanting a men's champion for a long time, and I'm pretty upset with how I played. I feel like, I don't know, I feel like I almost let a lot of people down."
US Open: Fritz 'sorry' for not providing crowd with home victory
Taylor Fritz said he was "sorry" he could not provide home victory in the US Open after losing in straight sets to world number one Jannik Sinner in the final.
It has been 21 years since an American claimed the US Open title when Andy Roddick won in straight sets in 2003 against Juan Carlos Ferrero.
Fritz became the first American to reach the final since Roddick lost to Roger Federer in 2006, after beating Frances Tiafoe in the semi-finals.
He also registered impressive victories against Alexander Zverev and Casper Ruud on his route to the final.
Yet he came up short against the reigning Australian Open champion, losing 6-3 6-4 7-5 in the final in front of a home crowd at Flushing Meadows.
"Thanks to the fans. Being an American at the US Open is incredible, feeling the love all week," said Fritz after the final.
"I know we've been waiting for a champion for a long time, so I'm sorry I couldn't get it done this time, but I'm going to keep working and, hopefully, the next time."
Fritz became the second-oldest American (26 years and 313 days) in the Open era to reach a maiden men's singles final at a grand slam.
"It's been an amazing two weeks and congrats to Jannik, he played a great match. It was really impressive, he was too good," he added.
US Open: Sinner delighted to cap 'incredible' year with second major title
Jannik Sinner is proud of his "incredible year" but is still targeting improvements despite picking up his second grand slam win at the US Open.
The Italian edged a tight contest in straight sets, claiming his maiden title at Flushing Meadows with a 6-3 6-4 7-5 victory over home favourite Taylor Fritz on Sunday.
In the process, the world number one became just the third player to win the title at the US Open men's singles after dropping his opening set at the event in the past five decades, after John McEnroe (1981) and Patrick Rafter (1998).
Sinner fell behind in the final set and had to dig deep to overcome Fritz's late fight, and said that his self-belief ultimately carried him over the line.
"I just went day by day. Believing in yourself is the most important," Sinner said in his on-court interview.
"I understood, especially in this tournament, how important the mental part is in sport.
"It's been an incredible year. So many big wins, starting off in Australia which gave me confidence until now.
"The work never stops. I know I can still improve. I can't wait for my continued process.
"I love tennis. I practice a lot for this kind of stage. I know how much work Taylor puts in. He's doing an amazing job and congrats to you and the whole team.
"It's so nice to see you on big stages like this, and I'm quite sure there will be many more. I wish you the best of luck for the future."
Just before the start of the US Open, Sinner was cleared following an investigation, having twice tested positive for a banned substance in March.
The 23-year-old was inadvertently contaminated by a low level of a metabolite of clostebol – a steroid that can be used to build muscle mass – by his physiotherapist, who had used an over-the-counter spray for a cut on his own hand before treating the player.
With many worried about how that would affect Sinner's focus in New York, he credited his team for helping him get through the tough period.
"This title for me means so much because the last period of my career was really not easy," Sinner added.
"My team and the people who are close to me have supported me every day. I'm very happy and proud to share this moment with my team."
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