Defending champion Simona Halep has withdrawn from Wimbledon due to a calf injury.
Halep has been out of action since she was helped off the court after suffering a tear of her left calf during a match against Angelique Kerber in Rome last month.
The two-time grand slam champion had hoped to be fit to defend her title at the All England Club after travelling to London, but pulled out just three days before the tournament gets under way.
"It is with great sadness that I'm announcing my withdrawal from The Championships as my calf injury has not fully recovered," said the 29-year-old Romanian, who also missed the French Open.
"I gave it everything I had in order to be ready to play Wimbledon and after having such special memories from two years ago, I was excited and honoured to step back on these beautiful courts as defending champion.
"Unfortunately, my body didn't cooperate and I'll have to save that feeling for next year.
"I can honestly say that I'm really down and upset about having to take this decision. This period has been difficult but to miss the last two majors has made it even more challenging mentally and physically.
"We will see what the future holds but I'm hoping it will make me a stronger person and athlete.
"Thank you to everyone at Wimbledon for your understanding and support."
Halep won her first Wimbledon title two years ago, outclassing Serena Williams 6-2 6-2 on Centre Court.
Murray eliminated by Lajovic in Miami Open first-round upset, Monfils retires injured
Two-time Miami Open champion Andy Murray has been eliminated in the first round of this year's event after a shock 6-4 7-5 loss to world number 76 Dusan Lajovic on Wednesday.
Murray, ranked 53rd in the world, could not find his usual return with Lajovic winning 72 per cent of second-serve points, prevailing in one hour and 38 minutes.
The Serbian claimed only his fourth win out of 16 matches on hard courts since the start of last year, holding his nerve after failing to serve out the match at 5-4 in the second set, converting his third match point in the 12th game.
Lajovic hit 21-14 winners, with Murray committing more unforced errors (15-13). The Serbian converted all three break points he generated.
Former world number six Gael Monfils was forced to retire due to a right wrist injury in his clash with French compatriot Ugo Humbert at 3-3.
Monfils, 36, was playing at only his third event since returning to the ATP Tour following seven months out due to injury.
Argentina's Facundo Bagnis defeated Brazilian qualifier Felipe Meligeni Alves 6-3 1-6 6-4, with his reward a second-round clash with last week's Indian Wells Open winner and top seed Carlos Alcaraz.
World number 50 J.J. Wolf beat world number 48 Alexander Bublik 7-5 6-3 in 79 minutes, earning a second-round clash with sixth seed Andrey Rublev.
World number 74 Martin Fucsovics sent down nine aces as he beat Argentina's Pedro Cachin 6-4 7-6 (7-2) in 107 minutes. Fucsovics will next face seventh seed Holger Rune.
Ilya Ivashka beat Daniel Altmaier 6-2 6-1 to book a second-round clash with third seed Casper Ruud, while Fabio Fognini bowed out, losing 6-4 5-7 6-4 to Jan-Lennard Struff. USA's Brandon Nakashima powered to a 7-6 (7-3) 6-3 victory over Germany's Oscar Otte.
Raducanu exits in Miami Open first round against former US Open champion Andreescu
Emma Raducanu was bundled out of the Miami Open in the first round by form US Open champion Bianca Andreescu in a three-set match that lasted two hours and 35 minutes on Wednesday.
The Briton, who won the US Open in 2021, went down 6-3 3-6 6-2 in a genuine tug-of-war against the 31st-ranked Canadian.
Andreescu sent down seven aces for the match, including four in the first set along with 12 winners as she claimed an early lead.
Raducanu responded with greater aggression, securing the crucial break in the eighth game, before serving out to level the contest.
But Andreescu showed composure and quality in the big points in the final set, winning the final four games to round out the victory, sealing a second-round clash with seventh seed Maria Sakkari.
Andreescu finished with 32 winners compared to Raducanu's 20, while the Briton committed 40 unforced errors.
World number 42 Shelby Rogers edged out USA compatriot Sloane Stephens in just under two hours, winning 6-4 3-6 6-2. Rogers will take on second seed Aryna Sabalenka, who is arguably the tournament favourite after top seed Iga Swiatek's withdrawal, in the next round.
Rogers was one of five Americans to progress, including 2020 Australian Open champion Sofia Kenin who defeated Australia's Storm Hunter 6-0 7-6 (7-5).
World number 35 Amanda Anisimova retired down 7-6 (7-5) 5-2 to countrywoman Madison Brengle.
Leylah Fernandez, the player whom Raducanu beat in the 2021 US Open final, advanced into the second round with a 6-4 6-3 victory over Lesia Tsurenko in 88 minutes.
World number one Swiatek withdraws from Miami Open due to rib injury
Iga Swiatek has withdrawn from the Miami Open with a rib injury.
The world number was due to defend her title, having won the tournament last year without dropping a set.
However, she will be unable to feature in Florida due to an ongoing rib issue that has plagued her since the Qatar Open in February.
Swiatek reached the semi-finals of the Indian Wells Open last week, losing to eventual champion Elena Rybakina, and hinted at concerns over her condition.
The Pole confirmed on Wednesday that after consulting with her medical team, she will not play her second-round match against Claire Liu on Thursday and will also miss the Billie Jean King Cup, which takes place in April.
"You know that in and after Doha I was struggling with a strong infection," Swiatek said.
"I was allowed to play, but a strong episode of tough cough led to a rib injury. We were trying to handle it and continue to play as long as it was safe for me. We were analysing the data in the last [few] days and my doctor prepared my diagnosis.
"Unfortunately, I'm still feeling a lot of discomfort and pain and I can't compete.
"I will keep you updated about where I play next, because it depends on my process of recovering and the recommendation of my medical team.
"I have the best team behind me, we only need some time to deal with the injury. It's a truly difficult call to not play in Miami and the Billie Jean King Cup, but health is the most important [thing].
"I'm grateful this is the first health issue in a long time and I was able to compete in perfect shape for so long, but that's sports, it happens sometimes, without our control.
"Time to accept it and get well as soon as possible."
Swiatek will be replaced in the women's draw by lucky loser Julia Grabher.
The 21-year-old will now hope to be fully fit in time for the clay-court season, including the French Open, where she is the reigning champion.
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