Dominic Thiem will seek the advice of a specialist in Barcelona after suffering an injury scare ahead of Wimbledon next week.
Number two seed Thiem retired due to a wrist injury when 5-2 up in the opening set against Adrian Mannarino in the Mallorca Championships on Tuesday.
An MRI conducted at a Mallorca hospital was inconclusive, so the US Open champion will now undergo further tests.
In an update on Wednesday, Thiem wrote on social media: "Yesterday during the match I had a problem with my wrist.
"I went immediately to do an MRI at the hospital in Palma de Mallorca. The results weren't that clear and I have decided to go to Barcelona to check with a specialist.
"I hope I can get the results and a clear diagnosis in the next days."
The ATP 250 event continued without him in Mallorca, as Roberto Bautista Agut moved into the quarter-finals with a 6-3 7-5 triumph over Italian Stefano Travaglia.
More Spanish success on home soil arrived as Pablo Carreno Busta won 6-4 6-4 against Jiri Vesely.
In the doubles, Novak Djokovic and Carlos Gomez-Herrera saw off top seeds Marcel Granollers and Horacio Zeballos to reach the last four in that competition.
Djokovic appears to be enjoying himself as he continues to prepare for Wimbledon, saying: "This was a huge win for us, beating one of the best doubles players in the world after losing the first set.
"We are having a lot of fun on the court. I thought we played well even though we lost the first set."
There was a major upset at the Viking International in Eastbourne, meanwhile, with number one seed Gael Monfils suffering a shock last-16 defeat to Australia's Max Purcell – ranked number 283 in the world.
Purcell, who is only in the tournament as a lucky loser, claimed a huge 6-4 5-7 6-4 win in a battle lasting over two hours.
Monfils fired down 16 aces and fought back after being within two points of defeat in the second set but was ultimately beaten and has not made an ATP quarter-final since February 2020.
"It feels unbelievable," said Purcell. "I thought I'd come out and have a go.
"I've struggled to get into any singles events over the past nine months and primarily played doubles, so to get on a run here, on my favourite surface, is great."
Purcell will take on Andreas Seppi – a comfortable winner over Emil Ruusuvuori – in the last eight.
While Monfils crashed out, there was less drama for the second and third seeds.
Alex de Minaur won 6-3 6-4 against home hope Liam Broady, while Lorenzo Sonego was a 6-4 6-2 victor in his contest with John Millman.
World number one Swiatek sees off Xiyu in Madrid opener
World number one Iga Swiatek overcame Wang Xiyu with the minimum of fuss on Thursday to progress to the third round of the Madrid Open.
Swiatek has yet to win the title in Madrid, which is the only clay-court European event at which the Pole has not triumphed, but she got off to a flying start with a 6-1 6-4 victory over Xiyu.
"I love this place. I got to know the city a little better last year," Swiatek said. "So this time I feel more comfortable around."
Next up for the 22-year-old is a third-round tie against 27th seed Sorana Cirstea on Saturday.
Data Debrief
Swiatek has registered 150 match wins on the WTA Tour since the start of 2022. Elena Rybakina and Coco Gauff are the next best with 108 wins each.
She also became the first player born this century to claim 50 combined match wins in Madrid, Rome and Roland-Garros, since the inaugural women's singles event at the Madrid Open in 2009.
Dominant Gauff double bagels Rus at Madrid Open
Coco Gauff made a flying start to her Madrid Open campaign on Thursday, recording the first double bagel main-draw win of her career as she cruised past Arantxa Rus to reach the round of 32.
Gauff needed just 51 minutes to see off 33-year-old Rus as she booked a meeting with Ukraine's Dayana Yamstremska for Saturday.
The US Open champion lost just 18 points throughout the match – eight in the opener and 10 in the second set – as she put any doubts over her recent form to bed in emphatic fashion.
Gauff's power proved too much for Rus in the opener, the third seed winning 88 per cent of points behind her first serve and converting three of four break points to go a set up in just 23 minutes.
Rus brought up four break points midway through the second set, but when she failed to convert them, Gauff punished her in ruthless fashion by reeling off another three games then finishing things with a terrific forehand winner.
Speaking after her win, the American said: "I played really well today. It was just one of those days for me… 6-0 6-0, I've never done that before, I'll probably never do it again."
Data Debrief: Gauff matches Azarenka, Halep feat
Gauff is just the third player to register a 6-0 6-0 win in the women's singles draw at the Madrid Open, following in the footsteps of two former world number ones in Victoria Azarenka and Simona Halep.
The American, who only turned 20 last month, is also the youngest player to double bagel an opponent in any main-draw match on the WTA Tour since Iga Swiatek did so against Karolina Pliskova in the 2021 Italian Open final in Rome.
Nadal cruises past teen Blanch to tee up De Minaur rematch in Madrid
Darwin Blanch presented little challenge for Rafael Nadal, who dropped just one game in a convincing 6-1 6-0 triumph at the Madrid Open.
Nadal is feeling his way back to fitness, but 16-year-old qualifier Blanch offered little resistance to the 22-time major champion on Thursday.
Making his farewell appearance at the Madrid Open, where he has won five titles, Nadal needed just 64 minutes to progress to round two.
"I think today I played against an opponent with a great future in front [of him], but today, still making mistakes," said Nadal.
"I just tried to be there, be solid all the time without taking a lot of risks. It worked well. I'm happy to be through and I wish him all the very best for the future."
Nadal's reward is a rematch with Alex de Minaur, who he lost to last week in Barcelona.
Data Debrief
This game saw the largest age gap (21 years, 117 days) between two opponents in the history of ATP Masters 1000 events.
Nadal has now registered 57 wins at the Madrid Open, which is 20 clear of any other player.
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