Rafael Nadal saw off Alexei Popyrin to reach the Madrid Open quarter-finals on a day that saw Daniil Medvedev and Stefanos Tsitsipas suffer surprise defeats.
World number two Nadal, chasing a record-extending sixth title on home soil, advanced 6-3 6-3 in a time of one hour and two minutes on Thursday.
Popyrin, playing in his first last-16 match at a Masters 1000 event, broke Nadal in the sixth game of the opening set but the Spaniard otherwise looked comfortable.
Nadal converted four of his six break points to advance through to the last eight for a 15th time, where Alexander Zverev awaits.
"It was difficult," Nadal said in his on-court interview. "The court today was slippery, it was very fast, very dry conditions. The ball was flying a lot. The beginning was super tough.
"He was hitting every ball and hitting the spots. I'm happy with the victory. It was an important victory, he came here playing well. Every match is tough."
Zverev, who won the competition in 2018, beat British number one Dan Evans 6-3 7-6 (7-3) to set up a meeting with Nadal
However, second and fourth seeds Medvedev and Tsitsipas saw their participation come to an end at the hands of Cristian Garin and Casper Ruud respectively.
Medvedev, who is still yet to reach the quarters in Madrid, lost the only break of serve in the third game of the opening set but recovered by taking the second set in a tie-break.
Garin dominated the deciding set, the world number 25 breaking Medvedev twice and, after a short delay to fix a broken net, advanced 6-4 6-7 (7-2) 6-1.
Tsitsipas, who held championship point against Nadal in the Barcelona Open final, failed to break Ruud on a single occasion as he fell 7-6 (7-4) 6-4.
Alexander Bublik is next up for Ruud after beating Aslan Karatsev 6-4 6-3, while Matteo Berrettini - 7-6 (7-4) 6-4 winner against Federico Delbonis - will meet Garin.
Also vying for a place in the semi-finals are John Isner and Dominic Thiem, who are set to face off after beating sixth seed Andrey Rublev and Alex de Minaur respectively.
'Not my goal at all' - Djokovic not committing to ATP Finals appearance
Novak Djokovic "can't say" if he will compete in the upcoming ATP Finals in November as he becomes more selective about which tournaments he participates in.
The Serbian has struggled with injuries and a lack of form in 2024, and he will finish a calendar year without a grand slam title for the first time since 2017.
His last major triumph came at the US Open last year, but he failed to defend his crown, suffering a shock early exit to Alexei Popyrin in the third round at Flushing Meadows.
Djokovic is just one grand slam trophy away from becoming the outright record holder, currently sitting level with Margaret Court on 24 titles.
He reached the Wimbledon final in July, only to lose out to Carlos Alcaraz, though he did win his first Olympic gold in Paris by beating the Spaniard the following month.
The 37-year-old is currently representing Serbia at the Davis Cup and stressed that he will be prioritising certain tournaments over others.
"Torino is not my goal at all, to be honest, I am not chasing ATP Finals, I am not chasing the rankings etc," he told Serbian reporters after beating Greece's Ioannis Xilas on Saturday.
"As far as I am concerned, I am done with those tournaments for my career. Whether I will play other tournaments this year or in the future, I can't say right now.
"My main priorities are playing for the national team and slams, everything else is less important.
"Weeks like these represent another motivation, they inspire me to keep going, they awake those butterflies in my belly.
"I thought that I would never have to seek motivation anywhere, it all used to come naturally – automatically – but that has not been the case in the last few years.
"In order to prolong my career, I need to enjoy, I need to choose wisely tournaments I am going to play."
Following the Davis Cup, Djokovic will play in an exhibition tournament in Sofia and in the ATP 1000 event in Shanghai at the start of October.
"After that [Shanghai], I am going to see what I am going to do," Djokovic added.
"Usually in my career I used to have my schedule ready six months in advance, but nowadays, that's not the case. Now it's more spontaneous.
"Firstly, I need to physically, emotionally and mentally rest in order to even start thinking what I want to do next, in what way, how much and where."
Djokovic keeps Serbia on track as Ruud seals Norway win
Novak Djokovic marked his return to action with a dominant 6-0 6-1 victory over Greece's Ioannis Xilas to put Serbia in control of the Davis Cup tie.
The 24-time major winner was playing his first match since his US Open third-round defeat by Alexei Popyrin at Flushing Meadows a fortnight ago.
And Djokovic, who helped his nation win the Davis Cup in 2010, looked close to his best as he dropped just a single game, while converting five of the seven break points he forced.
Wrapping up a dominant victory in just 45 minutes, he put Serbia 2-0 to the good in the World Group I tie.
Elsewhere in that group, Casper Ruud helped Norway wrap up a 3-1 win over Portugal.
The three-time major finalist, who put his nation 2-1 to the good alongside Viktor Durasovic in the doubles rubber, was a 7-6 (7-3) 6-2 victor over Jaime Faria in their singles clash.
Later in the day, Argentina booked their place in the final eight after Maximo Gonzalez and Andres Molteni saw off Finland in the doubles decider.
Nadal unsure of future involvements after Laver Cup withdrawal
Rafael Nadal says he cannot commit himself to future tournaments after his withdrawal from the Laver Cup.
Nadal shared news on Thursday that he would not make an appearance at the annual event in Berlin, stating that it would not be in the best interests of Team Europe if he were to participate.
The Spaniard was last in action playing doubles at the Paris Olympics with Carlos Alcaraz, and while he says he is in a good space mentally, he was not able to confirm when he would next make a professional appearance on a tennis court.
He said: "Mentally, I’m good, no problems. I'm at home enjoying other things, training as much as I can every day.
"No drama, obviously these are decisions [the Laver Cup withdrawal] that are being made, and this was a possibility - it's been a while without competing. There will be someone else who can do better.
"Right now I’m not in a position to put myself down for anything.
"I said [I would play] until the Olympics and then we would see, and I'm in that period of rest."
Nadal has endured a difficult 2024 so far, playing just 21 competitive singles matches with a record of 13-8.
He has only one grand slam victory to his name this year, beating Jack Draper in the Australian Open, but he lost in the first round of the French Open to eventual finalist Alexander Zverev.
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