Top seed Dan Evans was knocked out of the Sardegna Open as Lorenzo Musetti saved four match points to progress to the quarter-finals.
NIneteen-year-old Musetti trailed 6-3 in the third-set tie-break after letting an earlier match point slip through his grasp.
But Evans could not convert any of his first three match points and, after Musetti let another one go begging, the Briton failed to take advantage of his fourth opportunity.
Evans' profligacy eventually proved costly, Musetti converting his third match point with a well-executed forehand drop shot to clinch a 6-1 1-6 7-6 (10-8) triumph.
Seven of Musetti's 12 ATP Tour level wins have now come against players in the top 35 of the rankings.
"The secret for me is not to think about [their ranking], to just play them like other opponents," said Musetti, quoted on the ATP website. "I try to play my game… and try to play as good as I can.
"That is what I did. With them, I always play good. I don't know why. I have no pressure and I feel free. I have no pressure to win and today was the same."
Sixth seed John Millman lost in straight sets to Laslo Djere, but third seed Lorenzo Sonego eased past Gilles Simon 6-4 6-1 to set up a meeting with Yannick Hanfmann, who overcame Marco Cecchinato.
At the Andalucia Open, the seeds tumbled out in Thursday's action.
Second seed Fabio Fognini was thrashed 6-2 6-1 by Jaume Munar, Alejandro Davidovich Fokina lost in straight sets to Ilya Ivashka and sixth seed Feliciano Lopez was undone by a comeback from Carlos Alcaraz.
Seventeen-year-old Alcaraz recovered after losing the first set to beat veteran Lopez 4-6 6-2 6-4. Bucking the trend of the day, third seed Casper Ruud prevailed 6-3 6-2 against Gianluca Mager.
Sinner guides Italy to back-to-back Davis Cup triumphs
Jannik Sinner capped his outstanding year by helping Italy retain the Davis Cup, beating Tallon Griekspoor to ensure Italy downed the Netherlands 2-0 in Sunday's final.
World number one Sinner overcame Griekspoor 7-6 (7-2) 6-2 after Matteo Berrettini had registered a 6-4 6-2 win over Botic van de Zandschulp in the opener.
Sinner saved the only two break points of the first set as Griekspoor put up a fight, but the Italian put on a show in the tie-break to inch ahead.
Griekspoor hit back after giving up an early break in the second set, but Sinner immediately responded with two further breaks, with the Dutchman double-faulting for the first then wildly miscuing with a backhand for the second.
Sinner was untroubled from then on, sealing a triumphant end to a spectacular season.
The Italian has only dropped one set throughout that streak, finishing a year that saw him win the Australian Open, US Open and ATP Finals with a 73-6 singles record.
Data Debrief: Sensational Sinner leads the way
This has been a truly remarkable year for Sinner, who has become the first man in the Open Era to win at least one set in every match throughout a season since Roger Federer in 2005.
His victory ensured Italy became the first team to retain the Davis Cup since the Czech Republic triumphed in 2012 and 2013.
Italy also captured the Billie Jean King Cup earlier this week, and they are just the third nation to claim both trophies in the same season in the last 30 years, after the Czech Republic in 2012 and Russia in 2021.
Sinner and Berrettini send defending champions Italy into Davis Cup final
Jannik Sinner's victory over Alex de Minaur clinched Italy's place in another Davis Cup final, with Matteo Berrettini also victorious as the defending champions beat Australia 2-0.
Italy won the Davis Cup for the first time since 1976 last year, and they will have an opportunity to defend their crown against the Netherlands on Sunday.
Former Wimbledon finalist Berrettini got the ball rolling with an entertaining 6-7 (6-8) 6-3 7-5 victory over Thanasi Kokkinakis, not surrendering a break after losing the opener in a tie-break.
That teed up Sinner to close out Italy's victory, with the world number one overcoming De Minaur 6-3 6-4, the same scoreline he beat the Australian by at the ATP Finals earlier this month.
Speaking after his victory in Malaga, Sinner said: "It means a lot. It was a tough encounter, playing Alex. We know each other quite well now, so I have to be very careful every time.
"It's a very tough challenge for me, so I was looking forward to this one. Obviously, it helped a lot that Matteo won the singles today. He played amazing tennis. It was very high quality.
"Hopefully, this can give us some confidence for [Sunday]. It's going to be a very difficult and tough day for us and also the Netherlands."
Data Debrief: Back-to-back for Italy
Italy's men are looking to follow in the footsteps of their female counterparts, who won the Billie Jean King Cup earlier this week.
They are just the third nation in history to make back-to-back finals at both the Davis Cup and the Federation/Billie Jean King Cup, after the United States (1963-64, 1978-79, 1981-82 and 1990-91) and Australia (1963-64 and 1964-65).
Djokovic appoints Murray as coach for Australian Open
Novak Djokovic has announced his long-term former rival Andy Murray as his coach for the Australian Open in 2025.
Murray, a three-time Grand Slam winner, announced his retirement earlier this year and played his final match at the Paris Olympics in August.
He will join Djokovic's team in the off-season and coach him through the opening grand slam of the year, which begins on January 12.
This will be Murray's first coaching role since retiring following a 19-year career.
"We played each other since we were boys. 25 years of being rivals, of pushing each other beyond our limits," Djokovic said in a video on social media.
"We had some of the most epic battles in our sport. They called us game changers, risk-takers, history makers.
"I thought our story may be over - turns out it has one final chapter.
"It's time for one of my toughest opponents to step into my corner. Welcome onboard coach, Andy Murray."
Djokovic failed to win a major title for the first time since 2017, though he did clinch a long-awaited Olympic gold medal in Paris.
The Serb is currently level with Margaret Court for the most major singles titles by any player. He has a good record in Australia though, winning 10 times in Melbourne, beating Murray in four of those finals.
Murray, who beat Djokovic to win the US Open title in 2012 and Wimbledon the following year, says he hopes they can achieve success together.
"I'm going to be joining Novak's team in the off-season, helping him to prepare for the Australian Open," Murray said.
"I'm really excited for it and looking forward to spending time on the same side of the net as Novak for a change, helping him to achieve his goals."
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