Daniil Medvedev restored order by beating Flavio Cobolli in the US Open evening session, avoiding the same fates as former champions Novak Djokovic and Carlos Alcaraz.
The Russian, who is now the only former champion remaining in the men's field at Flushing Meadows, won 6-3 6-4 6-3 in two hours and 18 minutes.
Though Cobolli fought well, getting the first break in the match early on and valiantly defending set point six times in the first two sets, he could not stage another upset.
Medvedev struck 33 winners as he asserted his dominance and will meet Nuno Borges in the fourth round in New York.
"I said it before the match that for me the upsets don't really matter," Medvedev said.
"The only thing [is when] the conditions are a bit tricky, the favourites maybe have less margin than the other guys. Just have to be more cautious.
"It was a tough match. It was just a little bit up and down, and at one moment I started playing much better on my serve than on his.
"If I play good tennis I can win the whole thing. If I don't play good, I can lose against anyone."
Data Debrief: No upsets here
With two of the favourites for the title already out of the race, Medvedev will feel good about his chances of winning a second US Open title.
This victory was his 138th combined match win on hard court (grand slams and ATP Masters 1000 events), equalling Roger Federer for the second-most of any player on the surface in the past decade, trailing only Novak Djokovic (227).
Medvedev is into the fourth round for the 11th time in the men's singles event at grand slams on hard court - he is the only Russian in the Open era to reach this stage 10+ times.
US Open: Swiatek breezes into fourth round in straight sets
Iga Swiatek cruised into the fourth round of the US Open, crediting a chat with Serena Williams for her straight-sets win over Anastasia Pavlyuchenkova.
The world number one prevailed 6-4 6-2, without facing a break point in Arthur Ashe Stadium on Saturday.
Swiatek needed just 95 minutes to get into the next round, setting up a meeting with Liudmila Samsonova.
A four-game winning streak in the second set put the game beyond doubt, earning her a third straight-sets victory of the tournament so far.
"It was nice that Serena [Williams] approached me [in the players' gym], because I wouldn't, for sure, find courage to do that," Swiatek said.
"Even though we met before and for a couple of years we have been on the same sides and on tour together, she's still star-striking for me.
"It inspired me, and it gave me a positive kick.
"It's not like my tennis is perfect, but it is weird because I have been number one and winning tournaments, I feel I need to work on some stuff."
Data Debrief: Total dominance
Swiatek, who won at Flushing Meadows in 2022, is into the fourth round at a grand slam for just the second time this year, having failed to reach it at the Australian Open and Wimbledon.
It is the 16th time she has reached that stage in her 23rd main draw appearance - only Coco Gauff has also reached the fourth round in over half of her main draws at grand slams among active players.
The Pole looks to be in fine form though, with this victory lifting her winning percentage to 82.8% (82-17) in women's singles matches at grand slam events - she is now up to 11th on the all-time list in the Open Era, surpassing Martina Hingis.
Sinner avoids O'Connell upset at US Open
Jannik Sinner beat Australia's Christopher O'Connell in straight sets to reach the fourth round of the US Open on Saturday, avoiding a similar fate to Carlos Alcaraz and Novak Djokovic.
The men's draw at Flushing Meadows has been blown wide open by early exits for Alcaraz and Djokovic, but the top seed remains in the hunt after a composed performance.
He reached the fourth round for a fourth consecutive year with a routine 6-1 6-4 6-2 victory, setting the tone with several huge groundstrokes in the opening set.
O'Connell never looked likely to fight back as Sinner smashed 46 winners in a ruthless performance, wrapping up his win in one hour and 56 minutes.
The Australian Open champion will face either Tommy Paul or Gabriel Diallo for a place in the last eight, and he was relieved to survive an opening week full of surprises.
"Everything can happen in this sport, so I try to stay on my side of the net and I'm trying to take the tournament day by day," Sinner said in his on-court interview after the win.
"Each opponent is a very tough challenge and [I am] also enjoying every moment on the court. There have been already a couple of upsets, so let's see what's coming.
"But I'm very happy to still be here and hopefully I can play as many matches as possible. But as I said, we go day by day and then we'll see how it goes."
Data Debrief: Sinner heating up
Sinner lost his first set of the tournament to Mackenzie McDonald but has been largely untouchable since then.
He has only lost 18 games across his last nine sets of tennis, an average of two per set.
The Italian's winning streak now stands at seven straight matches, meanwhile, following his triumphant Cincinnati Open run.
US Open: Sabalenka overcomes first set scare to progress in late start
Aryna Sabalenka came from a set down to keep her US Open dream alive as she beat Ekaterina Alexandrova in the early hours at Flushing Meadows.
Sabalenka emerged on court at the Arthur Ashe Stadium at seven minutes past midnight following Novak Djokovic's shock exit from the tournament, and consecutive upsets looked to be on the cards.
However, the Belarusian responded from a disappointing opening set as she looks to avenge her defeat in the showpiece match against Coco Gauff a year ago.
The world number two set up a meeting with Belgium's Elise Mertens as she emerged a 2-6 6-1 6-2 victor in one hour and 40 minutes in New York.
"I don't know what I did, I was just trying to stay low, put as many balls as I can back on that side," Sabalenka said.
"She played incredible tennis in the first set. It was really tough to change it."
"I'm really happy I was able to turn around this match and get this really difficult win. Thanks so much for staying that late."
Data Debrief: Sabalenka survives late, late show
Sabalenka's encounter with Alexandrova was the latest starting match at the US Open, beating Gabriela Sabatini and Beverley Bowes' meeting in 1987 that started at midnight.
The Belarusian, however, will be hoping for a much improved performance in the next round, having produced 27 unforced errors throughout the contest and serving four double faults.
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