Daniil Medvedev restored order by beating Flavio Cobolli in the US Open evening session, avoiding the same fates as former champions Novak Djokovic and Carlos Alcaraz.
The Russian, who is now the only former champion remaining in the men's field at Flushing Meadows, won 6-3 6-4 6-3 in two hours and 18 minutes.
Though Cobolli fought well, getting the first break in the match early on and valiantly defending set point six times in the first two sets, he could not stage another upset.
Medvedev struck 33 winners as he asserted his dominance and will meet Nuno Borges in the fourth round in New York.
"I said it before the match that for me the upsets don't really matter," Medvedev said.
"The only thing [is when] the conditions are a bit tricky, the favourites maybe have less margin than the other guys. Just have to be more cautious.
"It was a tough match. It was just a little bit up and down, and at one moment I started playing much better on my serve than on his.
"If I play good tennis I can win the whole thing. If I don't play good, I can lose against anyone."
Data Debrief: No upsets here
With two of the favourites for the title already out of the race, Medvedev will feel good about his chances of winning a second US Open title.
This victory was his 138th combined match win on hard court (grand slams and ATP Masters 1000 events), equalling Roger Federer for the second-most of any player on the surface in the past decade, trailing only Novak Djokovic (227).
Medvedev is into the fourth round for the 11th time in the men's singles event at grand slams on hard court - he is the only Russian in the Open era to reach this stage 10+ times.
Djokovic recovers from slow start to move past Michelsen on Shanghai return
Novak Djokovic marked his Shanghai Masters return with a hard-fought straight-sets win over Alex Michelsen.
The four-time champion, who is appearing in this event for the first time since 2019, required two tie-breaks before prevailing 7-6 (7-3) 7-6 (11-9) in just under two hours.
Djokovic, still donning a protective sleeve over his right knee, made a slow start in only his second match since losing to Alexei Popyrin in the US Open third round, winning just four points in the first three games as he fell 4-1 behind.
However, the 24-time major winner broke back in the seventh game before dominating the tie-break for first blood.
Roles were reversed in the second set as Michelsen cancelled out an earlier break in game seven.
However, the American squandered two set points to level and was eventually punished by Djokovic, who will play either 28th seed Flavio Cobolli or three-time major winner Stan Wawrinka in the next round.
Data Debrief: Djokovic continues American dominance
Djokovic was given an early scare, but his experience eventually showed as he came through.
Including team events, the Serb has now won his last 33 ATP-level matches against American opponents, with his last such defeat coming against Sam Querrey at Wimbledon in 2016.
The 24-time major winner also demonstrated his determination when the pressure intensified, and he has now come through 12 of his 16 tie-breaks played this season.
Gauff fights back to beat Badosa in China Open semi-finals
Coco Gauff recovered from a set and a break down to reach the China Open final with a 4-6 6-4 6-2 victory over Paula Badosa on Saturday.
Having given up an early break in the opener, Gauff got one of her own by converting her eighth break point in a mammoth eighth game featuring 10 deuces, only for Badosa to hit back immediately to go a set up.
Gauff lost serve immediately in the second set to go on the back foot, only to level the match with back-to-back breaks, the second of them to love.
The decider began with a series of breaks, Gauff taking two of them as the momentum swung her way, then she protected her lead all the way to reach her first final since winning January's Auckland Open.
The 20-year-old is the youngest player to reach the women's singles final at the China Open since Caroline Wozniacki in 2010.
She has fought from a set down to win in each of her last three matches, the first time she has done so in her career. She is the first player to do so in WTA-1000 events since Iga Swiatek at Indian Wells 2022.
Data Debrief: Gauff brings up century
Saturday's match was Gauff's 100th at WTA 1000-level events, and her 67th such victory.
Among American players, only Serena Williams (87), Venus Williams and Jessica Pegula (70) have bettered her 67 wins through their first 100 matches at such events.
Sinner reaches 250 career wins after seeing off Daniel in Shanghai opener
Jannik Sinner notched up his 250th career win after defeating Taro Daniel in his Shanghai Masters opener.
The world number one wrapped up a commanding 6-1 6-4 victory over his Japanese opponent in just over an hour-and-a-quarter on Saturday.
Sinner, who is fresh from reaching the Beijing final last time out, is targeting his seventh silverware of the season, in which he has already triumphed at the Australian Open and US Open.
"I felt quite comfortable today," said the Italian, who set up a clash with 31st seed Tomas Etcheverry. "I also feel in good shape physically, which is very important for me.
"Of course, I will try to improve for tomorrow's performance, but today I was serving really, really well - especially in important moments - and was moving well."
Data Debrief: 250 up for Sinner
Sinner became the first player born in the 2000s to reach 250 career wins, while taking his tally for a remarkable campaign to 60.
The Italian, who won 64 matches last term, is the sixth player aged 23 or under to record 60 or more ATP wins in successive seasons, after Lleyton Hewitt, Andy Roddick, Roger Federer, Rafael Nadal and Novak Djokovic.
Sinner also maintained his perfect record in opening-round matches this year (14-0), and is now 51-0 against players ranked outside the ATP top 20.
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