Wimbledon champion Elena Rybakina pulled out of the French Open ahead of her third-round match because of illness.
The fourth seed was one of the favourites for the title having enjoyed a brilliant season and won the Italian Open in Rome last month.
She won both her first two matches comfortably against teenagers Brenda Fruhvirtova and Linda Noskova but withdrew minutes before she was due to take to Philippe Chatrier to face Sara Sorribes Tormo.
Rybakina said: “I was not feeling good already yesterday and the day before, so I didn’t sleep two nights and had some fever. Today I really tried in the warm-up but I feel that the right decision is to withdraw, because it’s really tough to play with these conditions.
“I saw the doctor and they said that actually it’s all a virus here in Paris. I guess with my allergy, immune system just went down and I picked up something. It’s difficult to perform and obviously to run and even breathe. So I think that was the only right decision I could make.
“Today I just wanted to give 100 per cent and obviously I’m far from being 100 per cent. It was unlucky for me. I just try to recover and do my best to be prepared for the grass season already.”
The timing is hugely unfortunate for the 23-year-old, who has established herself at the top of the tree in women’s tennis alongside Aryna Sabalenka and Iga Swiatek and was seeded to meet the Pole in the semi-finals.
“Of course I’m really upset not to be able to play but I guess that’s life,” added the Kazakhstan player. “There is a lot of ups and downs.”
Rybakina is due to play her first grass-court tournament in Berlin beginning on June 19 before heading to Eastbourne as she builds up to the defence of her Wimbledon title.
ATP Finals: Zverev targets 10 more years at the top after Ruud win
Alexander Zverev outlined his plan to stay at the top of the game for another decade after overcoming Casper Ruud in his second match at the ATP Finals.
Having started his campaign at the season finale in Turin by downing Andrey Rublev, Zverev made it two wins from as many matches with a 7-6 (7-3) 6-3 victory over the Norwegian.
He needed just 86 minutes to wrap up his victory, hitting 28 winners to his opponent's 13 in a confident, powerful performance.
Zverev is appearing at the ATP Finals for a seventh time, and another victory over Carlos Alcaraz on Friday would secure his spot in the semi-finals.
The German has won the event on two previous occasions, beating Novak Djokovic in the 2018 showpiece and overcoming Daniil Medvedev in 2021.
Asked what his experience at the ATP Finals meant for his chances of success, he joked: "It means I'm old! But I still don’t feel old.
"I hope I have another solid 10 years ahead of me, but I think it’s a young group of guys.
"There has been kind of a shift in tennis this year and I think it's a good thing. They're exciting new players and everybody loves watching them."
Data Debrief: ATP Finals specialist marches on
Since the ATP Finals moved to Turin for the 2021 event, Zverev's eight victories at the competition have only been bettered by Djokovic's 12.
Meanwhile, the German has also managed more ATP Tour-level wins this year than any other player, with Wednesday's success his 68th of 2024.
ATP Finals: Alcaraz 'surprised' himself with battling Rublev victory
Carlos Alcaraz surprised himself with the level of performance he was able to produce in his win over Andrey Rublev at the ATP Finals on Tuesday.
Alcaraz emerged a 6-3 7-6 (10-8) victor against the Russian in his second match of the tournament, keeping his hopes of advancing to the next round in Turin alive.
The Spaniard fell to defeat in his opening game against Casper Ruud, citing a stomach issue that left him feeling unwell before and during that match.
But the world number three looked back to his brilliant best against Rublev, claiming the first set in 37 minutes before edging a thrilling tie-break in the second.
"Yes, I surprised myself a lot," Alcaraz said shortly after the victory.
"The way I played today from the baseline, I was really calm and tried to just focus on my game and what I had to do - forget that I'm not really feeling well.
"Once you step on the court, you have to forget everything you're struggling with outside the court."
Alcaraz, though, said he was still not feeling 100% ahead of facing Alexander Zverev, who is in action against Ruud later on Tuesday.
It will be the pair's first meeting since the Spaniard's triumph in the French Open final in June, but Zverev has not let that defeat ruin a fine season.
His own opening win over Rublev was his ATP Tour-leading 67th win of the campaign, with only Jannik Sinner matching the German for victories this year.
"I could be better, healthier. I'm just trying to step on the court and play good tennis, try not to think about my issues right now," Alcaraz said.
"I've been struggling the last week and that's going to be the case over the next day too, for sure.
"Zverev is playing great tennis. He is one of the toughest players in the world right now, that's for sure.
"I will try to play good tennis and enjoy the same way I did today. Then let's see."
ATP Finals: Alcaraz overcomes illness to edge Rublev in Turin
Carlos Alcaraz overcame his recent illness to keep his hopes of progressing at the ATP Finals alive with a straight-sets triumph over Andrey Rublev on Tuesday.
Alcaraz had complained about feeling unwell in his defeat to Casper Ruud, but returned to winning ways with a 6-3 7-6 (10-8) victory in 96 minutes against his Russian opponent.
The Spaniard, sporting a pink nasal strip to aid his breathing, exchanged blows with Rublev early on but was able to take control of the encounter after the fifth game.
Alcaraz reeled off four consecutive games from 3-2 down to seal the opening set, closing in on a second consecutive win against Rublev at the year-end tournament in Turin.
The enthralling affair continued to produce some sensational tennis, most notably when Alcaraz brilliantly turned defence into attack during a long rally in the third game.
The four-time grand slam champion later kept his cool in the second-set tie-break, saving two set points before closing out the win to kickstart his campaign.
Alcaraz now sits at the top of the John Newcombe Group ahead of Alexander Zverev's meeting with Ruud later on Tuesday, with the German up next for the world number three.
Data Debrief: Winning the best medicine
After a rocky start to his ATP Finals campaign, Alcaraz's latest showing confirmed that, despite not feeling at his best, he can still pose a threat at the tournament.
The Spaniard struck 31 winners compared to Rublev's 14, but did match his opponent for unforced errors during the contest (20 each).
But it was another victory on a favoured surface for the world number three. Since the ATP rankings were first published in 1973, Alcaraz (21 years and 192 days) is the second-youngest player to claim 20 top-10 wins on hard courts, older only than Lleyton Hewitt.
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