Taylor Fritz and Alexander Zverev were sent packing from the Australian Open as wildcard Alexei Popyrin and lucky loser Michael Mmoh sprang major shocks.
Australian Popyrin said he was living a dream after beating the fancied Fritz in an epic second-round match lasting four hours and two minutes on John Cain Arena.
American Mmoh, whose mother has Australian citizenship, knocked out former world number two Zverev just moments later on Margaret Court Arena.
Their exits followed the shock defeat for second seed Casper Ruud earlier in the day, as Novak Djokovic's half of the draw lost a host of big names.
Wildcard Popyrin won 6-7 (4-7) 7-6 (7-2) 6-4 6-7 (6-8) 6-2 against American eighth seed Fritz, revelling in the chants of "Popy" from the crowd afterwards.
The 23-year-old was close to tears, his voice breaking, after reaching the third round of a grand slam for the fifth time.
"This win, it means so much to me," Popyrin said. "I had the toughest year last year, didn't win many matches. I've won as many matches this year as I won in the whole of last year, and it's only January.
"Pre-season I put my head down and worked as hard as I could. I don't want that feeling I had last year ever again.
"I wrote that down to myself in my head, and I'm going to keep working, I'm going to keep pushing, I'm going to keep trying to go all the way."
Addressing the crowd, Popyrin added: "I love this feeling. I want more of this feeling. I want you guys to have this feeling more. I love you guys so much, thank you."
He is coached by former top-20 star Xavier Malisse and felt the Belgian's influence against Fritz.
"I was playing four hours, and me and my coach were locked in, it was like two against one against Fritzy. We had the same thoughts all the time," Popyrin said. "This is the dream for me and I don't want to wake up at all."
Mmoh was beaten by Aleksandar Vukic in the final round of qualifying but received a call into the draw at the last minute, after a late withdrawal, allowing him to cancel a flight home.
The world number 109 will face fellow American JJ Wolf next, for a place in round four, having ousted 12th seed Zverev 6-7 (1-7) 6-4 6-3 6-2.
Mmoh's father, Tony, represented Nigeria and won a match at the Australian Open in 1988.
"Life is crazy," Mmoh said. "Right when you think everything is looking dim, everything is looking dark, there's light at the end of the tunnel.
"My week is proof of that. I could easily have been in the States, was ready to be in the States, had my bag packed, my flight booked, I was meant to leave yesterday morning. The fact I'm playing Margaret Court is insane.
"If you look at my box over there, there's about five to seven Aussies. I used to come every single Christmas to visit them, unfortunately my mum couldn't be here, I feel like I'm half Australian because of them and I love you guys. This is like my second home now so might as well make it a homecoming.
"It's the biggest win of my career hands down. Coming out I felt the nerves a little bit. I settled down at the end of the first, and at that point I told myself I shouldn't even be here. I told myself on match point if I get a chance just go for it, because I shouldn't even be here."