Naomi Osaka began the defence of her Pan Pacific Open crown with a quick win after opponent Daria Saville was forced to retire in just the second game.
Four-time grand slam champion Osaka won the opening game, before Saville was unable to continue due to a scary-looking injury to her left knee.
The former world number one will now face a second round match with world number 16 Beatriz Haddad Maia, who eased to a straight sets victory over Yuki Naito.
Karolina Pliskova secured her place in the next round in Tokyo with a 6-2 6-1 demolition of Isabella Shinikova, while Zhang Shuai will face second seed Caroline Garcia on Wednesday after overcoming Mai Hontama in two sets.
In Seoul, Jelena Ostapenko's hopes of repeating her 2017 heroics at the Korea Open are still alive after the number one seed narrowly beat 19-year-old Jeong Bo-young.
The world number 19 looked to be cruising after the opening set, but the unheralded South Korean hit back in the second and took it to a tie-break in the third, before Ostapenko's class showed as she won the crucial tie-break 7-2.
Elsewhere, 2021's beaten finalist Kristina Mladenovic saw off wildcard Park So-hyun 6-4 4-6 6-3, while second seed Ekaterina Alexandrova overcame a worrying second set to beat Asia Muhammad 6-1 3-6 6-1.
Wimbledon semi-finalist Tatjana Maria is also safely through to the second round after a tight 7-6 (7-5) 7-6 (7-5) triumph over Eugenie Bouchard.
Safiullin triumph 'very close to a 10', insists Djokovic
Novak Djokovic believed his straight-set triumph against Roman Safiullin at the Shanghai Masters was almost perfect, while reiterating his desire to compete at the very top.
Djokovic, featuring in his first tournament since his shock US Open exit, was largely untroubled in a 6-3 6-2 win against the Russian on Wednesday.
The world number four's triumph also saw him become the first player to reach 10 quarter-finals at the tournament in Shanghai, claiming his 37th victory in the process.
Djokovic is on a quest to claim his 100th ATP tour title, hoping to join the elite club that includes only Jimmy Connor and Roger Federer who have reached that milestone.
The Serbian had already beaten Alex Michelsen and Flavio Cobolli to reach the round of 16, and will face Czech teenager Jakub Mensik for a place in the final four.
And the 24-time grand slam champion said his tennis at the tournament so far is bringing him "a lot of joy".
"Very close to 10. The [past two matches] are some of the best matches I've played in a while," Djokovic said.
"I'm enjoying myself on the court and when you play well you are feeling good, there is a lot of joy in striking a tennis ball.
"These matches and sensations are the reasons why I still play.
"I believe I can play at a high level and it's about keeping that consistency.”
Goffin produces Zverev upset to reach Shanghai quarters
David Goffin produced a vintage display to down second seed Alexander Zverev and book his place in the quarter-finals at the Shanghai Masters on Wednesday.
Goffin, who has now reached the last eight of an ATP Masters 1000 event for the first time since 2021, emerged a 6-4 7-5 victor in just under two hours.
The Belgian was the first to take an early grip of the contest, finally managing a break point at the third time of asking in the third game, only for Zverev to respond straight after.
But Goffin was able to find another break of serve, with the world number 66 closing out the first set with a love game to take a surprise lead.
Despite Zverev starting with a love game of his own in the second, the German quickly found himself 3-1 down as Goffin threatened to run away with the tie.
However, the second seed clawed his way back into the contest, levelling the score, but Goffin remained composed, sealing the victory with another love game.
Goffin will face seventh seed Taylor Fritz for a spot in the final four in Shanghai after the American swept aside Holger Rune 6-1 6-2 in just 55 minutes earlier in the day.
Data Debrief: Goffin joins elite club
Goffin has become only the second player to defeat Zverev head-to-head on hard, grass and clay courts at ATP level, along with Roger Federer.
With the Belgian, who is the 66th ranked player in the world, and Jakub Mensik, who is one place above, now through, it is the first time multiple players ranked outside the ATP's top 50 have made the quarter-finals at the Shanghai Masters since the event's inauguration in 2009.
Djokovic marches into 10th Shanghai quarter-final
Novak Djokovic saw off Roman Safiullin to reach his 10th Shanghai Masters quarter-final with a straight-sets win on Wednesday.
The Serb, a four-time champion in the tournament, rallied to a 6-3 6-2 victory in just 74 minutes.
Djokovic made a lightning-quick start, serving to love to win the opening game, but had to remain patient as he waited for an opening, which he found with a three-game winning streak at the end of the first set.
Any hopes Safiullin had of a comeback were then squashed as he saw his serve broken first in the second.
Djokovic was clinical from that point, defending a break point – his third in the match – before claiming another break on his way to a comfortable victory.
As his hunt for a 100th tour-level title goes on, Jakub Mensik now stands between Djokovic and a place in the last four.
Data Debrief: Djokovic continues Shanghai dominance
At his 95th at ATP Masters 1000 events overall, Djokovic has become the first player to reach 10 quarter-finals at the Shanghai Masters, since its inauguration in 2009.
It was also his 37th win at the tournament, extending his own record as he keeps the title in his sights.
If he can get his hands on the trophy, he would be just the third man to win 100 tour-level titles in the Open Era (after Jimmy Connors and Roger Federer).
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