US Open boss Stacey Allaster said it was "very unfortunate" that Novak Djokovic would have to miss the upcoming grand slam.
Shortly before the draw announcement, it was confirmed that three-time Flushing Meadows champion Djokovic would be absent.
His stance on refusing a COVID-19 vaccination meant he would be prevented from entering the United States, denying the 35-year-old another shot at glory in New York.
Tournament director Allaster said: "Novak is a great champion and it is very unfortunate that he will be unable to compete at the 2022 US Open, as he is unable to enter the country due to the federal government's vaccination policy for non-US citizens.
"We look forward to welcoming Novak back at the 2023 US Open."
The tournament begins on Monday, with Russian Daniil Medvedev defending the title he secured by beating Djokovic in last year's final, when entry requirements to the US were not so restrictive.
Serbian Djokovic has won 21 grand slam titles, one fewer than Rafael Nadal who has already arrived in the Big Apple ahead of the final major of the year.
Nadal moved ahead of Djokovic and clear at the top of the men's all-time list by winning the Australian Open and French Open titles this year, before having to withdraw from a Wimbledon semi-final against Nick Kyrgios because of an abdominal tear.
Djokovic was not allowed to play at the Australian Open at the start of the year, when issues surrounding his visa ended with him being deported from Melbourne on public health grounds due to not taking the vaccine.
Alcaraz's pursuit for third straight Madrid Open crown continues by defeating Seyboth Wild
Carlos Alcaraz boosted his hopes of a third straight Madrid Open title as he comfortably beat Thiago Seyboth Wild to reach the fourth round on Sunday.
Back in his home country of Spain, Alcaraz eased to a 6-3 6-3 triumph to set up a fourth-round clash with Jan-Lennard Struff, whom he beat in last year's final.
The first six games of the opening set went to serve, but Alcaraz found a crucial break in the seventh and ninth games of the set to put him in pole position for victory, a lead he would not relinquish as he overcame being broken in the seventh game of the second set to seal his safe progression.
Holger Rune was a surprise casualty as the world number 12 was defeated 6-4 4-6 6-3 by Tallon Griekspoor, though world number eight Andrey Rublev eased through with a straight-sets win over Alejandro Davidovich Fokina.
Data debrief
With his triumph over Seyboth Wild at the Madrid Open, Alcaraz has now won 93.3 per cent of his games at the tournament. That is the highest win percentage of any player with at least 10 games played in a single ATP-1000 event since the format was introduced in 1990.
Against Seyboth Wild, Alcaraz won 27 of his 31 first-serve points, also recording 19 winners to his opponent's 10 as he dominated the contest on his way to victory.
Rybakina eases past Sherif to reach Madrid Open last 16
Elena Rybakina cruised past Mayar Sherif in straight sets to reach the last 16 of the Madrid Open on Sunday.
World number four Rybakina rarely looked like being troubled by Sherif, easing to a 6-1 6-4 triumph, winning 22 of her 26 first-serve points on her way to victory.
The 2022 Wimbledon champion broke Sherif's serve twice in the first set to gain control of the match, before holding her serve five times in the second to ensure victory.
Also into the last 16 in Madrid are Yulia Putintseva and Daria Kasatkina, who beat Caroline Dolehide and Anastasia Pavlyuchenkova respectively, both in straight sets. However, world number seven and reigning Wimbledon champion Marketa Vondrousova is out after she was upset by Mirra Andreeva, losing 7-5 6-1.
Data debrief
In reaching the Madrid Open last 16, Rybakina again showed her class on clay. Her victory over Sherif saw her become only the fourth player in the last 10 years to win 14 straight WTA matches on clay, alongside Serena Williams, Simona Halep and Iga Swiatek.
Additionally, Rybakina's 475 winners at WTA-1000 events in 2024 are 112 more than the next best, Danielle Collins with 363.
Madrid Open: Nadal roars to victory against De Minaur
Rafael Nadal delighted his home fans at the Madrid Open as he roared to an impressive victory over Alex de Minaur on Saturday.
The Spaniard battled to a 7-6 (8-6) 6-3 victory to earn his first win over a top-20 player in the world rankings since the ATP Finals back in 2022.
De Minaur had beaten Nadal last week in Barcelona, but the five-time Madrid champion was not to be denied this time in front of a crowd which included King Felipe VI along with football stars Zinedine Zidane and Vinicius Jr.
Emerging triumphant from an epic 77-minute opening set proved decisive, with Nadal more comfortable in the second as De Minaur missed an opportunity to become the first player to beat him in consecutive weeks since Novak Djokovic achieved the feat way back in 2011.
Nadal will take on Pedro Cachin in the third round after the Argentine dumped out Fances Tiafoe in three sets.
"I'm super happy to be able to be competitive against a great player like Alex and play over two hours," Nadal said, per the ATP Tour website.
"It means a lot to me and the atmosphere here is just a joke, so I can't thank enough everybody here.
"It still needs time [until I am back to my best]. I think for moments it has been a good level of tennis. I was able to do positive things, but still on and off.
"But I really believe that tennis hasn't been an issue for the last two years. More the physical issues.
"If I am able to play weeks in a row and if I am able to play tennis, then I'm going to see how far I can go and how competitive I could be. But that's not the case yet, just step by step and let's see how I recover."
Elsewhere at the tournament, Australian Open champion Jannik Sinner, playing as the top seed at a Masters 1000 event for the first time, cruised to victory over fellow Italian Lorenzo Sonego to start his campaign in style.
It took Sinner just 69 minutes to win 6-0 6-3 and improve to 26-2 in a remarkable 2024 season so far.
“I know Lorenzo quite well and we have a good friendship off the court, we play Davis Cup together, we practise a lot together,” Sinner said.
“The mental side was a little bit different than it used to be, so I'm just happy how I handled the situation. He didn't play at his best. I think we saw this. I wish him all the best for the rest of the season.”
Progress was harder to come by for Daniil Medvedev as he lost the opening set to Matteo Arnaldi, though the third seed eventually battled through 2-6 6-4 6-4 to book a third-round clash with American Sebastian Korda.
There was a surprise result, though, with Brazilian qualifier Thiago Monteiro ending the fine recent form of Stefanos Tsitsipas with a 6-4 6-4 victory.
Tsitsipas was 10-1 on clay this year going into the match, but the sixth seed crashed to a shock defeat just a week after Monteiro had lost in the first round of a Challenger Tour event in Portugal, marking a rapid reversal of his fortunes.
“Every week you have a new opportunity," said Monteiro. “These past few weeks I wasn’t feeling really good on the court. I was trying to do well at Challengers but it didn’t work.
“I just kept up the hard work, day by day. Even when I was not feeling good and not winning matches, I kept believing in myself, and this week it has paid off.
"For sure one of the biggest wins of my career. I knew it was a really tough match and I tried to just believe in myself all the time."
Sunday’s matches will see Nadal’s compatriot Carlos Alcaraz continue his campaign with a third-round clash against Thiago Seyboth Wild.
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