Last week's Masters champion Jon Rahm shook off his poor opening round and rebounded with Friday's best score, while Jimmy Walker opened up a three-stroke lead at the RBC Heritage.
Rahm had a bit of a hangover following his second major victory, beginning his week at Harbour Town Golf Links with a one-over 72, before showing the field how it was done with a seven-under 64 on his second trip around the course.
He birdied holes two, three, four and five to kick-start a bogey-free round with seven birdies overall, jumping from the wrong side of the cut line to a tie for 18th at six under.
Meanwhile, at the top of the leaderboard it was Jimmy Walker who raced clear of the pack, posting his second 65 in a row to head into the weekend at 12 under.
Walker, 44, is a six-time winner on the PGA Tour, but his last victory came at the 2016 PGA Championship, and he came into this event with only four made cuts from 12 starts this season.
He has his work cut out for him to hold off a star-studded chasing pack, with world number two Scottie Scheffler joined by major champion Justin Rose and world number six Xander Schauffele at nine under.
Fellow top-10 talents Patrick Cantlay and Viktor Hovland are one stroke further back at eight under, where they are joined by English duo Aaron Rai and Tommy Fleetwood in a tie for fifth.
Jordan Spieth is tied for 10th at seven under with a group that includes Rickie Fowler and former RBC Heritage champion Matt Kuchar, and Rahm is joined at six under by reigning U.S. Open champion Matt Fitzpatrick.
Young South Korean phenom Tim Kim missed the cut by one stroke, while Max Homa had a week to forget, finishing at three over to miss the cut by five strokes.
Scheffler swinging with confidence at Tour Championship despite seeing lead cut to four
Scottie Scheffler insists his swing is "in a good spot" despite seeing his lead at the top of the Tour Championship standings cut to four shots on the second day.
Scheffler, who is aiming to win his first FedEx Cup title, carded 65 in his opening round and entered the second round with a 10-shot lead.
However, the world number one saw American duo Collin Morikawa and Xander Schauffele close the gap during a weather-disrupted second round on Friday.
Scheffler carded a round of 66 to take himself to 21 under par, aided by two birdies in the final three holes to keep the chasing back at bay.
"I feel like my swing is in a good spot, and I've hit it nice the last couple of days," he said. "A lot of quality stuff out there, and in a good spot going into the weekend."
Morikawa is four shots off the pace after producing a superb eight-under 63, which was the best round of the day, and has surged up the standings to second place.
In an impressive round, he dropped just one shot on the 11th hole, but made amends on the back nine before closing with back-to-back birdies.
"He's going to continue to make birdies," Morikawa said about the possibility of catching Scheffler. "He's driving it really, really well here, and you're giving yourself enough wedges to make some scoring opportunities out there.
"For me, it's just about bringing energy and just staying alive out there."
Schauffele is in third, one shot behind compatriot Morikawa, after shooting an impressive second-round 64 to remain in the hunt for the $25million prize money.
There is then a four-shot gap until a group of three players, including Adam Scott, are tied for fourth place at 12 under, while Rory McIlroy is tied for 10th place on eight under.
'Still feel like I've got a chance', says McIlroy as Scheffler takes Tour Championship lead
Scottie Scheffler is in prime position to win his first FedEx Cup title after storming into a seven-shot lead at the Tour Championship.
The world number one, who started on 10 under due to the FedEx Cup's staggered structure, carded a superb 65 in the first round of the PGA Tour's season-ending tournament, after recovering from an early bogey at East Lake.
Scheffler's haul included seven birdies, with five of those coming from his last seven holes, as he bids to win a seventh PGA Tour event of the season.
His main FedEx Cup challenger Xander Schauffele is tied for second on nine under par, along with Collin Morikawa, while Rory McIlroy is three shots back in T10.
However, the Northern Irishman has not given up hope of applying pressure to Scheffler as the tournament goes on.
"I'm happy with how I hung in there and had a good finish," McIlroy told Sky Sports.
"When I saw Scottie had gotten to 14, I was like, 'Oh, got to try to just hang on to the coattails a little bit'.
"Still feel like I've got a chance, and it was nice to finish the way I did."
Scheffler, also speaking to Sky Sports, said: "Yeah, I'm pleased with the day.
"I tried not to think about any sort of lead or anything like that, my job was to go out there and execute and I felt like I did a really good job of that. I felt like I was doing some good stuff to start the day.
"I had the bogey on one but after that I felt like I played some really good golf."
Bradley in disbelief after moving into FedEx Cup contention with BMW Championship win
Keegan Bradley was in disbelief after putting himself in FedEx Cup contention by winning his second BMW Championship title on Sunday.
Bradley, who was appointed as the United States' 2025 Ryder Cup captain last month, edged out Adam Scott to claim a one-shot victory at the event near Denver.
Scott pulled level with Bradley at the start of his final round but later bogeyed three straight holes as the American won his seventh PGA Tour title.
Bradley, who also won the 2018 tournament by beating Justin Rose in a play-off, now sits fourth in the FedEx Cup standings, behind Scottie Scheffler, Xander Schauffele and Hideki Matsuyama.
Following his victory, the 38-year-old set his sights on another triumph at next week's Tour Championship in Atlanta, having only just squeezed into the 50-player field at Castle Pines.
"Oh, man, it just shows why you've got to grind it out every week because you never know how fast it can switch," Bradley said.
"Now I go to Atlanta with a chance to win the FedEx Cup. I can't believe it. I'm so excited.
"I'm in a bit of a state of shock because there was a time a week ago about this time that I didn't think I was going to be coming here.
"I had to have a lot of magical things happen for me to just play in this tournament, and when I got here, I was so grateful just to be here.
"I played with a real sense of calm all week, which is not the norm for me"
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