The Denver Nuggets have been dealt a blow after star guard Jamal Murray suffered a torn anterior cruciate ligament (ACL) of the left knee.

Murray will be sidelined indefinitely after the high-flying Nuggets revealed the injury diagnosis on Tuesday.

Denver were left sweating over Murray's fitness following Monday's 116-107 NBA loss to the Golden State Warriors.

Murray fell to the floor in agony following an apparent non-contact injury – the 24-year-old clutching his left knee amid serious concerns on court.

Denver's Murray has been averaging a career-high 21.2 points, 4.0 rebounds and 4.8 assists per game this season.

Murray has also been boasting career highs in field-goal percentage (47.7) and three-point percentage (40.8).

The Nuggets (34-20) – led by MVP candidate Nikola Jokic – are fourth in the Western Conference.