Eddie Jones says Joe Marler's decision to withdraw from England's Six Nations squad does not mean his Test career is over.

Marler on Monday revealed he has opted against playing in the upcoming tournament so he can remain with his family during the coronavirus pandemic.

He tweeted: "Always grateful for the opportunity so not an easy decision, but want to do right by my family in these crazy times and won't be meeting up with the squad for this tournament. Look forward to watching the team rip in. Go well."

Marler announced his international retirement in 2018 in order to spend more time with his family but has gone on to take his tally of caps to 72 after reversing that decision.

England head coach Jones said the 30-year-old Harlequins prop, who also made himself unavailable for the tour of Australia in 2016 as he needed a rest, will be considered when he is ready to play for his country again.

"Joe has made a decision that we 100 per cent support," Jones said at the 2021 virtual Six Nations launch.

"When he decides to make himself available again we will have another look at selection. And that's how we look at it - 100 per cent. No ifs or buts, it's as clear as day.

"There will be some time in the future when he's ready to come back and will get selected. We'll take that when it comes.

"Joe has been an outstanding player during my time with England and I'm sure he was outstanding before that.

"He is tough, abrasive, a good defender, a great guy off the field. He's a bit nutty, but we like that, it's good to have characters like that in the squad."

England have also lost Sam Underhill (hip) and Joe Launchbury (fibula stress fracture) for the defence of their title, which they start against Scotland at Twickenham a week on Saturday.

Sam Underhill is the latest player to withdraw from England's Six Nations squad due to a hip injury.

Jack Willis has been called up as a replacement for back-row Underhill, who is another big loss for the defending champions.

Underhill played a big part in England's Six Nations and Autumn Nations Cup triumphs last year but sustained an injury blow before he was due to link up with the squad at St. George's Park on Wednesday.

Willis made his Test debut against Georgia last November and will be hoping to make his Six Nations bow in the coming weeks.

Underhill's withdrawal comes a day after Joe Launchbury and Joe Marler were ruled out due to a fibula stress fracture and personal reasons respectively.

England head coach Eddie Jones' preparations had already been disrupted last week when he was forced to go into self-isolation after his assistant Matt Proudfoot tested positive for coronavirus.

The Red Rose start the defence of their title against Scotland at Twickenham a week on Saturday.

Wasps back Paolo Odogwu and Bristol scrum-half Harry Randall have won their first England call-ups for the Six Nations.

Bath prop Beno Obano is the third uncapped player to be named by Eddie Jones in the 28-man squad.

Courtney Lawes returns from injury, while Mako Vunipola, who last played in the Autumn Nations Cup final win over France, will join the squad for rehabilitation but be unavailable for selection.

Wasps flanker Jack Willis and Bath's Jonathan Joseph only make the 12-man shadow squad, while Kyle Sinckler, who is banned for the opening game against Scotland on February 6, is not in either group.

Owen Farrell will retain his position as captain.

The squad will meet up at St. George's Park on January 27, with coach Jones, who is isolating after assistant Matt Proudfoot tested positive for coronavirus, set to arrive a day later.

"This has been a really tough squad to pick and I know there are a lot of disappointed players who haven't been selected," said Jones.

"We're really excited by the players we have got, it's a very vibrant squad and are looking forward to getting started next week.

"We're very grateful to the Premiership Rugby, the clubs and RPA [Rugby Players Association] for allowing us to have 28 players throughout the tournament, we're very happy with the number and it's testament to the growing relationships between all parties.

"Ultimately our goal is to win the Six Nations and to do that we'll need to work hard and prepare well each day and take it as it comes."

England squad:

Forwards: Luke Cowan-Dickie, Tom Curry, Ben Earl, Ellis Genge, Jamie George, Jonny Hill, Maro Itoje, Joe Launchbury, Courtney Lawes, Joe Marler, Beno Obano, Will Stuart, Sam Underhill, Billy Vunipola, Harry Williams, Mark Wilson.

Backs: Elliot Daly, Owen Farrell, George Ford, Ollie Lawrence, Max Malins, Jonny May, Paolo Odogwu, Harry Randall, Dan Robson, Henry Slade, Anthony Watson, Ben Youngs.

Shadow squad: Charlie Atkinson, Ali Crossdale, Tom Dunn, Charlie Ewels, George Furbank, Joe Heyes, Jonathan Joseph, Joe Marchant, George Martin, Alex Mitchell, Jacob Umaga, Jack Willis.

Dan Lydiate has been recalled to the Wales squad for the Six Nations but there is no place for Rhys Webb.

Back-row Lydiate last played for his country against Australia in 2018, but the 33-year-old is among the 36 players selected by head coach Wayne Pivac.

Scrum-half Webb has been overlooked, with Gareth Davies, Tomos Williams and Kieran Hardy getting the nod.

Scarlets back-row Josh Macleod is the only uncapped player in the squad for a tournament Wales will start with an encounter against Ireland at the Principality Stadium on February 7.

Pivac revealed he was unable to pick Rhys Priestland, despite the fly-half being set to return to his homeland with Cardiff Blues next season, due to the 60-cap rule.

Captain Alun Wyn Jones is hopeful of being fit to face Ireland in Dublin as he continues his recovery from a knee injury.

Ross Moriarty, Gareth Anscombe, Rhys Patchell and Scott Williams are among the players ruled out due to injury.

Pivac said: "We are hugely looking forward to meeting up as a squad on Monday and to the forthcoming campaign. The Guinness Six Nations is an important tournament and we have selected a squad accordingly.

"As we consistently spoke about, the autumn for us was about opportunity and development, looking ahead to RWC 2023 and it served that purpose for us.

"This campaign is different, it is tournament rugby and we are excited to get going and to play our part. We have picked a squad for this tournament based on form and we are excited to meet up on Monday and to get our preparation underway."

Wales squad:

Forwards: Rhys Carre, Wyn Jones, Rhodri Jones, Elliot Dee, Ryan Elias, Ken Owens, Leon Brown, Tomas Francis, Dillon Lewis, Jake Ball, Adam Beard, Alun Wyn Jones (captain), Will Rowlands, Cory Hill, Dan Lydiate, Josh Navidi, Aaron Wainwright, Taulupe Faletau, Josh MacLeod, Justin Tipuric.

Backs: Gareth Davies, Tomos Williams, Kieran Hardy, Dan Biggar, Callum Sheedy, Jarrod Evans, Johnny Williams, Jonathan Davies, Nick Tompkins, Owen Watkin, George North, Josh Adams, Hallam Amos, Louis Rees-Zammit, Leigh Halfpenny, Liam Williams.

England head coach Eddie Jones is self-isolating after assistant Matt Proudfoot tested positive for coronavirus.

England Rugby announced on Wednesday that Proudfoot, who is asymptomatic, returned a positive in the latest round of pre-tournament testing ahead of the Six Nations and is now in isolation.

Jones and attack coach Simon Amor were identified as close contacts and must also self-isolate for 10 days, as per United Kingdom government guidelines.

Should they return further negative tests, Jones and Amor will be able to link up with the squad at St George's Park from January 28.

England, who are set to name their squad on Friday, are due to begin the defence of their Six Nations title against Scotland at Twickenham on February 6.

Jones is expected to name a 28-man selection featuring mostly established international players, with strict COVID-19 bubble arrangements meaning he cannot call up a larger group and allow those needing game time to return to their club sides.

Rassie Erasmus says South Africa will "explore any option" to ensure they do not miss out on facing the British and Irish Lions.

The Lions are scheduled to lock horns with the world champions in July and August, but the tour is in doubt due to the coronavirus pandemic.

Playing the series in the United Kingdom has been mooted as a potential alternative to the Lions flying out to South Africa.

Delaying the tour until next year could be another alternative and a decision is expected to be made next month, with talks among the Lions board ongoing.

South Africa's director of rugby Rassie Erasmus, who who coached the Springboks to Rugby World Cup glory in 2019, says the Webb Ellis Cup holders are willing to be flexible over where and when they take on the Lions.

"We desperately want to play the Lions, and we will do anything to play them," he said in a press conference.

"This series only comes around every 12 years. I have heard the different calls and opinions about the tour, and although we didn't play in the Rugby Championship because of player welfare, it was also because we knew there was this big series in 2021.

"If option one of playing in South Africa doesn't work out, we will go to option Z to make it happen.

"We don't want to lose out on the Lions series, we feel we deserve to play against them. I want to, Jacques Nienaber [Springboks head coach] wants to, the players want to. So from our side, we'll do anything.

"But yes, we will explore any option to play the Lions, we will play next year, we will play over there. This is the view from a player and management perspective."

Kyle Sinckler will miss England's opening game in this year's Six Nations after the prop was handed a two-week ban for swearing at a referee.

The Bristol Bears forward was cited by an independent commissioner for failing to respect the authority of a match official during Saturday's Premiership game against Exeter Chiefs.

Sinckler contested the charge at a disciplinary hearing, during which he accepted he had used foul language.

The 27-year-old was handed a suspension by an independent panel and will now be unavailable until February 9, three days after England open their 2021 campaign against Scotland.

"The player was candid in his evidence as to why he had done so and regretted his actions," a statement from the independent panel read.

"The panel found that his actions disrespected the authority of the referee and it was in breach of a core value of rugby - respect of match officials - and warranted a red card.

"The panel determined that in all the circumstances it was a low entry point with no relevant mitigation. The sanction is a two-week ban."

Following on from the Calcutta Cup clash at Twickenham, Eddie Jones' squad host Italy on February 13.

The Six Nations is scheduled to go ahead amid the ongoing coronavirus pandemic, though the European Champions Cup and Challenge Cup have been temporarily suspended after French authorities ruled the participation of Top 14 clubs to be too much of a public health risk.

The European Champions Cup and Challenge Cup have been temporarily suspended after the French authorities ruled the participation of Top 14 clubs to be too much of a public health risk. 

European Professional Club Rugby (EPCR) made the announcement on Monday following a meeting last week with French government officials. 

Due to concern over a new variant of coronavirus, the French government has decided to prevent its clubs from participating in games both in France and in the United Kingdom and Ireland. 

It means the EPCR has been forced to suspend the Champions Cup with two rounds of the pool phase remaining. The Challenge Cup is in its preliminary phase. 

The development would appear to place the 2021 Six Nations, scheduled to start with a meeting between France and Italy in Rome on February 6, in jeopardy. 

Last year's Six Nations tournament was only completed in October because of the pandemic-enforced delay. 

An EPCR statement read: "EPCR and the Ligue Nationale de Rugby took part in a meeting by audio conference last week with representatives of the French ministries of the Interior, Health and Sport, as well as of the President's office. 

"Notable updates to EPCR's COVID-19 protocols were presented to the French authorities, including the addition of PCR tests no earlier than three days before matches in the tournaments, conforming to French government guidelines and supplementing the existing, meticulous contact tracing measures put in place with a view to limiting the risk of transmission. 

"Against the backdrop of the recent detection of a new strain of coronavirus, the French government has directed that French clubs postpone their participation in EPCR's tournaments for the month of January, both for matches scheduled in France and for those due to be played in the United Kingdom and Ireland. 

"On the basis of this directive, EPCR had no choice but to temporarily suspend the pool stage of the Heineken Champions Cup and the preliminary stage of the Challenge Cup. 

"While respecting all further directives by governments and local authorities, and prioritising the health and welfare of players and club staff, EPCR, in conjunction with its shareholder leagues and unions, remains committed to trying to find a solution which will enable it to resume and complete the tournaments as soon as practicable. 

"EPCR will be making no further comment at the present time."