Three-time All-Star Khris Middleton will miss the rest of the Milwaukee Bucks' first-round series against the Chicago Bulls after spraining a ligament in his left knee.

Middleton, 30, averaged 20 points, five rebounds and five assists per game this season, but has been diagnosed with a sprained MCL after coming down awkwardly in the fourth quarter of Game 2 against the Bulls.

The scoring forward played a key role in the Bucks' championship last season, increasing his averages to 23 points, seven rebounds and five assists while playing over 40 minutes per contest during the 2020-21 postseason.

In the 16 games Middleton has missed this season, the Bucks are 7-9, going 3-5 on the road. 

Giannis Antetokounmpo has played in nine games this season without his All-Star teammate, and has scored 26.6 points per game at 49 per cent shooting – both down from his full-season averages of 29.9 points at 55 per cent.

However, in the one game this season between the Bucks and Bulls where Middleton was absent, Milwaukee dominated 126-98, as Jrue Holiday picked up the slack with 27 points and seven assists.

According to the Bucks, Middleton will be re-assessed in two weeks.

The series is locked at 1-1 after two games, and heads to Chicago for Game 3 and Game 4.