LeBron James will miss Wednesday's showcase game between his Los Angeles Lakers and the visiting Philadelphia 76ers.
The team is calling it knee soreness after he also missed a string of games in February with left-knee swelling.
James, 37, has played 54 out of a possible 72 games so far this season for the Lakers, and currently leads the league in points-per-game at 30.0, leading Joel Embiid (29.8) and Giannis Antetokounmpo (29.7).
If James were to hold off Embiid and Antetokounmpo, it would be just the second scoring title of his career after he also averaged 30.0 in the 2007-08 season with the Cleveland Cavaliers.
Embiid will need to score 45 points to finish the night in the lead for the scoring title.
In the four games the Lakers have won since the All-Star break, James is averaging 45 points, nine rebounds and seven assists.
The Lakers are ninth in the Western Conference with a 31-41 record going into the game.
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