The Phoenix Suns became the first team to secure a playoff spot with an impressive 111-90 defeat of the Miami Heat on Wednesday.
Devin Booker returned from a four-game absence to put up 23 points, nine assists and eight rebounds as the leaders of the West toppled the top side in the East.
The Suns, who are 53-13 for the season, have now beaten all other 29 teams in the same season for the first time since 2006-07.
"I told the guys it was one of the best defensive performances I've ever seen," said Suns coach Monty Williams after watching his team concede just 35 points in the second half. "I've been around for a little bit."
Duncan Robinson was top scorer for Miami with 22, who led by 11 in the early stages before falling to just their third defeat in 15 games.
"They were first to the ball a lot," said Robinson. "They were the aggressor. Unacceptable."
The Milwaukee Bucks are now two games behind the Heat at the top of the Eastern Conference after beating the Atlanta Hawks 124-115, with Giannis Antetokounmpo's double-double of 43 points and 12 rebounds firing them to a sixth-straight win.
Antetokounmpo finished 15-of-22 from the field to take his tally to 82 points in the space of 24 hours after his 39 in Tuesday's victory over the Oklahoma City Thunder.
"The things he does are not normal," said team-mate Bobby Portis. "It's fun to be his team-mate and fun to play alongside him."
Rockets stun Lakers in overtime
The Los Angeles Lakers lost for the ninth time in a row on the road, going down 139-130 in overtime against the Houston Rockets.
A triple-double from LeBron James and 30 points from Russell Westbrook were not enough as rookie Jalen Green hit a career-high 32 points for the Rockets.
"We have a really small margin of error this season and teams are making us pay," said James, whose run of consecutive 25-point games ended at 23. "I missed a lot of shots that I know I'm capable of making, have made throughout the course of the season and my career."
The Los Angeles Clippers snapped their two-game losing streak, beating the Washington Wizards 115-109, while the Utah Jazz improved to 41-24 with a comfortable 123-85 win over the Portland Trail Blazers.
Bulls back on track, Beasley sets record
The Chicago Bulls ended a run of five consecutive losses, DeMar DeRozan scoring 36 points, including 16 in the fourth quarter, in a 114-108 win over the Detroit Pistons.
It was a day to remember for Malik Beasley, who set a franchise record for three-pointers in the Minnesota Timberwolves' win at home over the Thunder.
Beasley landed 11 of his 17 attempts from beyond the arc as Minnesota, seventh in the West, made it six wins in a row.
The Boston Celtics continued their recent good form with a 115-101 win at the Charlotte Hornets, while the New York Knicks pulled off a fifth-straight road win over the Dallas Mavericks, Julius Randle scoring 26 points in a 107-77 blowout.
Gregg Popovich will have to wait for his NBA record 1,336th regular-season win as coach, the San Antonio Spurs falling 119-104 at home to the Toronto Raptors.
There were also wins for the Orlando Magic, who topped the New Orleans Pelicans 108-102, and the Denver Nuggets, who beat the Sacramento Kings 106-100 thanks to a 38-point double-double from Nikola Jokic.
Lakers will 'play 'til the wheels fall off', vows LeBron James
LeBron James has urged the Los Angeles Lakers to deal with the pressure, and thrive under it, as they aim to avoid a series sweep against the Denver Nuggets.
The Lakers slumped to a 3-0 lead in their first-round series against the reigning NBA champions following a 112-105 loss on Thursday.
Denver have now won 11 straight games against the Lakers, who squandered a big lead in Game 2 and were no match for the Nuggets in Game 3, with Nikola Jokic and Aaron Gordon in fine form.
James had 26 points and Anthony Davis had 33 for the Lakers, but Los Angeles went just 5 of 27 from the floor and missed 15 of their first 16 3-pointers.
Defeat means the Lakers will have to become the first team in NBA history to rally from a 0-3 playoff deficit to keep their postseason alive.
James, though, laid down the gauntlet for his teammates.
"It's one game at a time, at this point. You lose, you go home. You come out with the mindset, 'Let's get one, force a Game 5, and then we go from there,'" James said.
"As long as you still have life, then you obviously have belief. I just think you play 'til the wheels fall off. That's what it's always about for me.
"That's a mindset, and I know [Davis] feels the same way.
"You're supposed to have anxiety and pressure, or feel the pressure.
"That's what it's about. This is what the postseason is about.
"Me and this guy [Davis], have been playing together for six years. We've been to the mountaintop. We've been close to the mountaintop. We've played a lot of games.
"We know what it takes to win. We know what it takes to win a championship and how damn near perfect you got to be. That's not like something that's so crazy to obtain."
Lakers coach Darvin Ham came under criticism from some fans following the Game 3 loss, but he paid credit to the Nuggets.
"They have a championship confidence," he said.
"That starting group has been together for a long time. Their net rating is off the charts as a starting group. They had guys step up and make plays."
The Nuggets are taking nothing for granted.
"I think every game is tougher and tougher," Jokic said.
"They were up 20 in Denver; they were up 12 today in the first half. I think it's really hard to play against the same team over again.
"You can't get bored with the style of the play or whatever. You just need to keep doing you, especially for us - because we won the last three - and just trust what we are doing and don't get bored with success because it can go wrong really quick."
Embiid reveals Bell's palsy diagnosis after historic 50-point performance versus Knicks
Fresh from putting up 50 points in the Philadelphia 76ers' Game 3 win over the New York Knicks, Joel Embiid revealed he has been suffering from Bell's palsy, a condition affecting the left side of his face and causing blurred vision.
The reigning NBA MVP added eight rebounds and four assists to his half-century as the Sixers dragged themselves back into their first-round series after two road losses.
He became the first player in playoff history to record a 50-point game while attempting fewer than 20 shots, going 13 of 19 from the floor and making 19 of 21 free throws.
He did it while suffering from a condition which causes temporary weakness or lack of movement in one side of the face.
Embiid has to continually use eye drops to combat the blurred vision, and he says the symptoms could last for weeks or months.
"I think it started a day or two before the Miami game [in the Play-In tournament], and I had bad migraines and thought it was nothing," Embiid said in his post-game press conference.
"It's pretty annoying, you know, with the left side of my face, my mouth and my eye. So yeah, it's been tough.
"I'm not a quitter, so I've got to keep fighting, but yeah, it's unfortunate. That's the way I look at it. It's not an excuse. I've got to keep pushing."
Smiling, he added: "I just hope it could stay like this. I've got a beautiful face. I don't like it when my mouth is looking the other way.
"Like I said, it's an unfortunate situation, but everything happens for a reason. Like I said, I've got to take care of myself mentally."
Embiid has endured a difficult season after landing the NBA's top individual prize last year. He missed two months after undergoing surgery to repair the lateral meniscus in his left knee in February.
Still wearing a brace on the affected knee, Embiid said he is still unable to trust it completely.
"No, I'm just trying to keep pushing," he said when asked if he had 100 per cent confidence in his condition. "Like I said, I'm not going to quit.
"Even if it's on one leg, I'm still going to go out there and try, but no, that's not an excuse. I've got to keep playing better and better and better.
"Tonight I got lucky. I made a few shots. I've got to find a way to rebound, and I don't even care about rebounds. I've just got to make sure that my man doesn't get it, and then box out my man and take him out of the play. Whatever it takes to win."
NBA: Nuggets close to Lakers sweep, Embiid has 50 as Sixers cut deficit
The Denver Nuggets are on the brink of sweeping the Los Angeles Lakers after opening up a 3-0 lead in the teams' first-round series on Thursday, registering their 11th straight win against them.
Aaron Gordon had a playoff career-high 29 points and added 15 rebounds, while Nikola Jokic was just short of a triple-double with 24 points, 15 rebounds and nine assists as Denver clinched a 112-105 win.
Having squandered a big lead in Game 2, the Lakers failed to respond at home as the Nuggets began the second half with a 24-10 run to pull away from their hosts. Los Angeles failed to get closer than eight points in the fourth.
LeBron James had 26 points, six rebounds and nine assists, while Anthony Davis had 33 points and 15 rebounds, but Los Angeles were let down by their shooting from the field.
They shot just 5 of 27 from the floor, missing with 15 of their first 16 3-point attempts.
Game 4 takes place at Crypto.com Arena on Saturday, with the Lakers needing to become the first team in NBA history to rally from a 0-3 playoff deficit to keep James' 21st season alive.
A small group of home fans showed their displeasure with head coach Darvin Ham after the loss, staying behind to chant, "fire Darvin" as the rest of the crowd filtered out.
Embiid's half-century takes Knicks-Sixers to 2-1
Joel Embiid's huge 50-point haul breathed fresh life into the Philadelphia 76ers' series with the New York Knicks, bringing the Sixers back to 2-1 after two road losses to start the playoffs.
The 76ers triumphed 125-114 as Embiid became the first player in playoff history to score 50 points on fewer than 20 shots in a game, going 13 of 19 from the floor and making 19 of 21 free throws.
Philadelphia were three down at the half but produced a huge third quarter, Embiid dragging his team into a 98-85 lead with four 3s in that period.
Tyrese Maxey supported Embiid with 25 points and seven assists, after the NBA admitted the officials missed a foul on him in the closing stages of the Sixers' controversial Game 2 loss.
Jalen Brunson led the Knicks with 39 points and 13 assists while Josh Hart tacked on 20 points, but Donte DiVincenzo only had five after hitting the decisive 3-pointer in Game 2.
Cavs suffer worst playoff loss as Magic hit back
The Orlando Magic also hit back after losing the first two games of their first-round series, dealing the Cleveland Cavaliers the heaviest loss in their playoff history on Thursday.
Taking the series back to Kia Center after a pair of road losses, Orlando recorded a 121-83 win behind Paolo Banchero's 31 points, with Jalen Suggs adding 24 for the fifth seeds in the East.
Orlando led by as many as 43 points in the fourth quarter before ultimately settling for a 38-point margin. The Cavs' previous worst playoff loss was a 36-point defeat to the Washington Wizards in 2008.
Franz Wagner tacked on 16 points and eight assists for Orlando, who now have the chance to level the series at home in Game 4 on Sunday.
Cleveland had four players in double figures but none managed more than the 15 put up by both Jarrett Allen and Caris Levert, the visitors shooting a miserable 8 of 34 (23.5 per cent) from the floor.
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