Khris Middleton said he was "definitely concerned" and stand-in head coach Darvin Ham bemoaned another defeat as the Milwaukee Bucks tripped up once more against the Charlotte Hornets.

The Bucks have followed a run of six consecutive wins with four defeats in five games, the latest being a 103-99 setback to the Hornets at Spectrum Center.

Giannis Antetokounmpo scored 26 points with 13 rebounds and eight assists, while Middleton had 27 points, seven rebounds and 11 assists, yet the Bucks delivered an incomplete performance.

The Hornets improved to 22-19, while the sliding Bucks are now 26-17 for the season, following up their championship campaign in 2021 with something not quite so persuasive.

It was a second loss to the Hornets in three days for the Bucks, who, like so many other teams, are feeling the impact of the COVID-19 crisis.

Jrue Holiday has joined the ranks of Bucks stars sidelined and isolating due to the NBA's health and safety protocols, and inevitably his absence was felt. Holiday averages 18.4 per game this season and leads the team for assists (6.7)

Acting head coach Darvin Ham, leading the Bucks with Mike Budenholzer in health and safety protocols, could not coax out of the team a match-winning display, as James Borrego's Hornets extending their winning streak to three.

"My hat's off to Charlotte," Ham said. "JB has a great young group, it's a hell of an offensive team. And we just didn't make enough plays tonight.

"We just try to get to the game and as a staff, put our brains together and put together the best package possible. It's not going to be perfect, circumstances are what they are.

"I feel we're still in a position to win a game and we came up short."

From 99-99 with under half a minute remaining, LaMelo Ball sank the decisive shot and Miles Bridges made sure with two late free throws.

The Bucks looked to Middleton and Antetokounmpo in those late stages, which Ham said was the sensible play.

"Down the stretch you want the ball in the hands of your two best players and that was definitely deliberate," Ham said.

"Time and time again ... they've won a championship playing that way. There's not a better option in my opinion."

It gets no easier for the Bucks, who must tackle the Western Conference-leading Golden State Warriors on Thursday, albeit this time with home advantage.

Middleton, who had a fourth consecutive 20-plus point game, wants to see this slide halted as soon as possible.

He said: "I think you're definitely concerned – you never want to lose four out of five, you never want to lose two in a row."

Quoted in the Milwaukee Journal Sentinel, Middleton said: "We understand the circumstances. We're not using that as an excuse. Everybody's going through it.

"So we still have to find a way to… compete and give ourselves a chance to win, which we have these last two nights, we just couldn't pull it out."