LeBron James says the Los Angeles Lakers' slump is to be expected as they have "no chemistry" due to being so severely depleted.

The Lakers suffered a fourth straight defeat for the first time this season when they went down 138-110 to the San Antonio Spurs on Thursday.

Head coach Frank Vogel and five players were absent as a result of being under the NBA's health and safety protocols, while Anthony Davis remained sidelined with a knee injury in the final game at Staples Center before the venue becomes the Crypto.com Arena.

Four-time NBA champion and MVP James, who scored 36 points and claimed nine rebounds, says it should come as no surprise that the Lakers (16-17) are struggling.

He said: "Every year has its new challenges. This is another year where you can literally have one guy one night and the next night you don't. We've literally just seen that; having TA [Trevor Ariza] last game and then TA is out, so it's the unknown.

"Every time you take a test you've got to see who is positive and who is negative and go from there."

Lakers added: "In the past it's not like we had multiple guys who were out, we were just trying to figure out what's the best way for us to win and how do we win?

"What's the best line-ups to be on the floor? Let's log in so we can get better and better. We literally haven't had an opportunity to log-in anything.

"We don't know. We have no chemistry with any line-up from the single fact that we literally haven't logged enough minutes.

"What is our strong line-up besides me and Russ [Westbrook] and AD [Anthony Davis]? Or AD and Russ, or me and Russ? We've both been out, so we don't know."

Keita Bates-Diop scored a career-high 30 points for 13-18 San Antonio.