The Chicago Bulls will be without DeMar DeRozan against the Denver Nuggets on Monday after the star entered the NBA's health and safety protocols.

DeRozan is the third Bulls player to go through the league's COVID-19 protocols, joining team-mates Coby White and Javonte Green.

It remains to be seen how long four-time All-Star DeRozan will be sidelined in Chicago, where the new-look Bulls (16-8) have made a strong start to the season.

DeRozan has fuelled the Bulls, earning Eastern Conference Player of the Week honours having averaged 30.3 points and 5.7 rebounds while shooting 58.7 per cent from the field.

Entering Monday's play, DeRozan – who leads the league in points (633) – has been averaging 26.4 points per game, his best mark since the 2016-17 season.

DeRozan has also averaged 5.3 rebounds and 4.1 assists, while shooting 49.8 per cent from the field and 33.3 per cent from three-point range – the 32-year-old only managed better in 2015-16 (33.8).

Chicago defeated the Eastern Conference-leading Brooklyn Nets 111-107 on Saturday while outscoring their opponents 32-25 in the fourth quarter. The Bulls are averaging 28.3 points in the fourth quarter this season, the most in the NBA, according to Stats Perform.

Against the Nets, Zach LaVine poured in 31 points while DeRozan scored 29. This season, the Bulls are 9-2 when both players score at least 25 points and 7-6 when only one or neither hit that mark.