Brooklyn Nets superstar James Harden believes this is his best chance to win an NBA championship as the star-studded franchise continue their quest against the Milwaukee Bucks.

Harden, Kevin Durant and Kyrie Irving will lead the second-seeded Nets in an Eastern Conference semi-final showdown with Giannis Antetokounmpo and third seeds the Bucks, starting Saturday.

Brooklyn's 'big three' have the Nets as favourites to win their maiden championship in a playoff campaign also featuring the Philadelphia 76ers and Utah Jazz.

Harden joined the Nets from the Houston Rockets via a blockbuster trade in January, with the former MVP's eyes on a much-coveted title.

During his time in Houston, Harden reached two Western Conference Finals as the franchise never advanced to the showpiece – Stephen Curry and the Golden State Warriors often standing in the way, while LeBron James and the Los Angeles Lakers also thwarted the Rockets in the semi-finals last season.

Now, Harden senses his best opportunity to add an NBA ring to his list of league honours.

"I ran into some very, very good teams which is one of the reasons I've been short [of winning a title]," Harden told reporters via a Zoom call on Friday.

"[But] you look at our roster, we're elite too. It's going to be a showdown but I'm more than confident going into this postseason just because of the roster and our schemes and the things that we can control and the versatility that we have."

Harden added: "Obviously, there's only a handful of teams that have an opportunity. And we're one of those teams this year.

"So, the excitement is there, but I think just the focus is the most important thing for myself. And just trying to rub that focus level and that engagement to detail into every one of my team-mates."

The Nets saw off the Boston Celtics 4-1 in the opening round but will face a stiffer test against two-time reigning MVP Antetokounmpo and his Milwaukee support cast, including Jrue Holiday.

With Brooklyn's Jeff Green ruled out of Game 1, Nets head coach Steve Nash said: "I think the strategy we'll probably start with is probably similar from a team-defending standpoint.

"It's also the type of thing we have to work our way through as the series goes on and have a better feel for it, have more and more of an understanding collectively, and also be able to adjust and adapt within our schemes, not just change our schemes. The team concepts will be the same regardless."