The Phoenix Suns are hopeful but unsure about Chris Paul's availability for Game 6 after he injured his shoulder again in Tuesday's 115-85 win over the Los Angeles Lakers.

The Suns took a 3-2 series lead over the Lakers with a victory that was soured by Paul's injury, which leaves his availability for Game 6 on Thursday in doubt.

The 36-year-old went down in pain, clutching his right shoulder halfway through the third quarter after a minor collision with Laker Wesley Matthews.

Paul left the court and did not return to action, although he sat on the bench in the final minutes of the fourth quarter, with coach Monty Williams revealing he said he still had strength in the shoulder which has troubled him all series.

Williams preferred not to offer any official update, instead stating the Suns medical staff will assess Paul on Wednesday.

"He went in the back and got some treatment," Williams said. "When I talked with him when he came back out, he said he still had his strength.

"He seems to be okay but we want to wait until tomorrow after he wakes up and our medical team can make an assessment."

Paul, who played almost 23 minutes and scored nine points to go with six assists, said that the injury felt "very uncomfortable", leaving him "helpless".

"It scared me," Paul said during his post-match video conference. "It was just a very uncomfortable feeling. I felt helpless. When it happened, I was looking up and didn’t know what happened with Wes.

"But after I'd seen it I came back out on the court and I told Wes it was a clean play and it was unfortunate my neck and arm snapped again like it did."

The Lakers were missing their own star, with forward Anthony Davis absent due to a left groin strain.

Four-time NBA MVP LeBron James said he was preparing for Game 6 without Davis being available.

"My mindset is as if AD won't be in the game in Game 6, if something changes we go from there," James said post-match. "I'm preparing as if he's not."