Joel Embiid's injury last week appeared to clear a path for LeBron James to collect his fifth NBA MVP award.
Philadelphia 76ers big man Embiid - averaging 29.9 points and 11.5 rebounds, as well as 1.4 blocks and 1.2 steals - had already missed seven games this season before he went down with a knee injury against the Washington Wizards.
But Los Angeles Lakers superstar James did not see his clear run at the league's top individual honour last long.
James, who has 25.9 points, 7.9 assists and 7.9 rebounds per game, has carried the Lakers in Anthony Davis' absence but faces his own spell on the sidelines after an ankle sprain on Saturday.
That setback, in a defeat to the Atlanta Hawks, means this year's two leading MVP contenders face an uphill task to remain in contention as they sit out a key stretch of the regular season.
Nikola Jokic, the Denver Nuggets center, appears the man most likely to profit and has quickly been installed as the bookmakers' favourite.
But with several twists already in the race to succeed back-to-back winner Giannis Antetokounmpo, Jokic's standing is not yet safe.
With the help of Stats Perform data, we run through four potential winners ahead of Sunday's action - including Denver's 'Joker'.
NIKOLA JOKIC
The case against Jokic earlier in the season was his displays had not been able to lift the Nuggets into serious contention in the West. With 13 wins in their past 18 games to improve to 25-16, that is no longer the case.
While team-mate Jamal Murray has not been able to consistently perform at the standard he set in the 2019-20 playoffs - averaging 26.5 points in the 'bubble' but 21.1 this season - Jokic has taken his game to another level.
The Serbian's stat line for the year - 27.0 points, 8.6 assists, 11.2 rebounds and 1.6 steals - has never previously been achieved in league history, nor has any player in the past attempted at least 30 field goals across a season while shooting 56.6 per cent from the field, 41.6 per cent from three and 86.6 per cent of free throws.
This is an unprecedented campaign.
DAMIAN LILLARD
Tied with Denver at 25-16 in the West are the Portland Trail Blazers. Considering CJ McCollum has only played 16 games and Jusuf Nurkic 12, that is a quite remarkable achievement, led, of course, by Lillard.
Understandably, Lillard's usage rate is at a career-high 33 per cent, but he is making the most of those extra touches. Only Bradley Beal (32.5) has outperformed his 30.6 points per game - another career benchmark - and the Blazers star leads the league with 1,225 total points. Of those, 136 have come in 'clutch' situations, again putting Lillard at the top of the standings.
Taking a break from Portland's playoff push, Lillard even preserved enough energy to score 32 points in the All-Star Game, just ahead of Team LeBron team-mate and rival Stephen Curry (28). An MVP triumph would certainly see Portland's finest emerge from the shadow of the Golden State Warriors great.
GIANNIS ANTETOKOUNMPO
Antetokounmpo beat James Harden to this award in 2018-19 and then LA's James last season, so a case of voter fatigue was always set to make him an unlikely winner for a third straight year, regardless of performances.
But with Embiid and James both hit by injuries, the 'Greek Freak' surely has to come into consideration. Once again, his numbers are seriously impressive.
The only man to outscore Lillard at the All-Star Game, putting up 35, Antetokounmpo is slightly down on last year's points (29.0 versus 29.5) and rebounds per game (11.7 versus 13.6) but has improved in all of the other key metrics with 6.4 assists, 1.2 steals and 1.3 blocks.
The Milwaukee Bucks forward should be in the picture to retain both his MVP and Defensive Player of the Year titles.
JAMES HARDEN
Surely voters will not reward Harden in the year he forced his way out of the Houston Rockets? On performances alone, though, he deserves to be in the conversation.
The 2017-18 winner is not contributing the same number of points for the Brooklyn Nets as he was in Houston, but then his usage is down to 28.7 per cent for the year (28.1 in Brooklyn), by far the lowest it has been since the statistic was first tracked in 2014-15.
And Harden, still scoring an impressive 25.4 points since joining the Nets, is more than making up for this slight decline elsewhere.
So far the most prominent member of the team's 'big three', with Kevin Durant too often injured and Kyrie Irving absent for a spell, Harden leads the league in 2020-21 for assists (11.2) and is second for triple-doubles (11), making him an unpopular but worthy candidate.
Lakers will 'play 'til the wheels fall off', vows LeBron James
LeBron James has urged the Los Angeles Lakers to deal with the pressure, and thrive under it, as they aim to avoid a series sweep against the Denver Nuggets.
The Lakers slumped to a 3-0 lead in their first-round series against the reigning NBA champions following a 112-105 loss on Thursday.
Denver have now won 11 straight games against the Lakers, who squandered a big lead in Game 2 and were no match for the Nuggets in Game 3, with Nikola Jokic and Aaron Gordon in fine form.
James had 26 points and Anthony Davis had 33 for the Lakers, but Los Angeles went just 5 of 27 from the floor and missed 15 of their first 16 3-pointers.
Defeat means the Lakers will have to become the first team in NBA history to rally from a 0-3 playoff deficit to keep their postseason alive.
James, though, laid down the gauntlet for his teammates.
"It's one game at a time, at this point. You lose, you go home. You come out with the mindset, 'Let's get one, force a Game 5, and then we go from there,'" James said.
"As long as you still have life, then you obviously have belief. I just think you play 'til the wheels fall off. That's what it's always about for me.
"That's a mindset, and I know [Davis] feels the same way.
"You're supposed to have anxiety and pressure, or feel the pressure.
"That's what it's about. This is what the postseason is about.
"Me and this guy [Davis], have been playing together for six years. We've been to the mountaintop. We've been close to the mountaintop. We've played a lot of games.
"We know what it takes to win. We know what it takes to win a championship and how damn near perfect you got to be. That's not like something that's so crazy to obtain."
Lakers coach Darvin Ham came under criticism from some fans following the Game 3 loss, but he paid credit to the Nuggets.
"They have a championship confidence," he said.
"That starting group has been together for a long time. Their net rating is off the charts as a starting group. They had guys step up and make plays."
The Nuggets are taking nothing for granted.
"I think every game is tougher and tougher," Jokic said.
"They were up 20 in Denver; they were up 12 today in the first half. I think it's really hard to play against the same team over again.
"You can't get bored with the style of the play or whatever. You just need to keep doing you, especially for us - because we won the last three - and just trust what we are doing and don't get bored with success because it can go wrong really quick."
Embiid reveals Bell's palsy diagnosis after historic 50-point performance versus Knicks
Fresh from putting up 50 points in the Philadelphia 76ers' Game 3 win over the New York Knicks, Joel Embiid revealed he has been suffering from Bell's palsy, a condition affecting the left side of his face and causing blurred vision.
The reigning NBA MVP added eight rebounds and four assists to his half-century as the Sixers dragged themselves back into their first-round series after two road losses.
He became the first player in playoff history to record a 50-point game while attempting fewer than 20 shots, going 13 of 19 from the floor and making 19 of 21 free throws.
He did it while suffering from a condition which causes temporary weakness or lack of movement in one side of the face.
Embiid has to continually use eye drops to combat the blurred vision, and he says the symptoms could last for weeks or months.
"I think it started a day or two before the Miami game [in the Play-In tournament], and I had bad migraines and thought it was nothing," Embiid said in his post-game press conference.
"It's pretty annoying, you know, with the left side of my face, my mouth and my eye. So yeah, it's been tough.
"I'm not a quitter, so I've got to keep fighting, but yeah, it's unfortunate. That's the way I look at it. It's not an excuse. I've got to keep pushing."
Smiling, he added: "I just hope it could stay like this. I've got a beautiful face. I don't like it when my mouth is looking the other way.
"Like I said, it's an unfortunate situation, but everything happens for a reason. Like I said, I've got to take care of myself mentally."
Embiid has endured a difficult season after landing the NBA's top individual prize last year. He missed two months after undergoing surgery to repair the lateral meniscus in his left knee in February.
Still wearing a brace on the affected knee, Embiid said he is still unable to trust it completely.
"No, I'm just trying to keep pushing," he said when asked if he had 100 per cent confidence in his condition. "Like I said, I'm not going to quit.
"Even if it's on one leg, I'm still going to go out there and try, but no, that's not an excuse. I've got to keep playing better and better and better.
"Tonight I got lucky. I made a few shots. I've got to find a way to rebound, and I don't even care about rebounds. I've just got to make sure that my man doesn't get it, and then box out my man and take him out of the play. Whatever it takes to win."
NBA: Nuggets close to Lakers sweep, Embiid has 50 as Sixers cut deficit
The Denver Nuggets are on the brink of sweeping the Los Angeles Lakers after opening up a 3-0 lead in the teams' first-round series on Thursday, registering their 11th straight win against them.
Aaron Gordon had a playoff career-high 29 points and added 15 rebounds, while Nikola Jokic was just short of a triple-double with 24 points, 15 rebounds and nine assists as Denver clinched a 112-105 win.
Having squandered a big lead in Game 2, the Lakers failed to respond at home as the Nuggets began the second half with a 24-10 run to pull away from their hosts. Los Angeles failed to get closer than eight points in the fourth.
LeBron James had 26 points, six rebounds and nine assists, while Anthony Davis had 33 points and 15 rebounds, but Los Angeles were let down by their shooting from the field.
They shot just 5 of 27 from the floor, missing with 15 of their first 16 3-point attempts.
Game 4 takes place at Crypto.com Arena on Saturday, with the Lakers needing to become the first team in NBA history to rally from a 0-3 playoff deficit to keep James' 21st season alive.
A small group of home fans showed their displeasure with head coach Darvin Ham after the loss, staying behind to chant, "fire Darvin" as the rest of the crowd filtered out.
Embiid's half-century takes Knicks-Sixers to 2-1
Joel Embiid's huge 50-point haul breathed fresh life into the Philadelphia 76ers' series with the New York Knicks, bringing the Sixers back to 2-1 after two road losses to start the playoffs.
The 76ers triumphed 125-114 as Embiid became the first player in playoff history to score 50 points on fewer than 20 shots in a game, going 13 of 19 from the floor and making 19 of 21 free throws.
Philadelphia were three down at the half but produced a huge third quarter, Embiid dragging his team into a 98-85 lead with four 3s in that period.
Tyrese Maxey supported Embiid with 25 points and seven assists, after the NBA admitted the officials missed a foul on him in the closing stages of the Sixers' controversial Game 2 loss.
Jalen Brunson led the Knicks with 39 points and 13 assists while Josh Hart tacked on 20 points, but Donte DiVincenzo only had five after hitting the decisive 3-pointer in Game 2.
Cavs suffer worst playoff loss as Magic hit back
The Orlando Magic also hit back after losing the first two games of their first-round series, dealing the Cleveland Cavaliers the heaviest loss in their playoff history on Thursday.
Taking the series back to Kia Center after a pair of road losses, Orlando recorded a 121-83 win behind Paolo Banchero's 31 points, with Jalen Suggs adding 24 for the fifth seeds in the East.
Orlando led by as many as 43 points in the fourth quarter before ultimately settling for a 38-point margin. The Cavs' previous worst playoff loss was a 36-point defeat to the Washington Wizards in 2008.
Franz Wagner tacked on 16 points and eight assists for Orlando, who now have the chance to level the series at home in Game 4 on Sunday.
Cleveland had four players in double figures but none managed more than the 15 put up by both Jarrett Allen and Caris Levert, the visitors shooting a miserable 8 of 34 (23.5 per cent) from the floor.
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