Karl-Anthony Towns has pledged the Minnesota Timberwolves will not waste a golden opportunity in their Western Conference semifinal series against the Denver Nuggets, having seized a 2-0 lead.

Towns joined Anthony Edwards in putting up 27 points as the third-seeded Timberwolves claimed a comfortable 106-80 win on Monday, two days on from a 106-99 Game 1 victory.

Nikola Jokic was held to just 16 points on 5-of-13 shooting as Minnesota produced another outstanding defensive performance, while Jamal Murray only managed eight points in 36 minutes.

Minnesota return home for the first of back-to-back games at Target Center on Friday, knowing they have the chance to finish the series off on their own turf.

It is not an opportunity Towns intends to see pass them by.

"We're extremely honoured and blessed that we have this opportunity to go home up 2-0," Towns said. 

"But we're humble in this approach. We understand that we've put ourselves in a great position, but as great as the position we are in is, it could be very bad if we don't win our homestand.

"So, we've just got to go out there, take care of business, do what we do, play defense at a high level, and execute even at a higher level because the defending champions, you can't give them a minute of slippage at all in the game."

Minnesota should be further boosted by Friday with Rudy Gobert set to return after missing Monday's game to attend the birth of his first child.

Given the Timberwolves were without the Defensive Player of the Year favourite, coach Chris Finch believes shutting down the reigning NBA champions ranked among their best defensive efforts this season.

"We've had some really, really good defensive efforts this year but that has to be right up there with the best of them," Finch said. 

"On the ball, off the ball, the physicality, the execution of the gameplan… we just really locked in on defense."