Kawhi Leonard claimed there is a "different dynamic" to the Los Angeles Lakers when LeBron James is out.

Leonard recorded a triple-double of 25 points, 11 rebounds and 10 assists, while James Harden had 23 points and 10 assists, as the Los Angeles Clippers defeated a Lakers team shorn of superstar James 127-116 on Tuesday.

James was out with an ankle issue, with the Lakers treating his recovery on a day-to-day basis.

While the Clippers have won 11 of their last 13 games, the Lakers have now lost four road wins on the spin.

Leonard suggested there was a noticeable difference to the Lakers, not that players did not step up in James' absence. D'Angelo Russell led the Lakers with 27 points and Anthony Davis had 26.

"It's a different dynamic with him not being out there," Leonard said.

"You saw guys came in and stepped up and made big shots for him."

Reflecting on the Clippers' display, Leonard added: "Everybody contributed to the win. That's what we've got to do, knock down shots when they're open and tonight we did."

Despite a win that has taken the Clippers, who are fourth in the Western Conference, to a 28-14 winning record, coach Tyronn Lue said there is still plenty to improve on.

"Just overall, [we] didn't play a good mental game and we didn't do a good job with our coverages, especially defensively," Lue said.

"We were all over the place. We've just got to continue to keep getting better."

Leonard added: "They're a good transition team and we allowed them to play to their strengths. We just got to be better at that."

Lakers boss Darvin Ham, meanwhile, took positives from the defeat.

He said: "Like I told them just now, a lot of good things we did during this game.

"Our guys competed, competed their butts off. The [Clippers are] going to make you pay [for mistakes], that's how they're built.

"They are in a really good rhythm. But that said, I think the lesson tonight is how we competed, how we competed together. Again, guys taking accountability for mistakes and not making them twice.

"Trying to get better defensively as the game was ticking away. Disappointed in the loss but proud of how our guys competed minus LeBron."

On LeBron's status, Ham added: "Just trying to be proactive with his ankle. He'll probably be day-to-day. But that's pretty much it."